In the Thorek Research Laboratory we are fully committed to Open Access publishing. We are grateful to our public and private funding sources and acknowledge that maximum impact for our discoveries is through barrier-free availability to all.

2021


Practical considerations for quantitative clinical SPECT/CT imaging of alpha particle emitting radioisotopes. Benabdallah N, Scheve W, Dunn N, Silvestros D, Schelker P, Abou D, Jammalamadaka U, Laforest R, Li Z, Liu J, Ballard DH, Maughan NM, Gay H, Baumann B, Hobbs RF, Rogers B, Iravani A, Jha AK, Dehdashti F, Thorek DLJ. Theranostics. 2021; 11(20):9721-9737. doi: 10.7150/thno.63860. PMID: 34815780.


Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice. Thompson JM, Ashbaugh AG, Wang Y, Miller RJ, Pickett JE, Thorek DLJ, Sterling RS, Miller LS.. J. Orthop Surgery and Research. 2021 Sep 14. doi: 10.1186/s13018-021-02594-0. PMID: 34521424.


Blind Image Restoration Enhances Digital Autoradiographic Imaging of Radiopharmaceutical Tissue Distribution. Lu P, Benabdallah N, Jiang W, Simons BW, Zhang H, Hobbs RF, Ulmert D, Baumann B, Pachynski RK, Jha AK, Thorek DLJ. J. Nuclear Medicine. 2021 ASAP. doi: 10.2967/jnumed.121.262270. PMID: 34385337.


Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2. Hua Z, Zhang, H, Zhou N, Ding J, Jiang J, Liu T, Liu Z, Wang F, Zhang Q, Zhang Z, Yan S, Li L, Benabdallah N, Jin H, Liu Z, Thorek DLJ, Yang X, Yang Z. Adv. Science 2021 ASAP. doi: 10.1002/advs.202100965. PMID: 34174177.


Longitudinal measurement of subcutaneous and intratibial human prostate cancer xenograft growth and response to ionizing radiation by plasma Alu and LINE-1 ctDNA: A comparison to standard methods. Mishra A, Zennami K, Velarde E, Thorek DLJ, Yegnasubramanian S, DeWeese TL, Lupold SE. The Prostate. 2021 (4) 9. doi: 10.1002/pros.24171. PMID: 34032307.


Improved Radium-223 Therapy with Combination Epithelial Sodium Channel Blockade. Abou DS, Fears A, Summer L, Longtine M, Benabdallah N, Riddle RC, Ulmert D, Michalski J, Wahl RL, Chesner D, Doucet M, Zachos N, Simons B, Thorek DL. J Nucl Med. 2021 (4) 9. doi: 10.2967/jnumed.121.261977. PMID: 33837069.


Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand. Abou DS, Thiele NA, Gutsche NT, Villmer A, Zhang H, Woods JJ, Baidoo KE, Escorcia FE, Wilson JJ, Thorek DLJ. Chem Sci. 2021 (10). https://doi.org/10.1039/D0SC06867E PMID: 34163647.


PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates. Veach DR, Storey CM, Lückerath K, Braun K, von Bodman C, Lamminmäki U, Kalidindi T, Strand SE, Strand J, Altai M, Damoiseaux R, Zanzonico P, Benabdallah N, Pankov D, Scher HI, Scardino P, Larson SM, Lilja H, McDevitt MR, Thorek DLJ, Ulmert D. Clin Cancer Res. 2021 (7) 27.
doi: 10.1158/1078-0432.CCR-20-3614 PMID: 33441295.

2020


Prostate Cancer Theranostics – An Overview. Abou D, Benabdallah N, Jiang W, Peng L, Zhang H, Villmer A, Longtine MS, Thorek DLJ. Front Oncol. 2020 Jun 5;10:884. doi: 10.3389/fonc.2020.00884. PMID: 32582550; PMCID: PMC7290246.


Preclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223. Abou DS, Rittenbach A, Tomlinson RE, Finley PA, Tsui B, Simons BW, Jha AK, Ulmert D, Riddle RC, Thorek DLJ. Cancer Biother Radiopharm. 2020 Sep;35(7):520-529. doi: 10.1089/cbr.2019.3308. Epub 2020 Mar 17. PMID: 32182119; PMCID: PMC7475100.

