My lab has put extensive efforts into developing easier methods to manipulate the C. elegans genome especially especially methods that permit the insertion of large DNA sequences at specific genomic positions. We have developed a FLP and Cre recombinase-mediated method for integrating large DNA fragments and a phiC31 recombinase-mediated techinique for recombining insertions from a trans to a cis configuration. In addition, we have also been developing bipartite reporter systems to simplify the development of high level expression transgenes in C. elegans regulated in time and space.