Loss of Brain Aerobic Glycolysis in Normal Human Aging

We found that brain metabolism, particularly aerobic glycolysis, changes significantly with age in a large cross-sectional cohort of cognitively normal, brain amyloid negative volunteers.

Goyal, M.S., Vlassenko, A.G., Blazey, T.M., Su, Y., Couture, L.E., Durbin, T.J., Bateman, R.J., Benzinger, T.L.S., Morris, J.C. and Raichle, M.E., 2017. Cell metabolism26(2), pp.353-360.

Aerobic glycolysis and tau deposition in preclinical Alzheimer disease

Our preliminary data shows that tau deposition in the brain, a critical feature of Alzheimer disease among other neurodegenerative conditions, is associated with decreased aerobic glycolysis.

Vlassenko, A.G., Gordon, B.A., Goyal, M.S., Su, Y., Blazey, T.M., Durbin, T.J., Couture, L.E., Christensen, J.J., Jafri, H., Morris, J.C. and Raichle, M.E., 2018. Neurobiology of Aging.

Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain.

Great work led by Tyler Blazey and others in confirming the regional differences in aerobic glycolysis in normal young adults.

Blazey, T., Snyder, A.Z., Su, Y., Goyal, M.S., Lee, J.J., Vlassenko, A.G., Arbeláez, A.M. and Raichle, M.E., 2018. Journal of Cerebral Blood Flow & Metabolism, p.0271678X18767005.

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