Dr. Xia’s Publications

  1. Bond CT, Pessia M, Xia XM, Lagrutta A, Kavanaugh MP, Adelman JP. (1994) Cloning and expression of a family of inward rectifier potassium channels. Receptors & Channels 2(3):183-91.
  2. Lagrutta AA, Bond CT, Xia XM, Pessia M, Tucker S, Adelman JP: Inward rectifier potassium channels. (1996) Cloning, expression and structure-function studies. Japanese Heart Journal 37(5):651-60.
  3. Xia XM, Hirschberg B, Smolik S, Forte M, Adelman JP (1998) dSLIP1, a novel protein which interacts with large-conductance calcium-activated potassium channels. The Journal of Neuroscience 18(7):2360-2369
  4. Ishii TM, Zerr P, Xia XM, Bond CT, Maylie J, Adelman JP (1998) Site-directed mutagenesis. Methods in Enzymology 293:53-71
  5. Xia XM, Fakler B, Rivard A, Wayman G, Johnson-Pais T, Keen JE, Ishii T, Hirschberg B, Bond CT, Lutsenko S, Maylie, Adelman JP (1998) Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 395(6701): 503-7
  6. Xia XM, Ding JP, Lingle CJ. (1999) Molecular Basis for the Inactivation of Ca2+- and Voltage-Dependent BK Channels in Adrenal Chromaffin Cells and Rat Insulinoma Tumor Cells. The Journal of Neuroscience 19(13): 5255-5264
  7. Xia XM, Ding JP, Zeng XH, Duan KL, Lingle CJ (2000) Rectification and rapid activation at low Ca2+- of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. The Journal of Neuroscience 20(13): 4890-4903.
  8. Lingle CJ, Ding JP, Zeng XH, Xia XM (2001) A novel two-step inactivation mechanism produced by the N-terminus of the Beta3b accessory subunit of BK-type Ca2+-activated, voltage-activated K+ channels: possible separation of binding and blockade by an inactivation domain. The Journal of General Physiology 117(6): 583-606.
  9. Zeng XH, Ding JP, Xia XM, Lingle CJ (2001) Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. The Journal of General Physiology 117(6): 607-28.
  10. Wang YW, Ding JP, Xia XM, Lingle CJ (2002) Consequences of the stoichiometry of Slo1 (alpha) and auxiliary (beta) subunits on functional properties of BK-type Ca2+-activated K+ channels The Journal of Neuroscience 22(5): 1550-1561.
  11. Xia XM, Zeng XH, Lingle CJ (2002) Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418(6900): 880-4.
  12. Xia XM, Ding JP, Lingle CJ (2003) Inactivation of BK Channels by the NH2 Terminus of the Beta2 Auxilary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues. The Journal of General Physiology 121(2): 125-148.
  13. Zeng ZH, Xia XM, Lingle CJ (2003) Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. Nature Structural Biology 10(6): 448-454.
  14. Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo M (2003) Calmodulin Regulates Synaptic Plasticity in the Anterior Cingulate Cortex and Behavioral Responses: A Microelectroporation Study in Adult Rodents. The Journal of Neuroscience 23(23): 8402-8409.
  15. Xia XM, Zhang X, Lingle CJ (2004) Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. The Journal of Neuroscience 24(24): 5585-91.
  16. Zeng XH, Xia XM, Lingle CJ (2005) Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites. The Journal of General Physiology 125(3): 273-86.
  17. Benzinger GR, Xia XM, Lingle CJ (2006) Direct observation of a preinactivated, open state in BK channels with beta2 subunits. The Journal of General Physiology 127(2): 119:31.
  18. Zhang X, Zeng X, Xia XM, Lingle CJ (2006) pH-regulated Slo3 K+ channels: properties of unitary currents. The Journal of General Physiology 128(3):301-15.
  19. Zhang Z, Zhou Y, Ding JP, Xia XM, Lingle CJ (2006) A limited access compartment between the pore domain and cytosolic domain of the BK channel. The Journal of Neuroscience 26(46):11833-43.
  20. Zeng XH, Benzinger GR, Xia XM, Lingle CJ (2007) BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism. The Journal of Neuroscience 27(17):4707-15.
  21. Zeng XH, Xia XM, Lingle CJ (2008) Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. The Journal of General Physiology 132(1):115-29.
