How do developing neurons organize themselves into networks that see?

The goal of our lab is to identify the structural and developmental principles that turn agglomerations of cells into image processing circuitry. At the core of our approach is circuit scale 3D electron microscopy (EM), an imaging technology that can reveal the precise pattern of synaptic connections within a network of neurons. Our work focuses on: 1) The Retina, where stereotyped structure/function relationships are ideal for relating patterns of synaptic connectivity to specific visual computations and 2) The LGN, a circuit that is immediately downstream to the retina and structurally analogous to the retina, but whose circuit structure is heavily dependent on developmental patterns of synaptic activity.