Research Publications
Brenner JL, Schedl, T. Germline stem cell differentiation entails regional control of cell fate regulator GLD-1 in Caenorhabditis elegans. 2016, Genetics, 202:1085-1103. Brenner and Schedl 2016_PDF Brenner and Schedl 2016_Supplement_PDF
Howe KL, Bolt BJ, Cain S, Chan J. et al. WormBase 2016: expanding to enable helminth genomic research. Nucleic Acids Res. 44:D774-D780
Rastogi, S, Borgo, B, Pazdernik, N, Fox, PM, Mardis, ER, Kohara, Y, Havranek, J, Schedl, T, C. elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase. 2015, G3, 5:2719-2728. PDF
Fox, PM, Schedl, T. Analysis of germline stem cell differentiation following loss of GLP-1 Notch activity in C. elegans, 2015, Genetics, 201:167-184. PDF
Hou, X, Zhang, L, Han, L, Ge, J, Ma, R, Zhang, X, Moley, K, Schedl, T, Wang, Q. Differential function of pyruvate dehydrogenease kinases during mouse ooctye maturation. 2015, J. Cell Sci, 128:2319-2329. PDF
Zhang, L, Han, L, Ma, R, Hou, X, Yu, Y, Sun, S, Xu, Y, Schedl, T, Moley, K, Wang, Q. Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes. 2015, Cell Cycle, In Press PDF
Ma, R, Hou, X, Zhang, L, Sun, S, Schedl, T, Moley, K, Qiang Wang, Q. Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes. 2014, FASEB Journal, 28:4026-4035. PDF
Zhang, L, Hou, X, Ma, R, Moley, K, Schedl, T, Wang, Q. Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. 2014, FASEB Journal, 28:1435 – 1445. PDF
Harris TW, Baran J, Bieri T, Cabunoc A, et al. WormBase 2014: new views of curated biology. 2014 Nucleic Acids Res. 42:D789-93. PDF
Arur, S, and Schedl, T. Generation and purification of highly-specific antibodies for detecting post-translationally modified proteins in vivo. 2014; Nature Protocols, 9:375-395. PDF
Taylor, CM, Wang, Q, Rosa, BA, Huang, S, Powell, K, Schedl, T, Pearce, EJ, Abubucker, S, Mitreva, M. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. 2013; PLoS Pathogens, 9:e1003505. PDF
Luzzo, KM, Wang, Q, Purcell, SH, Chi, M, Jimenez, PT, Grinder, N, Schedl, T, Moley, KH. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. 2012; PLoS One, 7:e49217. PDF
Wang, Q. Chi, M, Schedl, T. and Moley, K. An intercellular pathway for glucose transport into mouse oocytes. 2012; American Journal of Physiology – Endocrinology and Metabolism, 302:E1511-1518. PDF
Wang, C, Wilson-Berry, L, Schedl, T, and Hansen, D. TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. 2012; Developmental Dynamics, 241:505-521. PDF
Arur, S, Ohmachi, M, Berkseth, M, Nayak, S, Hansen, D, Zarkower, D, and Schedl, T. MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex determination module. 2011; Developmental Cell, 20:677-688. PDF Supplement
Fox, P, Vought, V, Hanazawa, M, Lee, M-H, Maine, E, and Schedl, T. Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. 2011; Development, 138:2223-2234. PDF Supplement
Green, R, Kao, H, Audhya A, Arur, S, Schulman, M, Schloissnig, S, Niessen, S, Laband, K, Wang, S, Hyman, A, Desai, A, Schedl, T, Piano, F. Gunsalus, K. Oegema, K. A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue. 2011; Cell, 145:470-482. PDF
Rangarajan, A, Schedl, T, Yook, K, Chan, J, Haenel, S, Otis, L, Faelten, S, DePellegrin-Connelly, T, Isaacson, R, Skrzypek, M, Cherry, M, Sternberg, P, and Muller, H-M. Towards an interactive article: intergrating journals and biological databases. 2011; BMC Bioinforamtics, 12:175. PDF
Wang Q, A. Frolova, K. Adastra, S. Purcell, E. Schoeller, M. Chi, T. Schedl, and Moley, K. Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. 2010; PLoS ONE, 5:e15901-e15911. PDF
Kerins, JA, Hanazawa, M, Dorsett, M, Schedl, T. PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans. Developmental Dynamics. 2010, 239:1555-1572 PDF
Howell, K, Arur, S, Schedl, T, and Sundaram, M. EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in C. elegans. Genetics. 2010 184: 899–913 PDF
Dorsett, M. and Schedl, T. A role for dynein in the inhibition of germ cell proliferative fate. Molecular Cell Biology. 2009 29:6128-6139. PDF
