Genomic andneoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma., Schutt CR, Sun H, Pradham JS, Saenger Y, Ley J, Adkins D, Ingham M, Ding L, Van Tine BA.

Oncotarget 2021; 12:534-548

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells., Rogers LC, Zhou J, Baker A, Schutt CR, Panda PK, Van Tine BA.

Cancer & Metabolism 2021 9:4

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming., Brashears CB, Barlin M, Ehrhardt WR, Rathore R, Schultze M, Tzeng SC, Van Tine BA, Held JM

Cell Death Dis. 2020 Aug 20;11(8):662

PHGDH as a mechanism for resistance in metabolically-driven cancers., Rathore R, Schutt CS, Van Tine BA.

Cancer Drug Resist 2020;3

Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma., Robinson AM, Rathore R, Redlich NJ, Adkins DR, VanArsdale T, Van Tine BA, Michel LS.

Cell Death Dis. 2019 Nov 14;10(11):867

Arginine starvation and Docetaxel induce c-Myc-driven hENT1 surface expression to overcome gemcitabine resistance in ASS1-negative tumors., Prudner BC, Rathore R, Robinson A, Godec A, Change SF, Hawikins WG, Hirbe AC, Van Tine BA

Clin Cancer Res 2019 Aug 15;25(16):5122-5134

Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers., Rogers L., Van Tine BA

Cancer Drug Resist 2019 Jun 14; 2:516-526

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L.Gao Q, et al.

Cell Rep. 2018 Apr 3; 23(1):227-238

Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas.  Prudner BC, Sun F, Kremer JC, Xu J, Huang C, Sai KKS, Morgan Z, Leeds H, McConathy J, Van Tine BA. Prudner BC, et al. Theranostics. 2018 Mar 7;8(8):2107-2116.

Theranostics. 2018 Mar 7;8(8):2107-2116

Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma. Redlich N, Robinson AM, Nickel KP, Stein AP, Wheeler DL, Adkins DR, Uppaluri R, Kimple RJ, Van Tine BA, Michel LS.Redlich N, et al

Cell Death Dis. 2018 Jan 5; 9(1):5

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect.  Kremer JC, Van Tine BA., 2017 

Mol Cell Oncol. 2017 Mar 1;4(3)

Arginine deprivation inhibits the Warburg effect and upregulates glutamine anaplerosis and serine biosynthesis in ASS1-deficient cancers., Kremer JC, Prudner BC, Lange SE, Bean GR, Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K, Shelton L, Li A, Morgan Z, Bomalaski JS, Tsukamoto T, McConathy J, Michel LS, Held JM, Van Tine BA
Cell Rep 2017 Jan 24;18(4):991-100

A phase II study of tivozanib in patients with metastatic and nonresectable soft-tissue sarcomas
Agulnik M, Costa RL, Milhem M, Rademaker AW, Prunder BC, Daniels D, Rhodes BT, Humphreys C, Abbinanti S, Nye L, Cehic R, Polish A, Vintilescu C, McFarland T, Skubitz K, Robinson S, Okuno S, Van Tine BA
Ann Oncol 2017 Jan; 28(1):121-127

Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma
Dickson MA, Mahoney MR, Tap WD, D’Angelo SP, Keohan ML, Van Tine BA, Agulnik M, Horvath LE, Nair JS, Schwartz GK
Ann Oncol 2016 Oct;27(10):1855-60

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
Bean GR, Kremer JC, Prudner BC, Schenone AD, Yao JC, Schultze MB, Chen DY, Tanas MR, Adkins DR, Bomalaski J, Rubin BP, Michel LS, Van Tine BA
Cell Death Dis 2016 Oct 13;7(10):e2406

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic
Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG
Oncotarget 2016 Jun 7;7(23):33529-41

For a complete list of publications, see PubMed or Scopus.