Loss of Brain Aerobic Glycolysis in Normal Human Aging
We found that brain metabolism, particularly aerobic glycolysis, changes significantly with age in a large cross-sectional cohort of cognitively normal, brain amyloid negative volunteers.
Our preliminary data shows that tau deposition in the brain, a critical feature of Alzheimer disease among other neurodegenerative conditions, is associated with decreased aerobic glycolysis.
Great work led by Tyler Blazey and others in confirming the regional differences in aerobic glycolysis in normal young adults.
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