Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell. 2012 Oct 12;151(2):400-13. doi: 10.1016/j.cell.2012.09.010. PubMed PMID: 23063128; PubMed Central PMCID: PMC3782081. Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting […]
Author: svu
Discoveries in Sperm Physiology and Male Fertility
Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9;439(7077):737-40. doi: 10.1038/nature04417. PubMed PMID: 16467839. Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell. 2010 Feb 5;140(3):327-37. doi: 10.1016/j.cell.2009.12.053. PubMed PMID: 20144758. Lishko PV, Botchkina IL, Kirichok Y. Progesterone activates the principal Ca2+ channel […]
Mitochondrial Calcium Uniporter (MCU)
Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22;427(6972):360-4. doi: 10.1038/nature02246. PubMed PMID: 14737170. Fieni F, Lee SB, Jan YN, Kirichok Y. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 2012;3:1317. doi: 10.1038/ncomms2325. PubMed PMID: 23271651; PubMed Central PMCID: PMC3818247. Fieni F, Johnson DE, Hudmon A, Kirichok Y. Mitochondrial Ca2+ uniporter […]
Methods to study mitochondria and sperm cells
Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22;427(6972):360-4. doi: 10.1038/nature02246. PubMed PMID: 14737170. Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell. 2012 Oct 12;151(2):400-13. doi: 10.1016/j.cell.2012.09.010. PubMed PMID: 23063128; PubMed Central PMCID: PMC3782081. Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an […]