While many steps in an oxidative cyclization reaction can be important, it is the cyclization step itself that plays the central role. If this step does not proceed well, then optimization of the rest of the sequence is futile. We report here that the key to the cyclization is channeling the reaction down the correct pathway. Some reactions require the use of a radical pathway and some require the use of a radical cation pathway. An example of each is provided along with a strategy for accessing both pathways using a common intermediate.
Robert J. Perkins, Ruozhu Feng, Qingquan Lu, and Kevin D. Moeller*
Chin. J. Chem. 2019, 37, pp 672－678
Publication Date (Web): 08 May 2019