Tao’s paper is published in JCI Insight… and Ewa’s pic made the cover!!

Tao’s paper is published in JCI Insight… and Ewa’s pic made the cover!!
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis of the centrosome, a defect that can cause genome instability, aberrant ciliary signaling, and secretion of pro-inflammatory factors. Cystic cells […]

Ewa’s paper is published in EMBO Reports!

Ewa’s paper is published in EMBO Reports!
Mutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here, we examined the consequences of impaired centrosome duplication on kidney stromal progenitor cell growth, differentiation, and fate. Conditional deletion of the […]

Tao’s paper is published in Development!

Tao’s paper is published in Development!
Mutations that disrupt centrosome biogenesis or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet how centrosome dysfunction results in the kidney disease phenotypes remains unknown. Here, we examined the consequences of conditional knockout of the ciliopathy gene Cep120, essential for centrosome duplication, in the nephron and collecting duct progenitor niches of the mouse […]

A big welcome to our new Summer Scholar Arushi Katyal!

A big welcome to our new Summer Scholar Arushi Katyal!
Arushi is a sophomore at Boston College, and is joining the lab for 2 months as part of the WU Pediatric Center of Excellence in Nephrology (PCEN) Summer Scholar program. She will be investigating how defects in centrosome biogenesis affect the immune response during embryonic kidney development. Welcome to the lab!

Ewa’s new preprint about the effects of Cep120/centrosome loss in the kidney stromal progenitors is now on bioRxiv

Ewa’s new preprint about the effects of Cep120/centrosome loss in the kidney stromal progenitors is now on bioRxiv
Reciprocal signaling between progenitor cells of the stromal mesenchyme (SM), metanephric mesenchyme and ureteric bud is critical for proper mammalian kidney morphogenesis. Several of these signaling pathways are regulated by the centrosome, and its associated structure the primary cilium. Mutations in genes that disrupt centrosome biogenesis or function cause congenital kidney developmental defects and lead […]

Tao’s new preprint on the consequences of Cep120/centrosome loss in nephron progenitors during kidney development is now on bioRxiv

Tao’s new preprint on the consequences of Cep120/centrosome loss in nephron progenitors during kidney development is now on bioRxiv
Mutations that disrupt centrosome structure or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet, it remains unclear how mutations in proteins essential for centrosome biogenesis impact embryonic kidney development. Here, we examined the consequences of conditional deletion of a ciliopathy gene, Cep120, in the two nephron progenitor niches of the embryonic kidney. Cep120 loss led to […]

Our collaboration on roles of GEMC1/MCIDAS during multiciliogenesis is published in Cell Death and Disease

Our collaboration on roles of GEMC1/MCIDAS during multiciliogenesis is published in Cell Death and Disease
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequential action of the Geminin family transcriptional activators, GEMC1 and MCIDAS, that both interact with E2F4/5-DP1. How these factors activate […]

Our collaboration on the role of Cep120 in  axon development is published in Cell Reports

Our collaboration on the role of Cep120 in  axon development is published in Cell Reports
Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neurons have fewer somatic acetylated MTs restricted near the centrosome. At later stages, however, acetylated MTs spread out in soma and concentrate in growing […]