We study disease-relevant cell and organ signaling pathways in inflammatory bowel disease (IBD, which includes Crohn’s disease and ulcerative colitis) using molecular and cell biology, multi-omics technologies (e.g., single-cell and spatial transcriptomics, proteomics, whole-genome/exome sequencing, metagenomics), murine models, and human tissues.
We currently have four major focuses: 1) Innate lymphoid cells (ILC) in murine IBD; 2) Innate immune mechanisms in perianal and fibrostenotic Crohn’s disease; 3) Multi-omics analyses of IBD-related complications, including Crohn’s of the pouch, perianal fistulizing CD, and microscopic colitis; 4) Biomarker discovery for IBD therapies (e.g., anti-IL-23s and JAK inhibitors) and diagnosis (e.g., fibrostenotic CD).
https://www.ncbi.nlm.nih.gov/myncbi/siyan.cao.2/bibliography/public/