Randal C. Paniello, MD, PhD, FACS

Otolaryngology—Head & Neck Surgery

Patients seen at

Center for Advanced Medicine
Ear, Nose and Throat Center
4921 Parkview Place
Suite A, Floor 11
St. Louis, MO 63110
(314) 362-7509
Fax: (314) 747-8687

Voice and Airway Center
Medical Office Bldg. 3
1020 N. Mason Rd.
Suite 205
Creve Coeur, MO 63141
(314) 362-7509
Fax: (314) 432-8208

Mailing address

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid, Campus Box 8115
St. Louis, MO 63110

Clinical interests

Dr. Paniello’s clinical interests include voice disorders (spasmodic dysphonia, hoarseness, whispering or strained voice, vocal cord paralysis, professional voice problems), reconstructive surgery (cancer or trauma), plastic surgery (nose, chin and cheek implants, hair, eyelid and lip augmentation), head and neck (tumors, lymph nodes, masses, biopsies) and general otolarygnology (deviated septum, tonsils, swallowing problems, snoring, sleep apnea).

View clinical profile »


  • Medical Degree: University Of Illinois, 1984
  • Residency: Otolaryngology, Head and Neck Surgery, Barnes Jewish Hospital, St. Louis, Missouri, 1990
  • Chief Resident: Otolaryngology, Head and Neck Surgery, Barnes Jewish Hospital, St. Louis, Missouri, 1990
  • Fellowship: McCollough Aesthetic Surgery Center, Birmingham, Alabama – Fellowship with E. Gaylon McCollough, MD, 1992
  • Doctorate Degree: Washington University, 2013

Licensure and board certification

  • Otolaryngology–Certified

Selected publications

  1. Vemula S, Xiao J, Zhao Y, Bastian R, Perlmutter J, Racette B, Paniello R, Wszolek Z, Uitti R, Van Gerpen J, Hedera P, Truong D, Blitzer A, Rudzińska M, Momcilovic D, Jinnah H, Frei K, Pfeiffer R, LeDoux M. A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia. Mol. Genet. Genomic Med. 2014, 2:261-72. PMID 24936516.
  2. Paniello RC, Rich JT, Debnath NL. Laryngeal adductor function in experimental models of recurrent laryngeal nerve injury. Laryngoscope; Epub 2014 Oct 4. doi: 10.1002/lary.24947. PMID 25283381.
  3. Paniello RC. Vocal fold paralysis: improved adductor recovery by vincristine blockade of posterior cricoarytenoid. Laryngoscope; Epub 2014 Sept 30. doi: 10.1002/lary.24951. PMID 25267697.
  4. Spataro EA, Grindler DJ, Paniello RC. Etiology and time to presentation of unilateral vocal fold paralysis. Otolaryngol. Head Neck Surg. 2014, 151:286-294. (Epub 2014 May 5.) PMID 24796331.
  5. Neely JG, Paniello RC, Graboyes EM, Sharon JD, Grindler DJ, Nussenbaum B. Practical Guide to understanding clinical research compliance. Otolaryngol. Head Neck Surg. 2014, 150: 716-721. PMID 24598406.
  6. Neely JG, Sharon JD, Graboyes EM, Paniello RC, Nussenbaum B, Grindler DJ, Dassopoulos T. Practical guide to understanding comparative effectiveness research (CER). Otolaryngol Head Neck Surg. 2013, 149:804-12. PMID 24098005.
  7. Paniello RC, Desai SC, Allen CT, Khosla SM. Endoscopic keel placement to treat and prevent anterior glottic webs. Ann Otol. Rhinol. Laryngol. 2013, 122:672-8. PMID 24358626.
  8. Neely JG, Graboyes E, Paniello RC, Sequeira SM, Grindler DJ. Practical guide to understanding the need for clinical prac-tice guidelines. Otolaryngol Head Neck Surg. 2013, 149:1-7. PMID 23625796.
  9. Neely JG, Cho Lieu JE, Sequeira SM, Graboyes E, Paniello RC, Nussenbaum B, Grinder DJ, Voelker CCJ. Practical guide to understanding multivariable analyses, part B: conjunctive con-solidation. Otolaryngol Head Neck Surg. 2013, 148(3):359-65. PMID 23264117.
  10. Neely JG, Paniello RC, Lieu JE, Voelker CC, Grindler DJ, Sequeira SM, Nussenbaum B. Practical Guide to Understanding Multivariable Analyses: Part A. Otolaryngol Head Neck Surg. 2013, 148:185-90. PMID 23034515.
  11. Paniello RC, Fraley PL, O’Bert R, Heintz C. Effect of hyperbaric oxygen therapy on a murine squamous cell carcinoma model. Head Neck; Epub 2013 Oct 25. doi: 10.1002/hed.23528. PMID 24166929.
  12. Paniello RC, Neely JG, Rich JT, Slattery EL, Voelker CC. Practical Guide to Choosing an Appropriate Data Display. Otolaryngol Head Neck Surg. 2011, 145:886-94. PMID 21975544.
  13. Paniello RC, Edgar JD, Kallogjeri D, Piccirillo JF. Medialization versus reinnervation for unilateral vocal fold paralysis: a multicenter randomized clinical trial. Laryngoscope 2011, 121:2172-9. PMID 21898419.
  14. Slattery EL, Voelker CC, Nussenbaum B, Rich JT, Paniello RC, Neely JG. A practical guide to surveys and question-naires. Otolaryngol. Head Neck Surg. 2011, 144: 831-7. PMID 21493322.
  15. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum. Genet.2010, 127:469-70. PMID 21488296.

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