Madelyn Lorenz unveils the Neuroskeletal Atlas at ASBMR

After 4 years of hard work, Madelyn Lorenz was selected to present her new Neuroskeletal Atlas of the Mouse Limb as a featured oral presentation at the American Society for Bone and Mineral Research (ASBMR) annual meeting. The Atlas is currently in preparation for publication and we anticipate having it available for preliminary use through […]

Xiao Zhang wins two research awards for work on marrow fat

Xiao Zhang won two of the prestigious awards for research at the recent BMA2020 meeting. After an independent committee review, his oral presentation “Fat in a fatless mouse: a novel origin of maladapted bone marrow adipocytes with age and disease” won 1st place in the best abstract category. In addition, his 2nd abstract “Neural contributions […]

Big happenings at the BMA2020 meeting

The 6th Annual Meeting of the Bone Marrow Adiposity Society (BMA2020), co-organized by our very own Dr. Scheller, was quite the event. With 55 abstracts, 11 invited speakers, 205 attendees, and even a live trivia event hosted by American Ninja Warrior’s Alex Weber – it was one for the books. Congratulations to Dr. Scheller on […]

Welcome to Mr. David Mingyu Shin

David Shin is currently a junior and was previously majoring in Economics and Accounting at Washington University in St. Louis prior to following the call to change his major to Biology. We welcome David to the lab and look forward to working with him to develop his scientific skills.

Refreshable Nanobiosensor Based on Organosilica Encapsulation

Implantable and wearable biosensors that enable monitoring of biophysical and biochemical parameters over long durations are highly attractive for early and presymptomatic diagnosis of pathological conditions and timely clinical intervention. Poor stability of antibodies used as biorecognition elements and the lack of effective methods to refresh the biosensors upon demand without severely compromising the functionality […]

Bone marrow adipose tissue does not express UCP1

Adipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1Cre+/DTA+). Despite […]

Welcome to Dr. Alexander Ahmadi and Xiao Zhang

A warm welcome to two new trainees.  Dr. Alexander Ahmadi joins us from the Saint Louis University (SLU) periodontics residency program.  Dr. Ahmadi will be working with us on the oral biosensor project.  Xiao Zhang is currently visiting as a rotation student from the BME program at Washington University. Xiao will investigate the properties and […]

Postdoctoral fellow Dr. Natalie Wee presents at ASBMR

Dr. Wee was selected for a podium presentation for her work entitled “Shared autonomic pathways connect bone marrow and peripheral adipose tissues across the central neuraxis”. She presented during the session on ‘Bone-Lipid Connections’ at the recent 2019 ASBMR meeting. This work was also recently accepted for publication in Frontiers in Endocrinology. Congratulations Natalie!

Congratulations and farewell to Dr. Craft

Dr. Craft has worked with us since the founding of the lab in 2016 and her contributions have helped to shape the lab into what it is today. We are thankful for her science and her leadership during the past few years. We wish her all the best as she transitions into her new career!

Peripheral Neuropathy as a Component of Diabetic Skeletal Disease

The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk. In addition, we address therapeutic and experimental considerations to guide patient care and future research evaluating the emerging relationship […]

Madelyn Lorenz and Alec Beeve present at ISAN 2019

Members of the lab recently attended the 11th Congress of the International Society for Autonomic Neuroscience to share their science with other SPARC investigators and the autonomic neuroscience community. The lab presented two posters including “Nerves of the Bone: Foundational Neuroanatomical Mapping of Skeletal Nerves from Bone to Brain” (Lorenz) and “Acute and chronic responses […]

Exploiting Self-Capacitances for Wireless Power Transfer.

Conventional approaches for wireless power transfer rely on the mutual coupling (near-field or far-field) between the transmitter and receiver transducers. In this paper, we show that when the operational power-budget requirements are in the order of microwatts, a self-capacitance (SC)-based power delivery has significant advantages in terms of the power transfer-efficiency, receiver form-factor, and system […]

Bone marrow adipocytes resist lipolysis and β-adrenergic stimuli

Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the tibia, resists loss of neutral lipid with acute, 48-hour fasting in rats. The mechanisms underlying this phenomenon and its seemingly distinct regulation from peripheral white […]

Jennifer Brazill begins T32 fellowship

Dr. Jennifer Brazill, a post-doctoral fellow with previous training in neurobiology, was appointed to the Skeletal Disorders Training Program T32 in the Division of Bone & Mineral Diseases at Washington University. For her fellowship, Dr. Brazill will study the physiologic integration of the neural and musculoskeletal systems in states of health and diabetes.

Evolution of the Marrow Adipose Tissue Microenvironment

In this review, we discuss the initial evolution of MAT in vertebrate lineages while emphasizing comparisons to the development of peripheral adipose, hematopoietic, and skeletal tissues. We then apply these evolutionary clues to define putative functions of MAT. Lastly, we explore the regulation of MAT by two major components of its microenvironment, the extracellular matrix […]