Systems and Synthetic Biology

We aim to understand microbial gene regulatory networks and engineer microbes for addressing energy, environmental, and health issues. Specifically, we are interested in developing synthetic biology tools, constructing genetic circuits, and engineering regulatory RNAs in diverse bacteria. Learn more

Tae Seok Moon





Postdoctoral research at MIT and University of California-San Francisco provided Dr. Moon with expertise in the design and construction of genetic circuits. As a graduate student at MIT, he learned how to construct and optimize novel metabolic pathways to produce biochemicals that can replace oil-based chemicals. Combining his research experiences with more than five years experience in the biotechnology industry, he envisions his career as transforming biology research from an “observation” approach to a “synthesis-based engineering” activity to address energy, environment and health issues. Learn more about Dr. Moon

Recent News & Announcements



 to Matt and Austin for their paper published: MB Amrofell, AG Rottinghaus and TS Moon. Engineering microbial diagnostics and therapeutics with smart control. Curr. Opin. Biotechnol. 66, 11-17. (2020) Link


Moon Research Group receives a grant from the National Science Foundation for “Unifying synthetic small regulatory RNAs.” Link

Congratulations to Kirsten for her paper published: K Davis and TS Moon. Tailoring microbes to upgrade lignin. Curr. Opin. Chem. Biol. 59, 23-29 (2020) Link


Our collaborative work was published: K Zhang, J Wei, K Huff Hartz, M Lydy, TS Moon, M Sander and KM Parker. Analysis of RNA interference (RNAi) biopesticides: double-stranded RNA (dsRNA) extraction from agricultural soils and quantification by RT-qPCR. Environ. Sci. Technol. 54, 4893−4902 (2020) Link


Our collaborative work was published: C Frankfater, WR Henson, A Juenger-Leif, M Foston, TS Moon, J Turk, JLF Kao, A Haas and F Hsu. Structural determination of a new peptidolipid family from Rhodococcus opacus and the pathogen Rhodococcus equi by multiple stage mass spectrometry. J. Am. Soc. Mass Spectrom. 31, 611−623 (2020) Link

Anastasiia Onyshchenko joins the group as a Graduate Rotation student. Welcome!



Congratulations to Austin and Matt for their paper accepted: AG Rottinghaus, MB Amrofell and TS Moon. Biosensing in smart engineered probiotics. Biotechnol. J. Link

Yifeng Hu and Chenggang Xi join the group as PhD students. Welcome!


Congratulations to Anamika & Drew for their paper accepted: A Chatterjee, DM DeLorenzo, R Carr and TS Moon. Bioconversion of renewable feedstocks by Rhodococcus opacus. Curr. Opin. Biotechnol. 64, 10-16 (2020) Link

Dr. Junyang Wang and Dr. Jinjin Diao join the group. Welcome!

Drew successfully defended his thesis. Congrats! Dr. DeLorenzo! We will miss you.

Yifeng Hu, Juya Jeon, and Chenggang Xi join the group as Graduate Rotation students. Welcome!


Dr. Kirsten Davis joins the group. Welcome!

Congratulations to Drew for his paper accepted: DM DeLorenzo and TS Moon. Construction of genetic logic gates based on the T7 RNA polymerase expression system in Rhodococcus opacus PD630. ACS Synth. Biol. 10.1021/acssynbio.9b00213 (2019) Link

Congratulations to Rhiannon for our collaborative work published: W Anthony, RR Carr, DM DeLorenzo, T Campbell, Z Shang, M Foston, TS Moon and G Dantas. Development of Rhodococcus opacus as a chassis for lignin valorization and bioproduction of high-value compounds. Biotechnol Biofuels. 12:192. (2019) Link

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