*Bold indicates trainees enrolled in the ITVS Pathway.
Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration. Wang Z, Zhao C, Xu S, McCracken S, Apte RS, Williams PR. Res Sq. Mar 2025. |html| |pdf|
Molecular mechanism establishing the OFF pathway in vision. Soto F, Lin CI, Jo A, Chou S-Y, Harding E, Ruzycki PA, Seabold GK, Petralia RS, Kerschensteiner D. Nat Commun. Apr 2025. |html| |pdf|
Mistargeted retinal axons induce a synaptically independent subcircuit in the visual thalamus of albino mice. McCracken S, McCoy L, Hu Z, Hodges JA, Valkova K, Williams PR, Morgan JL. eLife. Mar 2025. |html| |pdf|
Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development. Hernández-Núñez I, Urman A, Zhang X, Jacobs W, Hoffmann C, Rebba S, Harding EG, Li Q, Mao F, Cani AK, Chen S, Dawlaty MM, Rao RC, Ruzycki PA, Edwards JR, Clark BS. bioRxiv. Feb 2025. |html| |pdf|
Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Volkov LI, Ogawa Y, Somjee R, Vedder HE, Powell HE, Poria D, Meiselman S, Kefalov VJ, Corbo J. PNAS. Nov 2024. |html| |pdf|
Temperature-dependent predation predicts a more reptilian future. Grady JM, Amme JL, Bhaskaran-Nair K, Sinha V, Brunwasser SJ, Record S, Dell AI, Hengen KB. bioRxiv. Sep 2024. |html| |pdf|
Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration. Terao R, Sohn BS, Yamamoto T, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Yamaguchi S, Yoshida M, Apte RS. Invest Ophthalmol Vis Sci. Aug 2024. |html| | pdf| |Research Insight|
Retinal lineages: One cell at a time. Craigen E, Enright J, Clark BS. Ref Module in Neurosci and Biobehavioral Psych. May 2024.
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion. Terao R, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Hase K, Yamaguchi S, Du D, Sohn BS, Sasaki Y, Yoshida M, Apte RS. Cell Rep. May 2024. |html| |pdf|
Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retina. Friedrichsen K, Hsiang JC, Lin CI, McCoy L, Valkova K, Kerschensteiner D, Morgan JL. Nat Commun. Apr 2024. |html| |pdf|
Predation without direction selectivity. Krizan J, Song X, Fitzpatrick MJ, Shen N, Soto F, Kerschensteiner D. PNAS. Mar 2024. |html| |pdf|
Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Pfeifer CW, Walsh JT, Santeford A, Lin JB, Beatty WL, Terao R, Liu YA, Hase K, Ruzycki PA, Apte RS. PNAS. Nov 2023. |html| |pdf|
Diversity in homeostatic calcium set points predicts retinal ganglion cell survival following optic nerve injury in vivo. McCracken S, Fitzpatrick MJ, Hall AL, Wang Z, Kerschensteiner D, Morgan JL, Williams PR. Cell Rep. Oct 2023. |html| |pdf|
Dissecting cell identity via network inference and in silico gene perturbation. Kamimoto K, Stringa B, Hoffmann CM, Jindal K, Solnica-Krezel L, Morris SA. Nature. Feb 2023. |html| |pdf|
Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis. Lin JB, Shen X, Pfeifer CW, Shiau F, Santeford A, Ruzycki P, Clark BS, Liu Q, Huang AJW, Apte RS. PNAS. Jan 2023. | html | pdf |
Gene regulatory network reconfiguration in direct lineage reprogramming. Kamimoto K, Adil MT, Jindal K, Hoffmann CM, Kong W, Yang X, Morris SA. Stem Cell Reports. Jan 2023. |html| |pdf|
Cell-type-specific binocular vision guides predation in mice. Johnson KP, Fitzpatrick MJ, Zhao L, Wang B, McCracken S, Williams PR, Kerschensteiner D. Neuron. May 2021. | html | pdf |
Transpupillary two-photon in vivo imaging of the mouse retina. Wang Z, McCracken S, Williams PR. J Vis Exp. Feb 2021. | html | pdf |