Selected Publications

  1. Rubenstein RC, Egan ME, Zeitlin PL. In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. J Clin Invest. 1997;100(10):2457-65. PMCID:PMC508446 PMID:9366560
  2. Rubenstein RC, Zeitlin PL. A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. Am J Respir Crit Care Med. 1998;157(2):484-490. PMID:9476862
  3. Goldfarb SB, Kashlan OB, Watkins JN, Suaud L, Yan W, Kleyman TR, Rubenstein RC. Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proc Natl Acad Sci U S A. 2006;103(15):5817-22.  PMCID:PMC1458656 PMID:16585520
  4. Suaud L, Miller K, Alvey L, Yan W, Robay A, Kebler C, Kreindler JL, Guttentag S, Hubbard MJ, Rubenstein RC. ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells. J Biol Chem. 2011;286(24):21239-53. PMCID:PMC3122184 PMID:21525008
  5. Chanoux RA, Robay A, Shubin CB, Kebler C, Suaud L, Rubenstein RC. Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum. J Biol Chem. 2012;287(23):19255-65. PMCID:PMC3365957 PMID:22496374
  6. Grumbach Y, Bikard Y, Suaud L, Chanoux RA, Rubenstein RC. ERp29 regulates epithelial sodium channel functional expression by promoting channel cleavage. Am J Physiol Cell Physiol. 2014;307(8):C701-9. PMCID:PMC4199997 PMID:24944201
  7. Bikard Y, Viviano J, Orr MN, Brown L, Brecker M, Jeger JL, Grits D, Suaud L, Rubenstein RC. The KDEL receptor has a role in the biogenesis and trafficking of the epithelial sodium channel (ENaC). J Biol Chem. 2019;294(48):18324-18336. PMCID:PMC6885628 PMID:31653700
  8. *Viviano J, *Brecker M, Ferrara-Cook C, Suaud L, Rubenstein RC. ERp29 as a regulator of Insulin biosynthesis. PLoS One. 2020;15(5):e0233502. PMCID:PMC7239452 PMID:32433667
  9. *Brecker M, *Khakhina S, *Schubert TJ, *Thompson Z, Rubenstein RC. The Probable, Possible, and Novel Functions of ERp29 Front Physiol.2020;11:574399. doi:10.3389/fphys.2020.574339 PMCID:PMC7506106 PMID:33013490
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