Books (during time at WUSTL)
Walsh, C. T.; Wencewicz, T. A. “Antibiotics: Challenges, Mechanisms, Opportunities.” January 2016, ASM Press, Washington DC, USA. ISBN 9781555819309
Book Chapters (during time at WUSTL)
Wencewicz, T. A.*; Miller, M. J. “Sideromycins as Pathogen-Targeted Antibiotics.” in Topics in Medicinal Chemistry. 2017, Springer, Berlin, Heidelberg. DOI: 10.1007/7355_2017_19
Review Articles (during time at WUSTL)
Wencewicz, T. A.* “Crossroads of Antibiotic Resistance and Biosynthesis.” Journal of Molecular Biology, 2019, 431, 3370-3399. Invited article for special issue on “The Molecular Basis of Antibiotic Action and Resistance.”
Markley, J. L.; Wencewicz, T. A.* “Tetracycline-Inactivating Enzymes” Front. Microbiol. 2018, 9, article 1058. Invited article for special issue on “Bacterial Mechanisms of Antibiotic Resistance: a Structural Perspective”.
Wencewicz, T. A.* “New Antibiotics from Nature’s Chemical Inventory.” Bioorganic & Medicinal Chemistry 2016, 24, 6227–6252. Invited article for special issue on the “Discovery of Novel Antibacterials.”
Original Research Articles (during time at WUSTL)
Blake, K.S.; Kumar, H.; Loganathan, A.; Williford, E.E.; Diorio-Toth, L.; Xue, Y; Tang, W.; Campbell, T.P.; Chong, D.D.; Angtuaco, S.; Wencewicz, T.A.*; Tolia, N.H.*; Dantas, G.* Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes.” Communications Biology 2024, 7, 336. *Indicates co-corresponding authors.
Dorsainvil, J.M. ; Palmquist, M.S.; Yang, J.; Delawder, A.O.; Danielson, M.K.; Zhang, Y.; Saak, T.M.; Gruschka, M.C.; Kong, X.; Wencewicz, T. A.; Barnes, J.C.* Electrostatic loading and photoredox-accelerated release of antibiotics from oligoviologen-crosslinked hydrogels using red light.” Mater. Today Chem. 2024, 35, 101847.
Yang, J.; Banas, V.S.; Rivera, G.S.M.; Wencewicz, T.A.* “Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis.” ACS Chemical Biology 2023,18, 6, 1266–1270.
Kumar, H.; Williford, E.E; Blake, K.S.; Virgin-Downey, B.; Dantas, G.*; Wencewicz, T.A.*; Tolia, N.H.* “Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type I tetracycline destructases.” Communications Biology 2023, 6, 423. *Indicates co-corresponding authors.
Williford, E.E.; DeAngelo, C. M.; Blake, K. S.; Kumar, H.; Lam, K.K.; Jones, K.V.; Tolia, N.H.*; Dantas, G.*; Wencewicz, T.A.* “Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling.” ACS Journal of Medicinal Chemistry 2023, 66, 6, 3917–3933. *Indicates co-corresponding authors.
Yang, J.; Wencewicz, T.A.* “In vitro reconstitution of fimsbaction biosynthesis from Acinetobacter baumannii.” ACS Chemical Biology 2022, 17, 10, 2923–2935.
Yang, J.;Banas, V. S.; Patel, K. D.; Rivera, G. S. M.; Mydy, L. S.; Wencewicz, T. A.*; Gulick, A. M.* “An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD.” Journal of Biological Chemistry 2022, 298, 8, 102166. *Indicates co-corresponding authors.
Yang, J.; Qi, Y.; Blodgett, J. A.*; & Wencewicz, T. A.* “Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C–H Bond Activations.” Journal of Natural Products 2022, 85, 1, 47–55. *Indicates co-corresponding authors.
Valentino, H.; Korasick, D. A.; Bohac, T. J.; Shapiro, J. A.; Wencewicz, T. A.*; Tanner, J. J.*; Sobrado, P. “Structural and biochemical characterization of the flavin-dependent siderophore-interacting protein from Acinetobacter baumannii.” ACS omega 2021, 6, 18537-18547. *Indicates co-corresponding authors.
Bohac, T. J.; Fang, L.; Banas V. S.; Giblin, D. E.; Wencewicz, T. A.* “Synthetic Mimics of Native Siderophores Disrupt Iron Trafficking in Acinetobacter baumannii.” ACS Infectious Diseases 2021, 7, 2138-2151.
Gasparrini, A.J.; Markley, J.L.; Kumar, H.; Wang, B.; Fang, L.; Irum, S.; Symister C.T.; Wallace, M.; Burnham, C.D.; Andleeb, S., Tolia, N. H.*, Wencewicz, T.A.*; Dantas, G.* “Tetracycline-Inactivating Enzymes from Environmental, Human Commensal, and Pathogenic Bacteria Cause Broad-Spectrum Tetracycline Resistance.” Communications Biology 2020, 3, 1-12. *Indicates co-corresponding authors.
Endicott, N.P.; Rivera, G.S.M.; Yang, J.; Wencewicz, T.A.* “Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria.” ACS Central Science 2020, 6, 493-506.
Kreitler, D. F.; Gemmell, E. M.; Schaffer, J. E.; Wencewicz, T. A.*; Gulick, A. M.* “The Structural Basis of N-Acyl-alpha-amino-beta-lactone Formation Catalyzed by a Nonribosomal Peptide Synthetase.” Nature Communications 2019, 10, 3432. *Indicates co-corresponding authors. See the media coverage.