  22. Zhang Z, Zeng XH, Xia XM, Lingle CJ (2009) N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels. The Journal of General Physiology 133(3):263-82.
  23. Yang CT, Zeng XH, Xia XM, Lingle CJ (2009) Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS One 4(7):e6135.
  24. Tang QY, Zhang Z, Xia XM, Lingle CJ (2010) Block of mouse Slo1 and Slo3 K(+) channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin) 1(4):1-20.
  25. Zhou Y, Tang QY, Xia XM, Lingle CJ (2010) Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. The Journal of General Physiology 135(5):481-94.
  26. Chen B, Ge Q, Xia XM, Liu P, Wang SJ, Zhan H, Eipper BA, Wang ZW (2010) A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. The Journal of Neuroscience 30(49):16651-61.
  27. Zeng XH, Yang C, Kim ST, Lingle CJ, Xia XM (2011) Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. PNAS 108(14):5879-84.
  28. Zhou Y, Xia XM, Lingle CJ (2011) Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region. PNAS 108(29):12161-6.
  29. Yang C, Zeng XH, Zhou Y, Xia XM, Lingle CJ (2011) LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. PNAS 108(48):19419-24.
  30. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ (2013) Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. The Journal of General Physiology 142(3):305-13.
  31. Gonzalez-Perez V, Xia XM, Lingle CJ (2014) Functional regulation of BK potassium channels by γ1 auxiliary subunits. Proc Natl Acad Sci 111(13):4868-73.
  32. Brenker C, Zhou Y, Müller A, Echeverry FA, Trotschel C, Poetsch A, Xia XM, Bonigk W, Lingle CJ, Kaupp UB, Strünker T (2014) The Ca2+-activated K+ current of human sperm is mediated by Slo3. Elife 3:e01438.
  33. Martinez-Espinosa PL, Yang C, Gonzalez-Perez V, Xia XM, Lingle CJ (2014) Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol 144(4):275-95.
  34. Zeng XH, Yang C, Xia XM, Liu M, Lingle CJ (2015) SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proc Natl Acad Sci USA 112(8):2599-604.
  35. Zhou Y, Xia XM, Lingle CJ (2015) Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications. Proc Natl Acad Sci USA 112(16):5237-42.
  36. Gonzalez-Perez V, Xia XM, Lingle CJ (2015) Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating. Nat Commun. 6:8341.
  37. Martinez-Espinosa PL, Wu J, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ (2015) Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife 4. pii: e10013.
  38. Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K (2016) Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Anesthesiology. 124(5):1065-76.
  39. Yang C, Gonzalez-Perez V, Mukaibo T, Melvin JE, Xia XM, Lingle CJ (2017). Knockout of the LRRC26 subunit reveals a primary role of LRRC26- containing BK channels in secretory epithelial cells. Proc Natl Acad Sci USA 114(18): E3739-E3747.
  40. Zhou Y, Xia XM, Lingle CJ (2018). BK channel inhibition by strong extracellular acidification. Elife 7. pii: e38060.
  41. Gonzalez-Perez V, Ben Johny M, Xia XM, Lingle CJ (2018). Regulatory γ1 subunits defy symmetry in functional modulation of BK channels. Proc Natl Acad Sci USA 115(40): 9923-9928.
  42. Reijntjes DOJ, Lee JH, Park S, Schubert NMA, van Tuinen M, Vijayakumar S, Jones TA, Jones SM, Gratton MA, Xia XM, Yamoah EN, Pyott SJ (2019). Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. Sci Rep. 9(1):2573.
  43. Lingle CJ, Martinez-Espinosa PL, Yang-Hood A, Boero LE, Payne S, Persic D, V-Ghaffari B, Xiao M, Zhou Y, Xia XM, Pyott SJ, Rutherford MA (2019). LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells. Proc Natl Acad Sci USA 116(37):18397-18403.
  44. Zhou Y, Xia XM, Lingle CJ (2020). The functionally relevant site for paxilline inhibition of BK channels. Proc Natl Acad Sci USA 117(2):1021-1026.
  45. Gonzalez-Perez V, Martinez-Espinosa PL, Sala-Rabanal M, Bharadwaj N, Xia XM, Chen AC, Alvarado D, Gustafsson JK, Hu H, Ciorba MA, Lingle CJ (2021). Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice. Proc Natl Acad Sci USA 118(3):e2019149118.