MILabs Radium SPECT

2019


Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma. Hanaford AR, Alt J, Rais R, Wang SZ, Kaur H, Thorek DLJ, Eberhart CG, Slusher BS, Martin AM, Raabe EH. Trans Oncol. 2019 (12) 10. doi: 10.1016/j.tranon.2019.05.013 PMID: 31340195.


Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects. Velho PI, Qazi F, Hassan S, Carducci MA, Denmeade SR, Markowski MC, Thorek DLJ, DeWeese TL, Song DY, Tran PT, Eisenberger MA, Antanorakis ES. Eur Urol. 2019 (76) 2. doi: 10.1016/j.eururo.2018.09.040 PMID: 30293905.


Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ. Cancer Res. 2019 (7) 14. doi: 10.1158/0008-5472.CAN-18-2931 PMID: 31123087


PSMA expression in the Hi‐Myc model; extended utility of a representative model of prostate adenocarcinoma for biological insight and as a drug discovery tool. Simons BW, Turtle NF, Ulmert DH, Abou DS, Thorek DLJ. Prostate. 2019 (79) 6. doi: 10.1002/pros.23770 PMID: 30656716.


Tumor‐infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer? Krueger TE, Thorek DLJ, Meeker AK, Isaacs JT, Brennen WN. Prostate. 2019 (79) 3. doi: 10.1002/pros.23738 PMID: 30488530


Harnessing androgen receptor pathway activation for targeted alpha particle radioimmunotherapy of breast cancer. Thorek DLJ, Ku AT, Mitsiades N, Veach D, Watson PA, Metha D, Strand SE, Sharma SK, Lewis JS, Abou DA, Lilja HG, Larson SM, McDevitt MR, Ulmert D. Clin Cancer Res. 2019 (25) 2. doi: 10.1158/1078-0432.CCR-18-1521 PMID: 30254080


Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics. Timmermand OV, Elgqvist J, Beattie KA, Örbom A, Larsson E, Ericksson SE, Thorek DLJ, Beattie BJ, Tran TA, Ulmert D, Strand SE. Theranostics. 2019 (8) 9. doi: 10.7150/thno.31179 PMID: 31149033

2018


Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe. Pastrana FR, Thompson JM, Heuker M, Hoekstra H, Diller CA, Ortines RV, Ashbaugh AG, Pickett JE, Linssen MD, Bernthal NM, Francis KP, Buist G, van Oosten M, van Dam GM, Thorek DLJ, Miller LS, van Dijl JM. Virulence. 2018 (1) 9. doi: 10.1080/21505594.2017.1403004 PMID: 29166841.


Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy. Marciscano AE, Ghasemzadeh A, Nirschl TR, Theodros D, Kochel CM, Francica BJ, Muroyama Y, Anders RA Sharabi AB, Velarde E, Mao W, Chaudhary KR, Chaimowitz MG, Wong J, Selby MJ, Thudium KB, Korman AJ, Ulmert D, Thorek DLJ, DeWeese TL, Drake CG. Clin Cancer Res. 2018 (24) 20. doi: 10.1158/1078-0432.CCR-17-3427 PMID: 29898992.


Role of noninvasive molecular imaging in determining response. Marciscano AE, Thorek DLJ. Adv Rad Onc. 2018 (3) 4.
doi: 10.1016/j.adro.2018.07.006 PMID: 30370353.


Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets. Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DLJ, Miller LS. JCI Insight. 2018 3(17): e121737. doi: 10.1172/jci.insight.121737 PMID: 30185667.


Concise Review: Mesenchymal Stem Cell‐Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise. Kreuger TE, Thorek DLJ, Denmeade SR, Isaacs JT, Brennen WN. Stem Cells. 2018 (7) 9. doi: 10.1002/sctm.18-0024 PMID: 30070053.


Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson. Pak JW, Kang J, Valentine H, Loew LM, Thorek DLJ, Boctor EM, Wong DF, Kang JU. Biomed Opt Exp. 2018 (9) 8. doi: 10.1364/BOE.9.003915 PMID: 30338164.


