Wang Q, Clark KM, Tiwari R, Raju N, Tharp GK, Rogers J, Harris AR, Raveendran M, Bosinger SE, Burdo TH, Silvestri G, Shan L. The CARD8 Inflammasome Dictates HIV/SIV Pathogenesis and Disease Progression. Cell. 2024 Feb 29;187(5):1223-1237.e16. Link
Li Y, Gao H, Clark KM, Shan L. IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells. JCI Insight. 2023 Apr 10;8(7):e166292. Link
Sungur CM, Wang Q, Ozanturk AN, Gao H, Schmitz AJ, Cella M, Yokoyama WM, Shan L. Human NK cells confer protection against HIV-1 infection in humanized mice. J Clin Invest. 2022 Dec 15;132(24). Link
Clark KM, Kim JG, Wang Q, Gao H, Presti RM, Shan L. CARD8 Inflammasome Sensitization through Chemical Inhibition of DPP9 Promotes Clearance of HIV-1-infected Cells. Nature Chemical Biology 2023 Apr;19(4):431-439.. Link
Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, Harlan GH, DeSelm CJ, Presti RM, Kutluay SB, Shan L. CARD8 is an inflammasome sensor for HIV-1 protease activity. Science. 2021 Mar 19;371(6535):eabe1707. doi: 10.1126/science.abe1707. Link
Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells. Science. 2021 Mar 5;371(6533):1019-1025. Link
Shan L, Deng K, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, Ke R, Flavell RA, Siliciano JD, Siliciano RF. Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection. Immunity. 2017 Oct 17;47(4):766-775. Link
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Bhiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 2015 Jan 15;517(7534):381-5. Link
Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity. 2012 Mar. 36(3): 491-501 Link
Additional publications (see PubMed bibliography)