2022
Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis
PLoS Pathogens. 2022 Jun 8; 18(6): 10.1371/journal.ppat.1010228
Bradley Hiller, Yongjun Yin, Yi-Chieh Perng, Ítalo de Araujo Castro, Lindsey Fox, Marissa Locke, Kristen Monte, Carolina López, David Ornitz, Deborah Lenschow
Interferon Alpha, but Not Interferon Beta, Acts Early To Control Chronic Chikungunya Virus Pathogenesis
Front Immunol. 2020; 11(606874): 1
J Virology. 2022 Jan 12; 96(1): 10.1128/JVI.01143-21
Marissa Locke, Lindsey Fox, Bria Dunlap, Alissa Young, Kristen Monte, Deborah Lenschow
En garde! The duel functions of MORC3
Cell Host Microbe. 2022 Jan 12; 30(1): 10.1016/j.chom.2021.12.017
Lindsey Fox, Deborah Lenschow
2021
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro
iScience. 2021 Oct 22; 24(10): 10.1016/j.isci.2021.103213
Caleb Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa Canadeo, Houda Harastani, Tamarand Darling, Adrianus Boon, Deborah Lenschow, Viraj Kulkarni, Jon Huibregtse
2020
Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease
Front Immunol. 2020; 11(606874): 10.3389/fimmu.2020.606874
Fox LE, Locke MC, Lenschow DJ
ISG15 connects autophagy and IFN-g-dependent control of Toxoplasma gondii infection in human cells
mBio. 2020 11:e00852-20.
Jaya Bhushan, Joshua Radke, Yi-Chieh Perng, Michael McAllaster, Deborah Lenschow, Herbert Virgin, and L. David Sibley
Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins
Cell Rep. 2020 Jun 16;31(11):107772.
Caleb D Swaim, Larissa A Canadeo , Kristen J Monte, Swati Khanna, Deborah J Lenschow, Jon M Huibregtse
2019
Distinct roles of interferon alpha and beta in controlling chikungunya virus replication and modulating neutrophil-mediated inflammation
J. Virol. 2019 Dec 12;94(1). pii: e00841-19.
Cook LE, Locke MC, Young AR, Monte KJ, Hedberg ML, Shimak RM, Sheehan KCF, Veis DJ, Diamond MS, and Lenschow DJ
Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA
PLoS Pathog. 2019 Aug 29;15(8):e1007993.
Young AR*, Locke MC*, Cook LE, Hiller BE, Zhang R, Hedberg ML, Monte KJ, Veis DJ, Diamond MS, Lenschow DJ
Highlight in
Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death
Am J Respir Cell Mol Biol. 2019 Feb;60(2):144-157.
Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP
2018
ISG15 in antiviral immunity and beyond
Nat Rev Microbiol. 2018 Jul;16(7):423-439.
Perng YC, Lenschow DJ
Lessons Learned From Chikungunya in the Americas
Arthritis Rheumatol. 2018 Apr;70(4):477-479.
Miner JJ, Lenschow DJ
2017
The microbial metabolite desaminotyrosine protects from influenza through type I interferon
Science. 2017 Aug 4;357(6350):498-502.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS
The impact of ISGylation during Mycobacterium tuberculosis infection in mice
Microbes Infect. 2017 Apr – May;19(4-5):249-258.
Kimmey JM, Campbell JA, Weiss LA, Monte KJ, Lenschow DJ, Stallings CL
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.
Lancet Infect Dis. 2017 Apr;17(4):e107-e117.
Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S
Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis
Sci Transl Med. 2017 Feb 1;9(375). pii: eaah3438.
Miner JJ*, Cook LE*, Hong JP, Smith AM, Richner JM, Shirmak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS
Highlight in 2017 Science Translational Medicine
2016
ISG15 deficiency and increased viral resistance in humans but not mice
Nat Commun. 2016 May 19;7:11496.
Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D
Replication-competent fluorescent-expressing influenza B virus
Virus Res. 2016 Feb 2;213:69-81.
Nogales A, Rodríguez-Sánchez I, Monte K, Lenschow DJ, Perez DR, Martínez-Sobrido L
2015
Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis
Arthritis Rheumatol. 2015 May;67(5):1214-1220.
Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82.
Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP
Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice
J Virol. 2015 Jan;89(1):337-49. doi: 10.1128/JVI.02110-14.
Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ
2014
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription
PLoS Pathog. 2014 Aug 28;10(8):e1004350.
Perng YC, Campbell JA, Lenschow DJ, Yu D
ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle
J Virol. 2014 Aug; 88(16):9277-86.
Rodriguez MR, Monte K, Thackray LB, Lenschow DJ
Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus
J Virol. 2014 Mar;88(5):2414-25.
Rohatgi A, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ
2013
The antiviral activities of ISG15
J Mol Biol. 2013 Dec 13;425(24):4995-5008.
Morales DJ, Lenschow DJ
Emerging roles for immunomodulatory functions of free ISG15
J Interferon Cytokine Res. 2013 Dec;33(12):728-38.
Campbell JA, Lenschow DJ
2012
Chikungunya virus-induced autophagy delays caspase-dependent cell death
J Exp Med. 2012 May 7;209(5):1029-47.
Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, Albert ML
2011
ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation
PLoS Pathog. 2011 Oct;7(10):e1002322.
Werneke SW, Schilte C, Rohatgi A, Monte KJ, Michault A, Arenzana-Seisdedos F, Vanlandingham DL, Higgs S, Fontanet A, Albert ML, Lenschow DJ
2010
Antiviral Properties of ISG15
Viruses. 2010 Oct;2(10):2154-68.
Lenschow DJ
2009
ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
J Virol. 2009 Feb;83(4):1602-10.
Giannakopoulos NV, Arutyunova E, Lai C, Lenschow DJ, Haas AL, Virgin HW
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection
J Virol. 2009 Jan;83(2):1147-51.
Lai C, Struckhoff JJ, Schneider J, Martinez-Sobrido L, Wolff T, García-Sastre A, Zhang DE, Lenschow DJ