CURRENTLY RECRUITING:

Neonatal Predictors of Anxiety Disorders (N-PAD)

We are looking for pregnant mothers 18 years or older in their third trimester. There are 5 visits total across 2 years; the first visit takes place during pregnancy and can be completed virtually. The second visit takes place shortly after birth; your child will receive an MRI scan and you will be asked to complete surveys during this visit. The final 3 follow-up visits take place when your child is 4 months, 14 months, and 24 months old–during these appointments, you will be asked to completed surveys and tasks with your child. You will earn up to $350 for completion of the study. If interested, please call or text (314) 312-2684, or email NPAD@wustl.edu, and someone will be in touch to determine if you are eligible. You may also visit https://redcap.wustl.edu/redcap/surveys/?s=48CM7LMLE9 to determine if you are eligible for this study; if eligible, a research team member will reach out to you!

Pilot Attention and Error Processing Neuroimaging in Youth and Adolescents

Participants, 8 to 12 years of age, are needed for a research study. The purpose of this study is to understand how children with and without anxiety disorders pay attention to stimuli in their environment. Participants must be 8 to 12 years old, with or without anxiety disorder. There are 1 to 2 study visits with an MRI scan. Up to $125 is provided. Contact Jennifer Harper at EarlyAnxietyLab@wustl.edu or (314) 286-2697.

Other Research Studies:

Attention in Anxiety and Depression

The purpose of this study is to examine stimulus-driven attention (involuntarily orienting towards newly appearing stimuli) and attention biases (preferential attention towards negative versus neutral stimuli) in children with anxiety disorders, children with depression, and typically developing children. We are interested in both general attention changes as well as changes in functional brain networks that are involved in guiding attention. Participants were interviewed, completed a computer task that was designed to obtain measures of (1) stimulus-driven attention and (2) attention biases towards faces with angry or sad versus neutral expressions. A subset of children were invited to participate in functional magnetic resonance imaging (fMRI) studies designed to investigate attentional networks.

We are currently finished recruiting for this study and are in the second phase which is a 2-year follow up. We are  having children come back for an in-person office assessment that is exactly like the first in-person assessment. Participants are also asked to do another MRI scan if they had completed one 2 years prior.

Novel Anxiety Treatment

The purpose of the Novel Anxiety Treatment Study is to see the efficacy and feasibility of a novel computer-based cognitive training program that is designed to retrain a brain system associated with anxiety disorders. We are hoping that this cognitive training program will help alleviate symptoms of anxiety in children.

There are 12 visits associated with participating in this study. First, participants are interviewed and then we have children complete a computer task. We track the children’s eye movements while they complete the computer game. We then invite a subset of our participants to complete a fMRI scan. Then, the treatment portion of the study is twice a week for four weeks, where the child completed the cognitive training program which again, is a simple computer task. After the completion of the cognitive training, we then have children come in for another in-person assessment as well as another fMRI scan.

We are still actively recruiting for this study. If your child struggles with anxiety and you are interested, please see the recruitment page or contact Jennifer Harper (314)286-2697 jenniferharper@wustl.edu

Infant Brain Network

The purpose of The Infant Brain Networks Study is to characterize alterations in functional brain networks in newborn infants at high versus low risk for anxiety disorders. We are comparing the structure and function of brain networks in newborn infants of mothers with versus without a past history of an anxiety disorder. We are also working to identify variation in brain network structure and function in newborns that predicts anxious temperament in early infancy.

Participants for this study are being recruited through an ongoing study (eLABE) at Washington University School of Medicine. We have participants complete two visits. At the first visit, we will take a series of pictures of infant’s brains using functional magnetic resonance imaging while the infant listens to noises. We then will have mothers and children participate in one in-person assessments when the child is 12 months old. We will measure the child’s temperament by watching his/her responses to a series of toys.