Selected Publications

  • Siyan Cao*#, Khai M Nguyen*, Kaiming Ma, Xin Yao, Ta-Chiang Liu, Malek Ayoub, Jalpa Devi, Yizhou Liu, Radhika Smith, Matthew Silviera, Steven R Hunt, Paul E Wise, Matthew G Mutch, Sean C Glasgow, William C Chapman Jr., Michelle Cowan, Mathew A Ciorba, Marco Colonna#, Parakkal Deepak#. Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn’s Disease. bioRxiv. 2024.11.08.620717. *Co-first author; #Co-senior author
  • Siyan Cao*#, Khai Nguyen*, Kaiming Ma, Xiaotang Du, Xiuli Liu, Alina Ulezko Antonova, Richard P. Rood, Anas Gremida, Chien-Huan Chen, Alexandra Gutierrez, Deborah C. Rubin, Martin H. Gregory, Mate Gergely, Rodney D. Newberry, Guadalupe Oliva Escudero, Katherine Huang, Natalia Jaeger, Marina Cella, Nicholas O. Davidson, Matthew A. Ciorba, Parakkal Deepak, Marco Colonna#. Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets. Gastroenterology. In press. *Co-first author; #Co-senior author
  • Siyan Cao, Jose L. Fachi, Alina Ulezko Antonova, Qianli Wang, Zhangying Cai, Randal J. Kaufman, Matthew A. Ciorba, Parakkal Deepak, Marco Colonna. IRE1a-XBP1 sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease. Journal of Clinical Investigation. 2024 May 9:e174198.
  • Siyan Cao, Parakkal Deepak, Marco Colonna. Pathogenesis of Perianal Fistulizing Crohn’s Disease: current knowledge, gaps in understanding and future research directions. Journal of Crohn’s and Colitis. 2023 Jun 16;17(6):1010-1022.
  • Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L Poliani, Wandy L Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H Ellebedy, Susan Gilfillan, Gordon D Brown, David M Holtzman, Simone Brioschi, Marco Colonna. Cell. 2022:185 (22), 4153-4169. e19. 
  • Vincent Peng*, Siyan Cao*, Tihana Trsan, Jennifer K Bando, Julian Avila-Pacheco, John L Cleveland, Clary Clish, Ramnik J Xavier, Marco Colonna. Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proceedings of the National Academy of Sciences, USA. 2022: 119 (45), e2214900119. *Co-first author.
  • Ru-Xuan Chen, Siyan Cao, Li-Dan Zhao, Hua-Xia Yang. Obstructive uropathy associated with rheumatoid arthritis successfully treated with steroids and immunosuppressive therapy. Medicine. 2019: 98 (50).
  • Siyan Cao. Cellular stress responses and gut microbiota in inflammatory bowel disease. Gastroenterology Research and Practice. 2018:7192646.
  • Siyan Cao. Epithelial ER stress in Crohn’s disease and ulcerative colitis. Inflammatory Bowel Diseases. 2016: 22 (4), 984-993.
  • Siyan Cao, Katherine L Luo, Lynn Shi. Endoplasmic reticulum stress interacts with inflammation in human diseases. Journal of Cellular Physiology. 2016: 231 (2), 288-294.
  • Katherine Luo, Siyan Cao. Endoplasmic reticulum stress in intestinal epithelial cell function and inflammatory bowel disease. Gastroenterology Research and Practice 2015: 328791.
  • Siyan Cao. Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease. Inflammatory Bowel Diseases. 2015: 21 (3), 636-644.
  • Siyan Cao, Randal J Kaufman. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & Redox Signaling. 2014: 21 (3), 396-413.
  • Siyan Cao, Miao Wang, Jane C Harrington, Brandy-Mengchieh Chuang, Lars Eckmann, Randal J Kaufman. Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for Paneth cell function and intestinal homeostasis in mice. Inflammatory Bowel Diseases. 2014: 20 (4), 712-722.
  • Siyan Cao, Ellen M Zimmermann, Brandy-Mengchieh Chuang, Benbo Song, Anosike Nwokoye, J Erby Wilkinson, Kathryn A Eaton, Randal J Kaufman. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013: 144 (5), 989-1000. e6.
  • Siyan Cao, Randal J Kaufman. Targeting endoplasmic reticulum stress in metabolic disease. Expert Opinion on Therapeutic Targets. 2013: 17 (4), 437-448.
  • Siyan Cao, Randal J Kaufman. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora? Inflammatory Bowel Diseases. 2013: 19 (3), E49-E50.
  • Justin Hassler, Siyan Cao, Randal J Kaufman. IRE1, a double-edged sword in pre-miRNA slicing and cell death. Developmental Cell. 2012: 23 (5), 921-923.
  • Siyan Cao, Benbo Song, Randal J Kaufman. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflammatory Bowel Diseases. 2012: 18 (9), 1735-1742.
  • Siyan Cao, Randal J Kaufman. Unfolded protein response. Current Biology. 2012: 22 (16), R622-R626.
  • Siyan Cao, Randal J Kaufman. iRhoms: ERADicating the messenger in growth control signaling. Developmental Cell. 2011: 20 (4), 414-416.
  • Randal J Kaufman, Siyan Cao. Inositol‐requiring 1/X‐box‐binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Molecular Medicine. 2010: 2 (6), 189-192.

Please click here for my NIH Bibliography.