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IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC).
Pachynski RK, Morishima C, Szmulewitz R, Harshman L, Appleman L, Monk P, Bitting RL, Kucuk O, Millard F, Seigne JD, Fling SP, Maecker HT, Duault C, Ramchurren N, Hess B, D’Amico L, Lacroix A, Kaiser JC, Morre M, Grégoire A, Cheever M, Yu EY, Fong L.
Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment
Pachynski RK, Wang P, Salazar N, Zheng Y, Nease L, Rosalez J, Leong WI, Virdi G, Rennier K, Shin WJ, Nguyen V, Butcher EC, Zabel BA
Single Cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer
Pachynski RK, Kim E, Miheecheva N, Kotlov N, Ramachandran A, Postovalova E, Galkin I, Svekolkin V, Lyu Y, Zou Q, Cao D, Gaut JP, Ippolito JE, Bagaev A, Bruttan M, Gancharova O, Nomie KJ, Tsiper M, Andriole GL, Ataullakhanov RI, Hsieh JJ
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- Clinical Results and Biomarker Analyses of Axitinib and TRC105 Versus Axitinib Alone in Patients With Advanced or Metastatic Renal Cell Carcinoma (TRAXAR)
Choueiri TK, Zakharia Y, Pal S, Kocsis J, Pachynski R, Poprach A, Nixon AB, Liu Y, Starr M, Lyu J, Owzar K, deShazo M, Lara P, Geczi L, Ho TH, Walsh M, Adams B, Robertson L, Darif M, Theuer C, Agarwal N
Oncologist 2021 Apr 7; [Epub ahead of print] - Single Cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer
Pachynski RK, Kim E, Miheecheva N, Kotlov N, Ramachandran A, Postovalova E, Galkin I, Svekolkin V, Lyu Y, Zou Q, Cao D, Gaut JP, Ippolito JE, Bagaev A, Bruttan M, Gancharova O, Nomie KJ, Tsiper M, Andriole GL, Ataullakhanov RI, Hsieh JJ
Clin Cancer Res 2021 Mar 26; [Epub ahead of print] - Active Surveillance of Metastatic Renal Cell Carcinoma: Results From a Prospective Observational Study (MaRCC)
Harrison MR, Costello BA, Bhavsar NA, Vaishampayan U, Pal SK, Zakharia Y, Jim HSL, Fishman MN, Molina AM, Kyriakopoulos CE, Tsao CK, Appleman LJ, Gartrell BA, Hussain A, Stadler WM, Agarwal N, Pachynski RK, Hutson TE, Hammers HJ, Ryan CW, Inman BA, Mardekian J, Borham A, George DJ
Cancer 2021 Mar 25; [Epub ahead of print] - Videos of Sipuleucel-T Programmed T Cells Lysing Cells That Express Prostate Cancer Target Antigens
Kibel AS, Inman BA, Pachynski RK, Vu T, Sheikh NA, Petrylak DP
J Natl Cancer Inst 2021 Feb 25; [Epub ahead of print] - Diagnostic Performance of (18)F-DCFPyL-PET/CT in Men With Biochemically Recurrent Prostate Cancer: Results From the CONDOR Phase 3, Multicenter Study
Morris MJ, Rowe SP, Gorin MA, Saperstein L, Pouliot F, Josephson DY, Wong JY, Pantel AR, Cho SY, Gage KL, Piert MR, Iagaru A, Pollard JH, Wong V, Jensen J, Lin T, Stambler N, Carroll P, Siegel BA, Wibmer AG, Durack JC, Solomon SB, Harb R, Pucar D, Sprenkle P, Beauregard JM, Beaulieu A, Buteau FA, Yamauchi D, Glaser S, Dorff TB, Narayan V, Fillare MA, Schubert E, Cooley G, Morris ZS, Langeland M, Pow-Sang JM, Yamoah K, Alva AS, Reichert Z, Spratt D, Davidzon G, Mari Aparici C, Moradi F, Tracy C, Behr S, Nguyen HG, Simko JP, Jennings JW, Michalski JM, Pachynski RK
Clin Cancer Res 2021 Feb 23; [Epub ahead of print] - Management of Muscle-Invasive Bladder Cancer During a Pandemic: Impact of Treatment Delay on Survival Outcomes for Patients Treated With Definitive Concurrent Chemoradiotherapy
Fischer-Valuck BW, Michalski JM, Harton JG, Birtle A, Christodouleas JP, Efstathiou JA, Arora VK, Kim EH, Knoche EM, Pachynski RK, Picus J, Rao YJ, Reimers M, Roth BJ, Sargos P, Smith ZL, Zaghloul MS, Gay HA, Patel SA, Baumann BC
Clin Genitourin Cancer 2021 Feb;19(1):41-46 - Immunotherapy and Immunotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer
