2022
Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A. CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. Antioxidants (Basel). 2022 Dec 22;12(1). doi: 10.3390/antiox12010014. PubMed PMID: 36670876; PubMed Central PMCID: PMC9854525.
Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O, Hosomichi K, Nishiyama A, Yano S, Kirichok Y, Tan DS, Rosell R, Okimoto RA, Bivona TG. Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. J Clin Invest. 2022 Jul 1;132(13). doi: 10.1172/JCI145099. PubMed PMID: 35579943; PubMed Central PMCID: PMC9246391.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. PubMed PMID: 35614225; PubMed Central PMCID: PMC9646675.
Bertholet AM, Kirichok Y. Mitochondrial H(+) Leak and Thermogenesis. Annu Rev Physiol. 2022 Feb 10;84:381-407. doi: 10.1146/annurev-physiol-021119-034405. Epub 2021 Nov 10. Review. PubMed PMID: 34758268; PubMed Central PMCID: PMC8976115.
2021
Garg V, Suzuki J, Paranjpe I, Unsulangi T, Boyman L, Milescu LS, Lederer WJ, Kirichok Y. The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter. Elife. 2021 Aug 31;10. doi: 10.7554/eLife.69312. PubMed PMID: 34463251; PubMed Central PMCID: PMC8437439.
Liu B, Mundt N, Miller M, Clapham DE, Kirichok Y, Lishko PV. Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells. J Vis Exp. 2021 Feb 14;(168). doi: 10.3791/62049. PubMed PMID: 33645583.
2020
Bertholet AM, Kirichok Y. Patch-Clamp Analysis of the Mitochondrial H(+) Leak in Brown and Beige Fat. Front Physiol. 2020;11:326. doi: 10.3389/fphys.2020.00326. eCollection 2020. PubMed PMID: 32351404; PubMed Central PMCID: PMC7174661.
2019
Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG. Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep. 2019 Aug 27;28(9):2317-2330.e8. doi: 10.1016/j.celrep.2019.07.063. PubMed PMID: 31461649; PubMed Central PMCID: PMC6728083.
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24. PMID: 31341297; PMCID: PMC6662629.
Garg V, Kirichok YY. Patch-Clamp Analysis of the Mitochondrial Calcium Uniporter. Methods Mol Biol. 2019;1925:75-86. doi: 10.1007/978-1-4939-9018-4_7. PubMed PMID: 30674018.
2017
Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 4;25(4):811-822.e4. doi: 10.1016/j.cmet.2017.03.002. PubMed PMID: 28380374; PubMed Central PMCID: PMC5448977.
Bertholet AM, Kirichok Y. UCP1: A transporter for H(+) and fatty acid anions. Biochimie. 2017 Mar;134:28-34. doi: 10.1016/j.biochi.2016.10.013. Epub 2016 Oct 27. Review. PubMed PMID: 27984203; PubMed Central PMCID: PMC5461058.
2016
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11;166(4):841-854. doi: 10.1016/j.cell.2016.06.040. Epub 2016 Jul 21. PubMed PMID: 27453471; PubMed Central PMCID: PMC4985267.
Garg V, Kirichok Y. Keeping a lid on calcium uptake. Elife. 2016 Jun 3;5. doi: 10.7554/eLife.17293. PubMed PMID: 27258801; PubMed Central PMCID: PMC4892888.
Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29;352(6285):555-9. doi: 10.1126/science.aad6887. Epub 2016 Mar 17. PubMed PMID: 26989199; PubMed Central PMCID: PMC5373689.
2015
Lishko P, Kirichok Y. Signaling the differences between cilia. Elife. 2015 Dec 23;4. doi: 10.7554/eLife.12760. PubMed PMID: 26697758; PubMed Central PMCID: PMC4744198.
2014
Fieni F, Johnson DE, Hudmon A, Kirichok Y. Mitochondrial Ca2+ uniporter and CaMKII in heart. Nature. 2014 Sep 25;513(7519):E1-2. doi: 10.1038/nature13626. PubMed PMID: 25254480; PubMed Central PMCID: PMC4476531.
