Effect of sleep on overnight CSF amyloid-β kinetics

This article was originally published by Brendan Lucey, Terry Hicks, Jennifer McLeland, Cristina Toedebusch, Jill Boyd, Donald Elbert, Bruce Patterson, Jack Baty, John Morris, Vitaliy Ovod, Kwasi Mawuenyega, & Randall Bateman. Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase […]

Ultrasound modulates ion channel currents

This article was originally published by Jan Kubanek, Jingyi Shi, Jon Marsh, Di Chen, Cheri Deng & Jianmin Cui   Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by […]

Neuronal remapping and circuit persistence in economic decisions

This article published by Jue Xie & Camillo Padoa Schioppa The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental question […]