Bansal D, Reimers MA, Knoche EM, Pachynski RK
Cancers (Basel) 2021 Jan 18;13(2) - A “Tail” of Immunotherapy in Metastatic Prostate Cancer
Pachynski RK
Eur Urol 2020 Dec;78(6):831-833 - Radiation and Checkpoint Inhibitor Immunotherapy Lead to Long Term Disease Control in a Metastatic RCC Patient With Brain Metastases
Levitin M, Ofori J, Shin WJ, Huang J, Daly M, Cao D, Pachynski R
Front Oncol 2020 Sep 23;10:566070 - Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial
Sharma P, Pachynski RK, Narayan V, Flechon A, Gravis G, Galsky MD, Mahammedi H, Patnaik A, Subudhi SK, Ciprotti M, Simsek B, Saci A, Hu Y, Han GC, Fizazi K
Cancer Cell 2020 Oct 12;38(4):489-499 - Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells Via Modulation of a Novel CMKLR1-Mediated Signaling Cascade
Rennier K, Shin WJ, Krug E, Virdi G, Pachynski RK
Clin Cancer Res 2020 Sep 15;26(18):5019-5035 - Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer
Dang HX, Chauhan PS, Ellis H, Feng W, Harris PK, Smith G, Qiao M, Dienstbach K, Beck R, Atkocius A, Qaium F, Luo J, Michalski JM, Picus J, Pachynski RK, Maher CA, Chaudhuri AA
JCO Precis Oncol 2020;4:680-713 - How Else Can We Approach Prostate Cancer Biomarker Discovery?
Drake RR, Angel PM, Wu J, Pachynski RK, Ippolito JE
Expert Rev Mol Diagn 2020 Feb;20(2):123-125 - Effectiveness of Postoperative Radiotherapy After Radical Cystectomy for Locally Advanced Bladder Cancer
Fischer-Valuck BW, Michalski JM, Mitra N, Christodouleas JP, DeWees TA, Kim E, Smith ZL, Andriole GL, Arora VK, Bullock A, Carmona R, Figenshau RS, Grubb RL, Guzzo TJ, Knoche EM, Malkowicz SB, Mamtani R, Pachynski RK, Roth BJ, Zaghloul MS, Gay HA, Baumann BC
Cancer Med 2019 Jul;8(8):3698-3709 - Immunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization
Reimers MA, Slane KE, Pachynski RK
Curr Urol Rep 2019 Sep 3;20(10):64 - Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment
Pachynski RK, Wang P, Salazar N, Zheng Y, Nease L, Rosalez J, Leong WI, Virdi G, Rennier K, Shin WJ, Nguyen V, Butcher EC, Zabel BA
Front Immunol 2019 May 8;10:983 - Magnetic Resonance Image Guided Stereotactic Body Radiation Therapy to the Primary Renal Mass in Metastatic Renal Cell Carcinoma
Rudra S, Fischer-Valuck B, Pachynski R, Daly M, Green O
Adv Radiat Oncol 2019 Apr 13;4(4):566-570 - Cabozantinib in Advanced Non-Clear-Cell Renal Cell Carcinoma: A Multicentre, Retrospective, Cohort Study
Martinez Chanza N, Xie W, Asim Bilen M, Dzimitrowicz H, Burkart J, Geynisman DM, Balakrishnan A, Bowman IA, Jain R, Stadler W, Zakharia Y, Narayan V, Beuselinck B, McKay RR, Tripathi A, Pachynski R, Hahn AW, Hsu J, Shah SA, Lam ET, Rose TL, Mega AE, Vogelzang N, Harrison MR, Mortazavi A, Plimack ER, Vaishampayan U, Hammers H, George S, Haas N, Agarwal N, Pal SK, Srinivas S, Carneiro BA, Heng DYC, Bosse D, Choueiri TK, Harshman LC
Lancet Oncol 2019 Apr;20(4):581-590 - A Propensity Analysis Comparing Definitive Chemo-Radiotherapy for Muscle-Invasive Squamous Cell Carcinoma of the Bladder Vs. Urothelial Carcinoma of the Bladder Using the National Cancer Database
Fischer-Valuck BW, Michalski JM, Contreras JA, Brenneman R, Christodouleas JP, Abraham CD, Kim EH, Arora VK, Bullock AD, Carmona R, Figenshau RS, Grubb R 3rd, Knoche EM, Pachynski RK, Picus J, Roth BJ, Sargos P, Andriole GL, Gay HA, Baumann BC
Clin Transl Radiat Oncol 2018 Dec 12;15:38-41 - Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention
Shin WJ, Zabel BA, Pachynski RK
Front Immunol 2018 Nov 30;9:2772 - Treatment of Advanced Prostate Cancer
Thomas TS, Pachynski RK
