Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.

Haizhou Sun and Kevin D. Moeller
Org. Lett., 2002, 4 (9), pp 1547–1550