Featured Publications

Refreshable Nanobiosensor Based on Organosilica Encapsulation

Refreshable Nanobiosensor Based on Organosilica Encapsulation
Implantable and wearable biosensors that enable monitoring of biophysical and biochemical parameters over long durations are highly attractive for early and presymptomatic diagnosis of pathological conditions and timely clinical intervention. Poor stability of antibodies used as biorecognition elements and the lack of effective methods to refresh the biosensors upon demand without severely compromising the functionality […]

Bone marrow adipose tissue does not express UCP1

Bone marrow adipose tissue does not express UCP1
Adipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1Cre+/DTA+). Despite […]

Shared Autonomic Pathways Connect Bone and Adipose Tissue.

Shared Autonomic Pathways Connect Bone and Adipose Tissue.
Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The […]

Peripheral Neuropathy as a Component of Diabetic Skeletal Disease

Peripheral Neuropathy as a Component of Diabetic Skeletal Disease
The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk. In addition, we address therapeutic and experimental considerations to guide patient care and future research evaluating the emerging relationship […]


  • Tratwal J, Labella R, Bravenboer N, Kerckhofs G, Douni E,Scheller EL, Badr S, Karampinos DC, Beck-Cormier S, Palmisano B, Poloni A, Moreno-Aliaga MJ, Fretz J, Rodeheffer MS, Boroumand P, Rosen CJ, Horowitz MC, van der Eerden BCJ, Veldhuis-Vlug AG, Naveiras O. (2020) Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society. Feb 28;11:65. doi: 10.3389/fendo.2020.00065. 
  • Gupta R, Luan J, Chakrabartty S, Scheller EL, Morrissey J, Singamaneni S. (2020) Refreshable Nanobiosensor Based on Organosilica Encapsulation of Biorecognition Elements. ACS Appl Mater Interfaces. Feb 5;12(5):5420-5428. 


  • Wee NKY, Lorenz MR, Bekirov Y, Jacquin MF, Scheller EL. (2019) Shared Autonomic Pathways Connect Bone Marrow and Peripheral Adipose Tissues Across the Central Neuraxis. Front Endocrinol. Sep 27;10:668. doi: 10.3389/fendo.2019.00668.
  • Beeve AT, Brazill JB, Scheller EL. (2019) Peripheral neuropathy as a component of skeletal disease in diabetes. Curr Osteoporos Rep. Aug 7. doi: 10.1007/s11914-019-00528-8
  • Brazill JB, Beeve AT, Craft CS, Ivanusic JJ, Scheller EL. (2019) Nerves in bone: evolving concepts in pain and anabolism. J Bone Miner Res. Jun 27. doi: 10.1002/jbmr.3822. 
  • McCabe IC, Fedorko A, Meyers MG Jr, Leinninger G, Scheller E, McCabe LR. Novel leptin receptor signaling mutants identify location and sex-dependent modulation of bone density, adiposity, and growth. (2019) J Cell Biochem. 120(3):4398-4408. PMCID: PMC6336499
  • Zou W, Rohatgi N, Brestoff JR, Zhang Y, Scheller EL, Craft CS, Brodt MD, Migotsky N, Silva MJ, Harris CA, Teitelbaum SL. (2019) Congenital lipodystrophy induces severe osteosclerosis. PLoS Genet. Jun 24;15(6):e1008244. PMCID: 31233501
  • Robles H, Park S, Joens MS, Fitzpatrick JAJ, Craft CS, Scheller EL. (2019) Characterization of the bone marrow adipocyte niche with three-dimensional electron microscopy. Bone. 118:89-98. PMCID: PMC6063802
  • Scheller EL, Khandaker S, Learman BS, Cawthorn WP, Anderson LM, Pham HA, Robles H, Wang Z, Li Z, Parlee SD, Simon BR, Mori H, Bree AJ, Craft CS, MacDougald OA. (2019) Bone marrow adipocytes resist lipolysis and remodeling in response to β-adrenergic stimulation. Bone. 118:32-41. PMCID: PMC6062480
  • Alazzawi Y, Aono K, Scheller EL, Chakrabartty S. Exploiting Self-Capacitances for Wireless Power Transfer. (2019) IEEE Trans Biomed Circuits Syst. 13(2):425-434.
  • Silva MJ, Eekhoff JD, Patel T, Kenney-Hunt JP, Brodt MD, Steger-May K, Scheller EL, Cheverud JM. Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice. (2019) J Bone Miner Res. doi: 10.1002/jbmr.3648.


