Books (during time at WUSTL)

Walsh, C. T.; Wencewicz, T. A. “Antibiotics: Challenges, Mechanisms, Opportunities.” January 2016, ASM Press, Washington DC, USA. ISBN 9781555819309

Book Chapters (during time at WUSTL)

Wencewicz, T. A.*; Miller, M. J. “Sideromycins as Pathogen-Targeted Antibiotics.” in Topics in Medicinal Chemistry2017, Springer, Berlin, Heidelberg. DOI: 10.1007/7355_2017_19

Original Research Articles (during time at WUSTL)

Kumar, H.; Williford, E.E; Blake, K.S.; Virgin-Downey, B.; Dantas, G.*; Wencewicz, T.A.;* Tolia, N.H.* “Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type I tetracycline destructases.” Communications Biology 2023, 6, 423. *Indicates co-corresponding authors. 

Williford, E.E.; DeAngelo, C. M.; Blake, K. S.; Kumar, H.; Lam, K.K.; Jones, K.V.; Tolia, N.H.*; Dantas, G.*; Wencewicz, T.A.* “Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling.” ACS Journal of Medicinal Chemistry 2023, 66, 6, 3917–3933. *Indicates co-corresponding authors.

Yang, J.; Wencewicz, T.A.* “In vitro reconstitution of fimsbaction biosynthesis from Acinetobacter baumannii.ACS Chemical Biology 2022, 17, 10, 2923–2935.

Yang, J.;Banas, V. S.; Patel, K. D.; Rivera, G. S. M.; Mydy, L. S.; Wencewicz, T. A.*; Gulick, A. M.* “An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD.Journal of Biological Chemistry 2022, 298, 8, 102166. *Indicates co-coresponding authors.

Yang, J.; Qi, Y.; Blodgett, J. A.*; & Wencewicz, T. A.* “Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C–H Bond Activations.” Journal of Natural Products 2022, 85, 1, 47–55. *Indicates co-corresponding authors.

Valentino, H.; Korasick, D. A.; Bohac, T. J.; Shapiro, J. A.; Wencewicz, T. A.*; Tanner, J. J.*; Sobrado, P. “Structural and biochemical characterization of the flavin-dependent siderophore-interacting protein from Acinetobacter baumannii.” ACS omega 2021, 6, 18537-18547. *Indicates co-corresponding authors.

Bohac, T. J.; Fang, L.; Banas V. S.; Giblin, D. E.; Wencewicz, T. A.* “Synthetic Mimics of Native Siderophores Disrupt Iron Trafficking in Acinetobacter baumannii.” ACS Infectious Diseases 2021, 7, 2138-2151.

Gasparrini, A.J.; Markley, J.L.; Kumar, H.; Wang, B.; Fang, L.; Irum, S.; Symister C.T.; Wallace, M.; Burnham, C.D.; Andleeb, S., Tolia, N. H.*, Wencewicz, T.A.*; Dantas, G.* “Tetracycline-Inactivating Enzymes from Environmental, Human Commensal, and Pathogenic Bacteria Cause Broad-Spectrum Tetracycline Resistance.Communications Biology 20203, 1-12. *Indicates co-corresponding authors.

Endicott, N.P.; Rivera, G.S.M.; Yang, J.; Wencewicz, T.A.* “Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria.ACS Central Science 20206, 493-506.

Kreitler, D. F.; Gemmell, E. M.; Schaffer, J. E.; Wencewicz, T. A.*; Gulick, A. M.* “The Structural Basis of N-Acyl-alpha-amino-beta-lactone Formation Catalyzed by a Nonribosomal Peptide Synthetase.” Nature Communications 201910, 3432. *Indicates co-corresponding authors. See the media coverage.

Markley, J. L.; Fang, L.; Gasparrini, A. J.; Symister, C. T.; Kumar, H.; Tolia, N. H.*; Dantas, G.*; Wencewicz, T. A.* “Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes.” ACS Infectious Diseases 20195, 618-633. *Indicates co-corresponding authors.

Bohac, T. J.; Fang, L.; Giblin, D. E.; Wencewicz, T. A. “Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii.” ACS Chemical Biology 201914, 674-687.

Bailey, D. C.; Bohac, T. J.; Shapiro, J. A.; Giblin, D. E.; Wencewicz, T. A.*; Gulick, A. M.* “Crystal Stucture of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron.” Biochemistry 201857, 6653-6661. *Indicates co-corresponding authors.

Markley, J. L.; Morse, T. L.; Rath, N. P.; Wencewicz, T. A.* “Stream-lined Synthesis of 3-Hydroxy-Beta-Lactams: Norrish-Yang Type II Photocyclizations of Beta-Ketoformamides.” Tetrahedron 201874, 2743-2753.

Rivera, G. S. M.; Beamish, C. R.; Wencewicz, T. A.* “Immobilized FhuD2 Siderophore-Binding Protein Enables Purification of Salmycin Sideromycins from Streptomyces violaceus DSM 8286.” ACS Infectious Diseases 20184, 845-859.

