Summary The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping—individual-specific analysis of highly sampled human participants—we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. […]
Category: Publications Resulting from McDonnell Funding
Spatial and Temporal Organization of the Individual Human Cerebellum
This article was originally published by Scott Marek, Joshua S. Siegel, Evan M. Gordon, Ryan V. Raut, Caterina Gratton, Dillan J. Newbold, Mario Ortega, Timothy O. Laumann, Babatunde Adeyemo, Derek B. Miller, Annie Zheng, Katherine C. Lopez, Jeffrey J. Berg, Rebecca Coalson, Annie L. Nguyen, Donna Dierker, Andrew N. Van, Catherine R. Hoyt, Kathleen B. […]
Effect of sleep on overnight CSF amyloid-β kinetics
This article was originally published by Brendan Lucey, Terry Hicks, Jennifer McLeland, Cristina Toedebusch, Jill Boyd, Donald Elbert, Bruce Patterson, Jack Baty, John Morris, Vitaliy Ovod, Kwasi Mawuenyega, & Randall Bateman. Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase […]
Ultrasound modulates ion channel currents
This article was originally published by Jan Kubanek, Jingyi Shi, Jon Marsh, Di Chen, Cheri Deng & Jianmin Cui Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating […]
Neuronal remapping and circuit persistence in economic decisions
This article published by Jue Xie & Camillo Padoa Schioppa The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental question […]