  • Turecamo SE, Walji TA, Broekelmann TJ, Williams JW, Ivanov S, Wee NK, Procknow JD, McManus MR, Randolph GJ, Scheller EL, Mecham RP, Craft CS. (2018) Contribution of metabolic disease to bone fragility in MAGP1-deficient mice. Matrix Biol. 67:1-14.
  • Bauerle KT, Hutson I, Scheller EL, Harris CA. (2018) Glucocorticoid Receptor Signaling Is Not Required for In Vivo Adipogenesis. Endocrinology. 159(5):2050-2061
  • Li Z, Hardij J, Bagchi DP, Scheller EL, MacDougald OA. (2018) Development, regulation, metabolism and function of bone marrow adipose tissues. Bone. 110:134-140.
  • Craft CS, Li Z, MacDougald OA, Scheller EL. (2018) Molecular differences between subtypes of bone marrow adipocytes. Current Molecular Biology Reports. Mar;4(1):16-23.


  • Craft CS, Wee NK, Scheller EL. (2017)  Adipocytes and Bone. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 8th Edition. 
  • Scheller EL, Hildebolt C, Civitelli R. (2017)  Oral Manifestations of Metabolic Bone Diseases. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 8th Edition. 
  • Cawthorn WP, Scheller EL. (2017) Editorial: Bone Marrow Adipose Tissue: Formation, Function, and Impact on Health and Disease. Front Endocrinol. May 29;8:112. 


  • Cawthorn WP, Scheller EL, Parlee SD, Pham HA, Learman BS, Redshaw CM, Sulston RJ, Burr AA, Das AK, Simon BR, Mori H, Bree AJ, Schell B, Krishnan V, MacDougald OA. (2016) Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia. Endocrinology. 157(2):508-521. PMCID: PMC4733126
  • Scheller EL, Khoury B, Moller KL, Wee NK, Khandaker S, Kozloff KM, Abrishami SH, Zamarron BF, Singer K. (2016) Changes in skeletal integrity and marrow adiposity during high-fat diet and after weight-loss. Front Endocrinol. Jul 27;7:102. PMCID: PMC4961699
  • Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS. (2016) Marrow adipose tissue expansion coincides with insulin resistance in MAGP1-deficient mice. Front Endocrinol. Jun 30;7:87. PMCID: PMC4928449
  • Sulston RJ, Learman BS, Zhang B, Scheller EL, Parlee SD, Simon BR, Mori H, Bree AJ, Wallace RJ, Krishnan V, MacDougald OA, Cawthorn WP. (2016) Increased circulating adiponectin in response to thiazolidinediones: investigating the role of bone marrow adipose tissue. Front Endocrinol. Sep 21;7:128. PMCID: PMC5030308
  • Scheller EL, Burr A, MacDougald OA, Cawthorn WP. (2016) Inside out: Bone marrow adipose tissue as a source of circulating adiponectin. Adipocyte. DOI: 10.1080/21623945.2016.1149269
  • Scheller EL, Cawthorn WP, Burr AA, Horowitz MC, MacDougald OA. (2016) Marrow adipose tissue: Trimming the Fat. Trends Endocrinol Metab. 27(6):392-403. PMCID: PMC4875855
  • Craft CS and Scheller EL. (2016) Evolution of the Marrow Adipose Tissue Microenvironment. Calcif Tissue Int. Doi: 10.1007/s00223-016-0168-9