Patrick, G. J.; Fang, L.; Schaefer, J.; Singh, S.; Bowman, G. R.; Wencewicz, T. A.* “Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-beta-lactam.” Biochemistry 201857, 117-135. Featured in special issue on the “Future of Biochemistry”.

Bohac, T. J.; Shapiro, J. A.; Wencewicz, T. A.* “Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii.” ACS Infectious Diseases 20173, 802-806. (Bohac and Shapiro are co-first authors)

Schaffer, J. E.; Reck, M. R.; Prasad, N. K.; Wencewicz, T. A.* “Beta-Lactone Formation During Antibiotic Cleavage from a Nonribosomal Peptide Synthetase.” Nature Chemical Biology 201713, 737–744. F1000 feature article. (Schaffer and Reck are co-first authors)

Park, J.; Gasparrini, A. J.; Reck, M. R.; Symister, C.; Elliott, J. L.; Vogel, J. P.; Wencewicz, T. A.*; Dantas, G.*; Tolia, N. H.* “Plasticity, Dynamics, and Inhibition of Emerging Tetracycline-Resistance Enzymes.” Nature Chemical Biology 201713, 730–736. *Indicates co-corresponding authors.

Endicott, N. P.; Lee, E.; Wencewicz, T. A.* “Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus.” ACS Infectious Diseases 20173, 542–553.

Shapiro, J. A. and Wencewicz, T. A. “Structure-Function Studies of Acinetobactin Analogs.” Metallomics 20179, 463–470. Featured on inside journal cover. Editor’s choice as “HOT ARTICLE.”

Shapiro, J. A. and Wencewicz, T. A.* “Acinetobactin Isomerization Enables Adaptive Iron Acquisition in Acinetobacter baumannii through pH-Triggered Siderophore Swapping.” ACS Infect. Dis20162, 157–168. Featured on journal cover.

Hart, K. M., Reck, M. R., Bowman, G. R., Wencewicz, T. A.* “Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance.” Med. Chem. Commun. 20167, 118–127. Invited article for special issue on antibiotics.

Gelman, S. J.; Mahieu, N. G.; Cho, K.; Llufrio, E. M.; Wencewicz, T. A.; Patti, G. J.* “Evidence that 2-Hydroxyglutarate is Not Readily Metabolized in Colorectal Carcinoma Cells.” Cancer Metabolism 2015, 3:13.

Forsberg, K. J.; Patel, S.; Wencewicz, T. A.*; Dantas, G.* “The tetracycline destructases: a novel family of tetracycline-inactivating enzymes.” Chemistry and Biology 201522, 888–897. *Indicates co-corresponding authors.

Review Articles (Postdoc)

Walsh, C. T.*; Wencewicz, T. A. “Prospects for new antibiotics: A molecule-centered perspective.” J. Antibiotics 201467, 722. Winner of JA Medal for excellence!

Walsh, C. T.*; Wencewicz, T. A. “Flavoenzymes: Versatile catalysts in biosynthetic pathways.” Nat. Prod. Rep. 201230,175200.

Original Research Articles (Postdoc)

Wencewicz, T. A.; Walsh, C. T.* “P. syringae self protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr.” Biochemistry 201251, 77127725.

Original Research Articles (PhD)

Wencewicz, T. A.; Miller, M. J.* “Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii.” J. Med. Chem. 201356, 40444052.

Wencewicz, T. A.; Long, T. E.; Möllmann, U.; Miller, M. J.* “Trihydroxamate siderophore-fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus.” Bioconjugate Chemistry 201324, 473486.
Wencewicz, T. A.; Oliver, A. G.; Miller, M. J.* “Iron(III)-templated macrolactonization of trihydroxamate siderophores.” Org. Lett. 201214, 43904393.
Mayfield, J. A.; Frederick, R. E.; Streit, B. R.; Wencewicz, T. A.; Ballou, D. P.; DuBois, J. L.* “Comprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenase.” J. Biol. Chem. 2010285, 3037530388.
Yan, S.; Miller, M. J.*; Wencewicz, T. A.; Möllmann, U. “Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.” Med. Chem. Commun20101, 145148.
Yan, S.; Miller, M. J.*; Wencewicz, T. A.; Möllmann, U. “Syntheses and antibacterial activity studies of new
oxazolidinones from nitroso Diels-Alder chemistry.” Bioorg. & Med. Chem. Lett. 201020, 13021305.

Original Research Articles (undergraduate)

Ali, M. H.*; Hedell, J.; Wencewicz, T. “Oxidation of sulfides to sulfoxides with 1,3-dibromo-5,5-dimethylhydantoin in the presence of hydrated silica gel.” Journal of Sulfur Chemistry 200930, 160166.

Ali, M. H.*; Kriedelbaugh, D.; Wencewicz, T. “Ceric ammonium nitrate (CAN) catalyzed oxidation of sulfides to sulfoxides.” Synthesis 2007, 22, 35073511.
Ali, M. H.*; Hartman, M.; Lamp, K.; Schmitz, C.; Wencewicz, T. “Oxidation of sulfides with N-bromosuccinimide in the presence of hydrated silica gel.” Synthetic Communications 2006, 36, 17691777.