Markley, J. L.; Fang, L.; Gasparrini, A. J.; Symister, C. T.; Kumar, H.; Tolia, N. H.*; Dantas, G.*; Wencewicz, T. A.* “Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes.” ACS Infectious Diseases 2019, 5, 618-633. *Indicates co-corresponding authors.
Bohac, T. J.; Fang, L.; Giblin, D. E.; Wencewicz, T. A. “Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii.” ACS Chemical Biology 2019, 14, 674-687.
Bailey, D. C.; Bohac, T. J.; Shapiro, J. A.; Giblin, D. E.; Wencewicz, T. A.*; Gulick, A. M.* “Crystal Stucture of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron.” Biochemistry 2018, 57, 6653-6661. *Indicates co-corresponding authors.
Markley, J. L.; Morse, T. L.; Rath, N. P.; Wencewicz, T. A.* “Stream-lined Synthesis of 3-Hydroxy-Beta-Lactams: Norrish-Yang Type II Photocyclizations of Beta-Ketoformamides.” Tetrahedron 2018, 74, 2743-2753.
Rivera, G. S. M.; Beamish, C. R.; Wencewicz, T. A.* “Immobilized FhuD2 Siderophore-Binding Protein Enables Purification of Salmycin Sideromycins from Streptomyces violaceus DSM 8286.” ACS Infectious Diseases 2018, 4, 845-859.
Patrick, G. J.; Fang, L.; Schaefer, J.; Singh, S.; Bowman, G. R.; Wencewicz, T. A.* “Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-beta-lactam.” Biochemistry 2018, 57, 117-135. Featured in special issue on the “Future of Biochemistry”.
Bohac, T. J.; Shapiro, J. A.; Wencewicz, T. A.* “Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii.” ACS Infectious Diseases 2017, 3, 802-806. (Bohac and Shapiro are co-first authors)
Schaffer, J. E.; Reck, M. R.; Prasad, N. K.; Wencewicz, T. A.* “Beta-Lactone Formation During Antibiotic Cleavage from a Nonribosomal Peptide Synthetase.” Nature Chemical Biology 2017, 13, 737–744. F1000 feature article. (Schaffer and Reck are co-first authors)
Park, J.; Gasparrini, A. J.; Reck, M. R.; Symister, C.; Elliott, J. L.; Vogel, J. P.; Wencewicz, T. A.*; Dantas, G.*; Tolia, N. H.* “Plasticity, Dynamics, and Inhibition of Emerging Tetracycline-Resistance Enzymes.” Nature Chemical Biology 2017, 13, 730–736. *Indicates co-corresponding authors.
Endicott, N. P.; Lee, E.; Wencewicz, T. A.* “Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus.” ACS Infectious Diseases 2017, 3, 542–553.
Shapiro, J. A. and Wencewicz, T. A. “Structure-Function Studies of Acinetobactin Analogs.” Metallomics 2017, 9, 463–470. Featured on inside journal cover. Editor’s choice as “HOT ARTICLE.”
Shapiro, J. A. and Wencewicz, T. A.* “Acinetobactin Isomerization Enables Adaptive Iron Acquisition in Acinetobacter baumannii through pH-Triggered Siderophore Swapping.” ACS Infect. Dis. 2016, 2, 157–168. Featured on journal cover.
Hart, K. M., Reck, M. R., Bowman, G. R., Wencewicz, T. A.* “Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance.” Med. Chem. Commun. 2016, 7, 118–127. Invited article for special issue on antibiotics.
Gelman, S. J.; Mahieu, N. G.; Cho, K.; Llufrio, E. M.; Wencewicz, T. A.; Patti, G. J.* “Evidence that 2-Hydroxyglutarate is Not Readily Metabolized in Colorectal Carcinoma Cells.” Cancer Metabolism 2015, 3:13.
Forsberg, K. J.; Patel, S.; Wencewicz, T. A.*; Dantas, G.* “The tetracycline destructases: a novel family of tetracycline-inactivating enzymes.” Chemistry and Biology 2015, 22, 888–897. *Indicates co-corresponding authors.
Review Articles (Postdoc)
Walsh, C. T.*; Wencewicz, T. A. “Prospects for new antibiotics: A molecule-centered perspective.” J. Antibiotics 2014, 67, 7–22. Winner of JA Medal for excellence!
Walsh, C. T.*; Wencewicz, T. A. “Flavoenzymes: Versatile catalysts in biosynthetic pathways.” Nat. Prod. Rep. 2012, 30,175–200.
Original Research Articles (Postdoc)
Wencewicz, T. A.; Walsh, C. T.* “P. syringae self protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr.” Biochemistry 2012, 51, 7712–7725.
Review Articles (PhD)
Wencewicz, T. A.; Möllmann, U.; Long, T. E.; Miller, M. J.* “Is drugrelease necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurringsalmycin ‘Trojan Horse’ antibiotics and synthetic desferridanoxamine-antibiotic conjugates.” Biometals 2009, 22, 633–648.
Original Research Articles (PhD)
Wencewicz, T. A.; Miller, M. J.* “Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii.” J. Med. Chem. 2013, 56, 4044–4052.
Original Research Articles (undergraduate)
Ali, M. H.*; Hedell, J.; Wencewicz, T. “Oxidation of sulfides to sulfoxides with 1,3-dibromo-5,5-dimethylhydantoin in the presence of hydrated silica gel.” Journal of Sulfur Chemistry 2009, 30, 160–166.