Mo Med 2018 Mar-Apr;115(2):156-161 - Chemerin Modulation of Tumor Growth: Potential Clinical Applications in Cancer
Shin WJ, Pachynski RK
Discov Med 2018 Aug;26(141):31-37 - Contemporary Management of the Newly Diagnosed Prostate Cancer Patient With Metastatic Disease at Presentation
Xu L, Pachynski RK
Curr Urol Rep 2018 Aug 13;19(10):79 - Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment
Gulley JL, Madan RA, Pachynski R, Mulders P, Sheikh NA, Trager J, Drake CG
J Natl Cancer Inst 2017 Apr 1;109(4) - Prostate, Bladder, and Kidney Cancer
Pachynski RK
In: DeVita, Hellman, and Rosenberg’s Cancer, Principles & Practice of Oncology Review (Govindan R, Morgensztern D, eds). Chapter 20. Lippincott Williams & Wilkins, 2016 - ASCO 2016: Genitourinary Highlights
Pachynski RK
Oncology Times 2016 Aug 25;38(16):24 - Holbrook Kohrt: In Memoriam (1977-2016)
Houot R, Pachynski R, Czerwinski DK, Goldstein MJ, Sagiv-Barfi I, Brody J, Muller AM, Marabelle A
Clin Cancer Res 2016 Jul 15;22(14):3695-6 - NK Cell Responses in Immunotherapy: Novel Targets and Applications
Pachynski RK, Kohrt HE
In: Novel Immunotherapeutic Approaches to the Treatment of Cancer: Drug Development and Clinical Application (Rennert P, ed). Chapter VII. Springer, 2016 - Leukocyte Trafficking: Can We Bring the Fight to the Tumor?
Pachynski R, Nazha J, Kohrt H
Discov Med 2016 Mar;21(115):205-212 - Phase II Study of Pazopanib and Paclitaxel in Patients With Refractory Urothelial Cancer
Narayanan S, Lam A, Vaishampayan U, Harshman L, Fan A, Pachynski R, Poushnejad S, Haas D, Li S, Srinivas S
Clin Genitourin Cancer 2016 Oct;14(5):432-437 - Evaluation of Tumor-Infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Pachynski RK, Scholz A, Monnier J, Butcher EC, Zabel BA
J Vis Exp 2015 Apr 13;(98) - The Chemoattractant Chemerin Suppresses Melanoma by Recruiting Natural Killer Cell Antitumor Defenses
Pachynski RK, Zabel BA, Kohrt HE, Tejeda NM, Monnier J, Swanson CD, Holzer AK, Gentles AJ, Sperinde GV, Edalati A, Hadeiba HA, Alizadeh AA, Butcher EC
J Exp Med 2012 Jul 30;209(8):1427-35 - Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance
Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, Nguyen L, Ghodsi A, Adler S, Butcher EC
Immunity 2012 Mar 23;36(3):438-50 - Extranodal Dissemination of Non-Hodgkin Lymphoma Requires CD47 and Is Inhibited by Anti-CD47 Antibody Therapy
Chao MP, Tang C, Pachynski RK, Chin R, Majeti R, Weissman IL
Blood 2011 Nov 3;118(18):4890-901 - CD137 Stimulation Enhances the Antilymphoma Activity of Anti-CD20 Antibodies
Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Muller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R
Blood 2011 Feb 24;117(8):2423-32 - Redirecting Migration of T Cells to Chemokine Secreted From Tumors by Genetic Modification With CXCR2
Kershaw MH, Wang G, Westwood JA, Pachynski RK, Tiffany HL, Marincola FM, Wang E, Young HA, Murphy PM, Hwu P
Hum Gene Ther 2002 Nov 1;13(16):1971-80 - Secondary Lymphoid-Tissue Chemokine (SLC) Stimulates Integrin Alpha 4 Beta 7-Mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Under Flow
Pachynski RK, Wu SW, Gunn MD, Erle DJ
J Immunol 1998 Jul 15;161(2):952-6 - Presentation of Integrins on Leukocyte Microvilli: A Role for the Extracellular Domain in Determining Membrane Localization
Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ
J Cell Biol 1997 Oct 20;139(2):563-71 - Structure-Function Analysis of the Integrin Beta 7 Subunit: Identification of Domains Involved in Adhesion to MAdCAM-1
Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ
J Immunol 1997 Aug 1;159(3):1497-505