Developmental Genetics and Genomics in Mammals

We are seeking motivated graduate and undergraduate students!

What’s new?

Welcome Shiori!

Dr. Shiori Kinoshita joined our lab as a postdoc, focusing on uncovering the genetic mechanisms behind pregnancy complications using genomics and computational analysis.

Enhancers are non-coding gene regulatory elements that regulate the spatial and temporal specificity of gene expression.  

Our lab’s goal is to understand the function of enhancers in placental and skeletal development, disease, and evolution using functional genomics and mouse genetics.

Questions

Over 90% of disease-associated variants identified in Genome-wide Association Studies (GWAS) are located in non-coding regions. How do these mutations contribute to disease development?

Mammalian limb skeletal structure displays remarkable diversity across species. Which gene regulatory elements are responsible for these species-specific differences?