Building Addressable Libraries: A Site-Selective Click-Reaction Strategy for Rapidly Assembling Mass Spec Cleavable Linkers

Cu(I)-catalyzed ‘‘click-reactions’’ were accomplished site-selectively on microelectrode arrays having either 1024 or 12,544 electrodes per cm². The triazole product generated served as an effective TOF-SIMS cleavable linker.Jennifer L. Bartels, Peng Lu, Amy Walker, Karl Maurer, and Kevin D. Moeller.
Chem. Comm. 2009, 5573 – 5575.