Dr. Scheller was elected to serve as a 2020 – 2022 board member for the International Society of Bone Morphometry (ISBM). She will work with the society and board to develop the field of skeletal imaging and morphology, including hosting the 2022 ISBM meeting in Denmark.
Mr. Beeve was selected as a recipient of the Department of Bioengineering travel award to attend the BMES conference in San Diego, CA where he will present his work on the acute and chronic regulation of bone by bioelectric stimulation of the sciatic nerve. Congratulations Alec!
Ms. Ivana Shen was awarded a 2020 BioSURF fellowship to pursue her work on the relationship between nerve quality and bone health in mice and humans with diabetes. Congratulations, Ivana!
Dr. Scheller was hosted by Dr. Tamara Alliston and the to UCSF Department of Orthopaedic Surgery to present the ongoing work in the laboratory pertaining to neural regulation of skeletal pathophysiology as part of the CCMBM seminar series. She then traveled to the UCLA School of Dentistry to visit with Dr. Paul Krebsbach and to […]
David Shin is currently a junior and was previously majoring in Economics and Accounting at Washington University in St. Louis prior to following the call to change his major to Biology. We welcome David to the lab and look forward to working with him to develop his scientific skills.
Implantable and wearable biosensors that enable monitoring of biophysical and biochemical parameters over long durations are highly attractive for early and presymptomatic diagnosis of pathological conditions and timely clinical intervention. Poor stability of antibodies used as biorecognition elements and the lack of effective methods to refresh the biosensors upon demand without severely compromising the functionality […]
Adipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1Cre+/DTA+). Despite […]
A warm welcome to two new trainees. Dr. Alexander Ahmadi joins us from the Saint Louis University (SLU) periodontics residency program. Dr. Ahmadi will be working with us on the oral biosensor project. Xiao Zhang is currently visiting as a rotation student from the BME program at Washington University. Xiao will investigate the properties and […]
Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The […]
Dr. Scheller attended the XIVth Congress of the International Society of Bone Morphometry as an invited speaker and enjoyed the opportunity to share our work on nerves in bone and neural regulation of bone marrow adiposity.
Dr. Wee was selected for a podium presentation for her work entitled “Shared autonomic pathways connect bone marrow and peripheral adipose tissues across the central neuraxis”. She presented during the session on ‘Bone-Lipid Connections’ at the recent 2019 ASBMR meeting. This work was also recently accepted for publication in Frontiers in Endocrinology. Congratulations Natalie!
Dr. Craft has worked with us since the founding of the lab in 2016 and her contributions have helped to shape the lab into what it is today. We are thankful for her science and her leadership during the past few years. We wish her all the best as she transitions into her new career!
Dr. Scheller presented on neural regulation of marrow fat and its connections across the central neuraxis as the final talk of the 5th International Meeting on Bone Marrow Adiposity in Odense, Denmark.
The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk. In addition, we address therapeutic and experimental considerations to guide patient care and future research evaluating the emerging relationship […]
Members of the lab recently attended the 11th Congress of the International Society for Autonomic Neuroscience to share their science with other SPARC investigators and the autonomic neuroscience community. The lab presented two posters including “Nerves of the Bone: Foundational Neuroanatomical Mapping of Skeletal Nerves from Bone to Brain” (Lorenz) and “Acute and chronic responses […]
This review provides a historical perspective of the field of skeletal neurobiology which highlights the diverse yet interconnected nature of nerves and skeletal health, particularly in the context of bone anabolism and pain.
In addition to successfully passing his qualifying examination, Alec Beeve was recently appointed to a competitive graduate student fellowship position on the Skeletal Disorders Training Program (T32). Congratulations to Alec on his exam and his research fellowship to study the effects of acute and chronic bioelectric nerve stimulation on skeletal health.
Congratulations to Nasja on her summer research fellowship to study the interplay and relationships between diabetic neuropathy and skeletal disease.
Conventional approaches for wireless power transfer rely on the mutual coupling (near-field or far-field) between the transmitter and receiver transducers. In this paper, we show that when the operational power-budget requirements are in the order of microwatts, a self-capacitance (SC)-based power delivery has significant advantages in terms of the power transfer-efficiency, receiver form-factor, and system […]
The bone marrow adipocyte (BMA) exists in a microenvironment containing unique populations of hematopoietic and skeletal cells. To study this microenvironment at the sub-cellular level, we performed a three-dimensional analysis of the ultrastructure of the BMA niche with focused ion beam scanning electron microscopy (FIB-SEM).
Dr. Jennifer Brazill, a post-doctoral fellow with previous training in neurobiology, was appointed to the Skeletal Disorders Training Program T32 in the Division of Bone & Mineral Diseases at Washington University. For her fellowship, Dr. Brazill will study the physiologic integration of the neural and musculoskeletal systems in states of health and diabetes.
Collaborative research team developing biological sensors that would analyze saliva, send information electronically to doctors.
Hero Robles discusses the nuances of bone marrow adiposity with the next generation of researchers. (Washington University Undergraduate Research Day, 2017)