PET-RTRC Seminar Speaker | Uwe Haberkorn, MD

Uwe Haberkorn, MD | Heidelberg University | August 31, 2021 @ 12:00pm CDT | “Design and problems of tumor targeting tracers”

Technological advances in molecular biology and biotechnology are increasingly used for the development of new tumor targeting tracers. In oncology, major progress has recently been achieved with peptidic and small molecule compounds. This relies on the identification and validation of new target structures in close conjunction with the application of new techniques for the development of new biocompatible molecules. These are based on either rational design or high throughput methods such as phage and ribosome display. Their further evaluation and optimization consists in the characterization of the structure-function relationships and subsequent improvement with respect to binding, internalization and biodistribution of corresponding analogues. The concept will be shown for display techniques using peptide libraries and rational design of a radiopharmaceutical targeting the fibroblast activation protein (FAP).

Seminar Speaker- Dr. Robert Mach | April 23 | 11:00am CDT

Talk Title: “PARP-1 Radiotracers for PET Imaging and Small Molecule Targeted Alpha Radiotherapeutics” PARP inhibitors (PARPi) have proven to be an important class of compounds for treating cancer patients having BRCA1/2 mutations or other deficiencies in homologous recombination repair. Unfortunately, ~50% of patients having BRCA1/2 mutations do not respond to PARPi, indicating that better biomarkers are needed to identify which patients are likely to benefit from this type of treatment…

Webinar: Tuesday, January 21, 2020 | 11:00 CST

Tuesday, Jan 21, 2020 11:00 AM – 12:00 PM CST

US First-in-Man Regulatory Requirements: Nuts and Bolts for CMC Preparation

Presenter: Sally W. Schwarz, RPh, MS, BCNP