Electrochemistry and Umpolung Reactions: New Tools for Solving Synthetic Challenges of Structure and Location
Electrochemistry is a powerful tool for initiating new umpolung reactions. In this paper, two examples are provided. One demonstrates the use of electrochemistry for reversing the polarity of known functional groups and triggering carbon-carbon bond formation. The second demonstrates the use of electrochemistry for reversing the polarity of a chemical reagent, a technique that allows for spatially locating synthetic transformations on addressable chips.
Feili Tang, Ceng Chen, Kevin D. Moeller
Synthesis 2007, 3411-3420