Dr. Gonzalez-Perez’s Publications

  1. Gonzalez-Perez V, Zhou Y, Ciorba Matthew A, Lingle CJ, The LRRC family of BK channel regulatory subunits: potential roles in health and disease, J Physiol. 2022 Jan 10. doi: 10.1113/JP281952
  2. Gonzalez-Perez V, Martinez-Espinosa PL, Sala-Rabanal M, Bharadwaj N, Xia XM, Chen AC, Alvarado D, Gustafsson JK, Hu H, Ciorba MA, Lingle CJ. Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3). doi: 10.1073/pnas.2019149118. PubMed PMID: 33431687; PubMed Central PMCID: PMC7826367.
  3. Gonzalez-Perez V, Lingle CJ. Regulation of BK Channels by Beta and Gamma Subunits. Annu Rev Physiol. 2019 Feb 10;81:113-137. doi: 10.1146/annurev-physiol-022516-034038. Review. PubMed PMID: 30742788; PubMed Central PMCID: PMC6380188.
  4. Gonzalez-Perez V, Ben Johny M, Xia XM, Lingle CJ. Regulatory γ1 subunits defy symmetry in functional modulation of BK channels. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9923-9928. doi: 10.1073/pnas.1804560115. Epub 2018 Sep 17. PubMed PMID: 30224470; PubMed Central PMCID: PMC6176617.
  5. Díaz-Franulic I, González-Pérez V, Moldenhauer H, Navarro-Quezada N, Naranjo D. Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8203-8208. doi: 10.1073/pnas.1806578115. Epub 2018 Jul 23. PubMed PMID: 30038023; PubMed Central PMCID: PMC6094148.
  6. Yang C, Gonzalez-Perez V, Mukaibo T, Melvin JE, Xia XM, Lingle CJ. Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3739-E3747. doi: 10.1073/pnas.1703081114. Epub 2017 Apr 17. PubMed PMID: 28416688; PubMed Central PMCID: PMC5422807.
  7. Martinez-Espinosa PL, Wu J, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. 2015 Nov 11;4. doi: 10.7554/eLife.10013. PubMed PMID: 26559620; PubMed Central PMCID: PMC4641468.
  8. Gonzalez-Perez V, Xia XM, Lingle CJ. Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating. Nat Commun. 2015 Sep 21;6:8341. doi: 10.1038/ncomms9341. PubMed PMID: 26388335; PubMed Central PMCID: PMC4578311.
  9. Martinez-Espinosa PL, Yang C, Gonzalez-Perez V, Xia XM, Lingle CJ. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol. 2014 Oct;144(4):275-95. doi: 10.1085/jgp.201411253. PubMed PMID: 25267913; PubMed Central PMCID: PMC4178941.
  10. Gonzalez-Perez V, Xia XM, Lingle CJ. Functional regulation of BK potassium channels by γ1 auxiliary subunits. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4868-73. doi: 10.1073/pnas.1322123111. Epub 2014 Mar 17. PubMed PMID: 24639523; PubMed Central PMCID: PMC3977294.
  11. Gonzalez-Perez V, Zeng XH, Henzler-Wildman K, Lingle CJ. Stereospecific binding of a disordered peptide segment mediates BK channel inactivation. Nature. 2012 May 3;485(7396):133-6. doi: 10.1038/nature10994. PubMed PMID: 22522931; PubMed Central PMCID: PMC3348258.
  12. González-Pérez V, Stack K, Boric K, Naranjo D. Reduced voltage sensitivity in a K+-channel voltage sensor by electric field remodeling. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5178-83. doi: 10.1073/pnas.1000963107. Epub 2010 Mar 1. PubMed PMID: 20194763; PubMed Central PMCID: PMC2841883.
  13. González-Pérez V, Neely A, Tapia C, González-Gutiérrez G, Contreras G, Orio P, Lagos V, Rojas G, Estévez T, Stack K, Naranjo D. Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium. J Gen Physiol. 2008 Dec;132(6):633-50. doi: 10.1085/jgp.200810057. PubMed PMID: 19029372; PubMed Central PMCID: PMC2585862.
  14. Oliva C, González V, Naranjo D. Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins. Biophys J. 2005 Aug;89(2):1009-19. doi: 10.1529/biophysj.105.060152. Epub 2005 May 27. PubMed PMID: 15923220; PubMed Central PMCID: PMC1366587.