Dorsett, M., B. Westland and T. Schedl. METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans. Genetics. 2009 183:233-247. PDF
Wang, Q, Ratchford, A, Chi, M, Schoeller, E, Frolova, A, Schedl, T, and Moley, K. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Molecular Endocrinology. 2009 23:1603-1612. PDF
Arur, S, Ohmachi, M, Nayak, S, Hayes, M, Miranda, A, Hay, A, Golden, A, and Schedl, T. Multiple ERK substrates execute single biological processes in C. elegans germline development. Proc. Nat Acad. Sci. 2009 106:4776-4781. PDF Supplement
Hillier, L, Marth, G, Quinlan, A, Dooling, D, Fewell, G, Barnett, D, Fox, P, Glasscock, J, Hickenbotham, M, Huang, W, Magrini, V, Richt, R, Sander, S, Stewart, D, Stromberg, M, Tsung, E, Wylie, T, Schedl, T, Wilson, R, and Mardis, E. Whole Genome Sequencing and Variant Discovery in C. elegans. Nature Methods. 2008 5:183-8. PDF
Lee, M. H, M. Ohmachi, S. Arur, S. Nayak, R. Francis, Church, D, Lambie, E, and Schedl, T. Multiple functions and dynamic activation of MPK-1 ERK signaling in C. elegans germline development. Genetics. 2007 177:2039-2062. PDF
Jantsch, V, Tang, L, Pasierbek, P, Penkner, A, Nayak, S, Baudrimont, A, Schedl, T. Gartner, A, and Loidl, J. C. elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing. 2007; Molecular Biology of the Cell. 2007 18:4911-4920. PDF Supplement
Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann R, Hengartner M, Schedl T, Gartner A. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell. 2005 Feb 11;120(3):357-68. PDF
Nayak S, Goree J, Schedl T. fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis. PLoS Biol. 2005 Jan;3(1):e6. Epub 2004 Dec 28. PDF
Tian X, Hansen D, Schedl T, Skeath JB. Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development. 2004 Dec;131(23):5807-15. PDF
Lee MH, Schedl T. Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans. Genes Dev. 2004 May 1;18(9):1047-59. Epub 2004 Apr 22. PDF
Hansen D, Hubbard EJ, Schedl T. Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline. Dev Biol. 2004 Apr 15;268(2):342-57. PDF
Wiederkehr C, Basavaraj R, Sarrauste de Menthiere C, Hermida L, Koch R, Schlecht U, Amon A, et al. GermOnline, a cross-species community knowledgebase on germ cell differentiation. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D560-7. PDF
Hansen D, Wilson-Berry L, Dang T, Schedl T. Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development. 2004 Jan;131(1):93-104. Epub 2003 Dec 3. PDF
Primig M, Wiederkehr C, Basavaraj R, Sarrauste de Menthiere C, Hermida L, Koch R, Schlecht U, et al. GermOnline, a new cross-species community annotation database on germ-line development and gametogenesis. Nat Genet. 2003 Dec;35(4):291-2. PDF
Ohmachi M, Rocheleau CE, Church D, Lambie E, Schedl T, Sundaram MV. C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr Biol. 2002 Mar 5;12(5):427-33. PDF
Nayak S, Santiago FE, Jin H, Lin D, Schedl T, Kipreos ET. The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Curr Biol. 2002 Feb 19;12(4):277-87. PDF
Hsu V, Zobel CL, Lambie EJ, Schedl T, Kornfeld K. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics. 2002 Feb;160(2):481-92. PDF
Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell. 2001 Oct 5;107(1):27-41. PDF
Lee MH, Schedl T. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev. 2001 Sep 15;15(18):2408-20. PDF Supplement
Miller MA, Nguyen VQ, Lee MH, Kosinski M, Schedl T, Caprioli RM, Greenstein D. A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation. Science. 2001 Mar 16;291(5511):2144-7. PDF
Clifford R, Lee MH, Nayak S, Ohmachi M, Giorgini F, Schedl T. FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. Development. 2000 Dec;127(24):5265-76. PDF
Kuwabara PE, Lee MH, Schedl T, Jefferis GS. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Genes Dev. 2000 Aug 1;14(15):1933-44. PDF
McCarter J, Bartlett B, Dang T, Schedl T. On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans. Dev Biol. 1999 Jan 1;205(1):111-28. PDF