2013
Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV. Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6823-8. doi: 10.1073/pnas.1216588110. Epub 2013 Mar 25. PubMed PMID: 23530196; PubMed Central PMCID: PMC3637729.
Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013;525:59-83. doi: 10.1016/B978-0-12-397944-5.00004-3. PubMed PMID: 23522465; PubMed Central PMCID: PMC3909741.
2012
Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell. 2012 Oct 12;151(2):400-13. doi: 10.1016/j.cell.2012.09.010. PubMed PMID: 23063128; PubMed Central PMCID: PMC3782081.
Fieni F, Lee SB, Jan YN, Kirichok Y. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 2012;3:1317. doi: 10.1038/ncomms2325. PubMed PMID: 23271651; PubMed Central PMCID: PMC3818247.
2011
Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012;74:453-75. doi: 10.1146/annurev-physiol-020911-153258. Epub 2011 Oct 13. Review. PubMed PMID: 22017176; PubMed Central PMCID: PMC3914660.
Kirichok Y, Lishko PV. Rediscovering sperm ion channels with the patch-clamp technique. Mol Hum Reprod. 2011 Aug;17(8):478-99. doi: 10.1093/molehr/gar044. Epub 2011 Jun 4. Review. PubMed PMID: 21642646; PubMed Central PMCID: PMC3136206.
Lishko PV, Botchkina IL, Kirichok Y. Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. doi: 10.1038/nature09767. PubMed PMID: 21412339.
2010
Lishko PV, Kirichok Y. The role of Hv1 and CatSper channels in sperm activation. J Physiol. 2010 Dec 1;588(Pt 23):4667-72. doi: 10.1113/jphysiol.2010.194142. Epub 2010 Aug 2. PubMed PMID: 20679352; PubMed Central PMCID: PMC3010136.
Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell. 2010 Feb 5;140(3):327-37. doi: 10.1016/j.cell.2009.12.053. PubMed PMID: 20144758.
2004-2008
Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol. 2008;52(5-6):607-13. doi: 10.1387/ijdb.072554bn. Review. PubMed PMID: 18649274; PubMed Central PMCID: PMC4297656.
Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7688-92. doi: 10.1073/pnas.0702018104. Epub 2007 Apr 25. PubMed PMID: 17460039; PubMed Central PMCID: PMC1855916.
Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1219-23. doi: 10.1073/pnas.0610286104. Epub 2007 Jan 16. PubMed PMID: 17227845; PubMed Central PMCID: PMC1770895.
Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9;439(7077):737-40. doi: 10.1038/nature04417. PubMed PMID: 16467839.
Lozovaya N, Melnik S, Tsintsadze T, Grebenyuk S, Kirichok Y, Krishtal O. Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density. Brain Res. 2004 Jun 18;1011(2):195-205. doi: 10.1016/j.brainres.2004.03.023. PubMed PMID: 15157806.
Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22;427(6972):360-4. doi: 10.1038/nature02246. PubMed PMID: 14737170.
1998-2001
Krishtal O, Kirichok Y, Tsintsadze T, Lozovaya N, Loesel W, Arndts D. New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons. Neuropharmacology. 2001;40(2):233-41. doi: 10.1016/s0028-3908(00)00150-7. PubMed PMID: 11114402.
Kirichok Y, Boychuk YA, Kopanitsa MV, Tsintsadze TS, Lozovaya NA, Krishtal OA. Effect of mibefradil on synaptic transmission in hippocampus and voltage-dependent currents in CNS neurons. Neurophysiology. 2000; 32:16-20 (Russian).
Nikolaev AV, Kirichok Y, Ostrovskaya OI, Maletina II, Petko KI, Yagupolsky LM. Suppression of potassium A-current evoked by pinacidil and its derivatives in pyramidal hippocampal neurons. Neurophysiology. 1999; 31:232-235 (Russian).
Kirichok YV, Nikolaev AV, Krishtal OA. [K+]out accelerates inactivation of Shal-channels responsible for A-current in rat CA1 neurons. Neuroreport. 1998 Mar 9;9(4):625-9. doi: 10.1097/00001756-199803090-00012. PubMed PMID: 9559928.