Education
BS, Biochemistry and Molecular Biology
Brown University
Providence, RI
2007 – 2011
MD, Washington University School of Medicine,
St. Louis, MO
2011 – 2015
Residency
Resident, Washington University School of Medicine,
St. Louis, MO
2015 – 2022
Fellowship
Skull Base Neurosurgery Fellow
University of Pittsburgh Medical Center
Pittsburgh, PA
2023 – 2024
Post-Doctoral Research Fellow
Universitätsklinikum Heidelberg, German Cancer Research Center,
Laboratory of Felix Sahm, MD, PhD
Heidelberg, Germany
2022 – 2023
Post-Doctoral Research Fellow
Washington University School of Medicine, St. Louis, MO
Laboratory of Albert H. Kim, MD, PhD
2019 – 2021
Research Focus
The unifying theme of my research interests is multi-omic characterization of skull base tumors to identify mechanisms and markers of clinical behavior that can inform management of these tumors both inside and outside the operating room.
- I am investigating the molecular biology of multiply recurrent meningiomas and radiation resistant CNS WHO grade 2 meningiomas using whole exome, methylation and RNA sequencing, along with well validated cell line models of meningioma. My goal is to identify markers of treatment resistance and therapeutic targets to enhance our clinical management of recurrent meningiomas.
- I am characterizing the process of meningioma brain invasion using a multi-omic approach using a combination of single cell RNA sequencing, high resolution spatial transcriptomic analysis, and epigenetic analysis. My goal is to understand the molecular pathways involved in meningioma brain invasion with an eye towards facilitating identification of invasive meningiomas and developing novel therapeutic agents targeting these lesions.
- I am analyzing the epigenetic profile of pituitary neuroendocrine tumors (formerly pituitary adenoma) using bulk methylation array analysis. My goal is to use methylation profiling for early identification of locally invasive and distantly metastatic pituitary neuroendocrine tumors which can then be used to modify the post-operative surveillance and treatment of patients with pituitary adenomas.
Research Awards
The Walter L. Copeland Fund
December 1, 2023 – September 30, 2024
Title: Molecular characterization of brain invasive meningiomas
PI: Bhuvic Patel, MD
AANS William P. Van Wagenen Fellowship
July 1, 2022 – June 30, 2023
Title: Region-specific epigenetic analysis of meningiomas and their cell of origin
PI: Bhuvic Patel, MD
NIH R25 Research Training and Career Development Grant
July 1, 2019 – June 30, 2021
Title: Identifying biomarkers and mechanisms of radiation resistance in grade II meningiomas
PI: Bhuvic Patel, MD (Institution PI: Gregory J. Zipfel, MD)
Neurosurgery Research and Education Foundation (NREF)
July 1, 2019 – June 30, 2020
Title: Identifying biomarkers and mechanisms of radiation resistance in grade II meningiomas
PI: Bhuvic Patel, MD