2019

Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA

PLoS Pathog. 2019 Aug 29;15(8):e1007993.

Young AR*, Locke MC*, Cook LE, Hiller BE, Zhang R, Hedberg ML, Monte KJ, Veis DJ, Diamond MS, Lenschow DJ

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Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death

Am J Respir Cell Mol Biol. 2019 Feb;60(2):144-157.

Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP

2018

ISG15 in antiviral immunity and beyond

Nat Rev Microbiol. 2018 Jul;16(7):423-439.

Perng YC, Lenschow DJ

Lessons Learned From Chikungunya in the Americas

Arthritis Rheumatol. 2018 Apr;70(4):477-479.

Miner JJ, Lenschow DJ

2017

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Science. 2017 Aug 4;357(6350):498-502.

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS

The impact of ISGylation during Mycobacterium tuberculosis infection in mice

Microbes Infect. 2017 Apr – May;19(4-5):249-258.

Kimmey JM, Campbell JA, Weiss LA, Monte KJ, Lenschow DJ, Stallings CL

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

Lancet Infect Dis. 2017 Apr;17(4):e107-e117.

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S

Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah3438.

Miner JJ*, Cook LE*, Hong JP, Smith AM, Richner JM, Shirmak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS

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2016

ISG15 deficiency and increased viral resistance in humans but not mice

Nat Commun. 2016 May 19;7:11496.

Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D

Replication-competent fluorescent-expressing influenza B virus

Virus Res. 2016 Feb 2;213:69-81.

Nogales A, Rodríguez-Sánchez I, Monte K, Lenschow DJ, Perez DR, Martínez-Sobrido L

2015

Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis

Arthritis Rheumatol. 2015 May;67(5):1214-1220.

Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP

Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice

J Virol. 2015 Jan;89(1):337-49. doi: 10.1128/JVI.02110-14.

Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ

2014

Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription

PLoS Pathog. 2014 Aug 28;10(8):e1004350.

Perng YC, Campbell JA, Lenschow DJ, Yu D

ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle

J Virol. 2014 Aug; 88(16):9277-86.

Rodriguez MR, Monte K, Thackray LB, Lenschow DJ

Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus

J Virol. 2014 Mar;88(5):2414-25.

Rohatgi A, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ

2013

The antiviral activities of ISG15

J Mol Biol. 2013 Dec 13;425(24):4995-5008.

Morales DJ, Lenschow DJ

Emerging roles for immunomodulatory functions of free ISG15

J Interferon Cytokine Res. 2013 Dec;33(12):728-38.

Campbell JA, Lenschow DJ

2012

Chikungunya virus-induced autophagy delays caspase-dependent cell death

J Exp Med. 2012 May 7;209(5):1029-47.

Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, Albert ML

2011

ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation

PLoS Pathog. 2011 Oct;7(10):e1002322.

Werneke SW, Schilte C, Rohatgi A, Monte KJ, Michault A, Arenzana-Seisdedos F, Vanlandingham DL, Higgs S, Fontanet A, Albert ML, Lenschow DJ

2010

Antiviral Properties of ISG15

Viruses. 2010 Oct;2(10):2154-68.

Lenschow DJ

2009

ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus

J Virol. 2009 Feb;83(4):1602-10.

Giannakopoulos NV, Arutyunova E, Lai C, Lenschow DJ, Haas AL, Virgin HW

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection

J Virol. 2009 Jan;83(2):1147-51.

Lai C, Struckhoff JJ, Schneider J, Martinez-Sobrido L, Wolff T, García-Sastre A, Zhang DE, Lenschow DJ