Berry LW, Westlund B, Schedl T. Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development. 1997 Feb;124(4):925-36. PDF
McCarter J, Bartlett B, Dang T, Schedl T. Soma-germ cell interactions in Caenorhabditis elegans: multiple events of hermaphrodite germline development require the somatic sheath and spermathecal lineages. Dev Biol. 1997 Jan 15;181(2):121-43. PDF
Jones AR, Francis R, Schedl T. GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development. Dev Biol. 1996 Nov 25;180(1):165-83. PDF
Crowder CM, Shebester LD, Schedl T. Behavioral effects of volatile anesthetics in Caenorhabditis elegans. Anesthesiology. 1996 Oct;85(4):901-12. ABSTRACT
Iwasaki K, McCarter J, Francis R, Schedl T. emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation. J Cell Biol. 1996 Aug;134(3):699-714. PDF
Kloek AP, McCarter JP, Setterquist RA, Schedl T, Goldberg DE. Caenorhabditis globin genes: rapid intronic divergence contrasts with conservation of silent exonic sites. J Mol Evol. 1996 Aug;43(2):101-8. PDF
Jones AR, Schedl T. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 1995 Jun 15;9(12):1491-504. PDF
Francis R, Maine E, Schedl T. Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway. Genetics. 1995 Feb;139(2):607-30. PDF
Francis R, Barton MK, Kimble J, Schedl T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics. 1995 Feb;139(2):579-606. PDF
Graham PL, Schedl T, Kimble J. More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans. Dev Genet. 1993;14(6):471-84. PDF
Seydoux G, Schedl T, Greenwald I. Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Cell. 1990 Jun 15;61(6):939-51. PDF
Schedl T, Graham PL, Barton MK, Kimble J. Analysis of the role of tra-1 in germline sex determination in the nematode Caenorhabditis elegans. Genetics. 1989 Dec;123(4):755-69. PDF
Schedl T, Kimble J. fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans. Genetics. 1988 May;119(1):43-61. PDF
Barton MK, Schedl TB, Kimble J. Gain-of-function mutations of fem-3, a sex- determination gene in Caenorhabditis elegans. Genetics. 1987 Jan;115(1):107-19. PDF
Selected Reviews, Methods & Book Chapters:
Lee, M-H. and Schedl, T. C. elegans STAR proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development. In Post-transcriptional regulation by STAR proteins: control of RNA metabolism in Development and Disease. Edited by Volk, T. and Atrzt. 2010 PDF
Hansen, D. and Schedl, T. The regulatory network controlling the proliferation – meiotic entry decision in the C. elegans germ line. In Current Topics in Developmental Biology. 2006, 76:185-215. PDF
Ellis, R. and Schedl, T. Sex determination in the germ line. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.82.1 2006 PDF
Lee, R. and Schedl, T: RNA-binding proteins. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.79.1 2006 PDF
Lee, M.-H. and Schedl, T. RNA in situ hybridization of dissected gonads. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.107.1 2006 PDF
Seydoux G, Schedl T. The germline in C. elegans: origins, proliferation, and silencing. Int Rev Cytol. 2001;203:139-85. Review. ABSTRACT
Schedl T. Developmental genetics of the germline. In The Nematode Caenorhabditis elegans II. Edited by Riddle, D, Blumenthal, T, Meyer B and Priess J. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 1997 241-269.
Additional Research Publications By Members While In The Laboratory
Goldstein, J, Glossip, D, Nayak, S, Kornfeld, K. The CRAL/TRIO and GOLD Domain Protein CGR-1 Promotes Ras Mediated Signaling in C. elegans. Genetics. 2006 172: 929 – 942. PDF
Vought V, Ohmachi, M, Lee, M-H, Maine, E. EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/Notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis elegans. Genetics. 2005. 170:1121-1132. PDF
Maine, E, Hansen, D, Springer, D, Vought V. Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate. Genetics. 2004. 168:817-830. PDF
Kelly, W., Schaner, C, Dernburg, A, Lee, M-H, Kim, S, Villeneuve, A, Reinke, V. X-chromosome silencing in the germline of C. elegans. Development. 2002 129:479-492. PDF