Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
Journal of Clinical Investigation | May 2020
Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D.
Neurology Genetics | April 2019
A toxic imbalance of Hsp70s in Saccharomyces cerevisiae is caused by competition for cofactors.
Molecular Microbiology | June 2017
Prion-associated toxicity is rescued by elimination of cotranslational chaperones.
PLoS Genetics | November 2016
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D.
Human Molecular Genetics | September 2015
Prion strains and amyloid polymorphism influence phenotypic variation.
PLoS Pathogens | September 2014
Structural variants of yeast prions show conformer-specific requirements for chaperone activity.
Molecular Microbiology | July 2014
Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.
Journal of Biological Chemistry | July 2014
Extracellular environment modulates the formation and propagation of particular amyloid structures.
Molecular Microbiology | March 2014
Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities.
Molecular Microbiology | February 2014
Regulation of the Hsp104 middle domain activity is critical for yeast prion propagation.
PLoS ONE | January 2014
Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype.
Journal of Cell Biology | October 2013
Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variants.
Prion | September 2013
Analysis of the [RNQ+] prion reveals stability of amyloid fibers as the key determinant of yeast prion variant propagation.
Journal of Biological Chemistry | July 2010
The Sua5 protein is essential for normal translational regulation in yeast.
Molecular and Cellular Biology | January 2010
Heterologous prion interactions are altered by mutations in the prion protein Rnq1p.
Journal of Molecular Biology | May 2009
Mutants of the Paf1 complex alter phenotypic expression of the yeast prion.
Molecular Biology of the Cell | February 2009
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
PLoS Genetics | February 2009
Prion protein insertional mutations increase aggregation propensity but not fiber stability.
BMC Biochemistry | March 2008
Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.
Molecular and Cellular Biology | August 2007
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