The impact of age on radium-223 distribution and an evaluation of molecular imaging surrogates. Jiang W, Ulmert D, Simons BW, Abou DS, Thorek DLJ. Nucl Med Biol. 2018 Jul-Aug;62-63:1-8. doi: 10.1016/j.nucmedbio.2018.05.003. Epub 2018 May 8. PMID: 29800797; PMCID: PMC6054814.


Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone. Pickett JE, Thompson JM, Sadowska A, Tkaczyk C, Sellman BR, Minola A, Corti D, Lanzavecchia A, Miller LS, Thorek DLJ. Bone Research. 2018 (6) 13. doi: 10.1038/s41413-018-0014-y PMID: 29707402.


Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer. McDevitt MR, Thorek DLJ, Hashimoto T, Gondo T, Veach DR, Sharma SK, Kalidindi TM, Abou DS, Watson PA, Beattie BJ, Timmermand OV, Strand SE, Lewis JS, Scardino PT, Scher HI, Lilja HG, Larson SM, Ulmert D. Nat Comms. 2018 (9) 1629. doi: 10.1038/s41467-018-04107-w PMID: 29691406.


Long-term prediction of prostate cancer diagnosis and death using PSA and obesity related anthropometrics at early middle age. Assel MJ, Gerdtsson A, Thorek DLJ, Carlsson SV, Malm J, Scardino PT, Vickers A, Lilja H, Ulmert D. Oncotarget. 2018 (9) 5. doi: 10.18632/oncotarget.22981 PMID: 29464033.


Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment. van Voss MRH, Vesuna F, Bol GM, Afzal J, Tantravedi S, Bergman Y, Kammers K, Lehar M, Malek R, Ballew M, ter Hoeve N, Abou D, Thorek D, Berlinicke C, YAzdankhah M, Sinha D, Le A, Abrahams R, Tran PT, van Diest PJ, Raman V. Oncogene. 2018 (37) 63. doi: 10.1038/onc.2017.308 PMID: 28869602.

2017


Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes. Kim SP, Frey JL, Li Z, Kushwaha P, Zoch ML, Tomlinson RE, Da H, Aja S, Noh HL, Kim JK, Hussain MA, Thorek DLJ, Wolfgang MJ, Riddle RC. PNAS. 2017 (114) 52. doi: 10.1073/pnas.1707876115 PMID: 29229807.


In vivo immuno-targeting of an extracellular epitope of membrane bound preferentially expressed antigen in melanoma (PRAME). Pankov D, Sjöström L, Kalindindi T, Lee SG, Sjöström K, Gardner R, McDevitt MR, O’Reilly R, Thorek DLJ, Larson SM, Veach D, Ulmert D. Oncotarget. 2017 (8) 39. doi: 10.18632/oncotarget.19579 PMID: 29229807.


Carbon nanotubes exhibit fibrillar pharmacology in primates.Alidori S, Thorek DLJ, Beattie BJ, Ulmert D, Almeida BA, Monette S, Scheinberg DA, McDevitt MR. PLOS One. 2017 doi: 10.1371/journal.pone.0183902 PMID: 28846728.


Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner.Kim SP, Li Z, Zoch ML, Frey JL, Bowman CE, Kushwaha P, Ryan KA, Goh BC, Scafidi S, Pickett JE, Faugere MC, Kershaw EE, Thorek DLJ, Clemens TL, Wolfgang MJ, Riddle RC. JCI Insight. 2017 (2) 16. doi: 10.1172/jci.insight.92704 PMID: 28814665.


Listening to membrane potential: photoacoustic voltage-sensitive dye recording. Zhang HK, Yan P, Kang J, Abou DS, Le HND, Jha A, Thorek DLJ, Kang JU, Rahmim R, Wong DF, Boctor EM, Loew LM. J Biomed Opt. 2017 (22) 4. doi: 10.1117/1.JBO.22.4.045006 PMID: 28394000.


A Radium-223 microgenerator from cyclotron-produced trace Actinium-227. DS Abou, J Pickett, JE Mattson, DLJ Thorek. Appl Radiat Isotop. 2017 (119) 36. doi: 10.1016/j.apradiso.2016.10.015 PMID: 27835737.