Discoveries in Sperm Physiology and Male Fertility

Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9;439(7077):737-40. doi: 10.1038/nature04417. PubMed PMID: 16467839.

Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell. 2010 Feb 5;140(3):327-37. doi: 10.1016/j.cell.2009.12.053. PubMed PMID: 20144758.

Lishko PV, Botchkina IL, Kirichok Y. Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. doi: 10.1038/nature09767. PubMed PMID: 21412339.

Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV. Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6823-8. doi: 10.1073/pnas.1216588110. Epub 2013 Mar 25. PubMed PMID: 23530196; PubMed Central PMCID: PMC3637729.