Sheng Chen

Sheng is a graduate student in the lab. He graduated from Indiana University Bloomington in 2018, with B.S. in Biochemistry, B.S. in Neuroscience, and B.S in Psychology. He is originally from Shanghai, China. When he is not in the lab, he enjoys listening to music, watching movies and working out in the gym.


Lynch E.M., Pittman S., Daw J., Ikenaga C., Chen S., Dhavale D.D., Jackrel M.E., Ayala Y.M., Kotzbauer P., Ly C.V., Pestronk A., Lloyd T.E., and Weihl C.C. (2024). Seeding competent TDP-43 persists in human patient and mouse muscle. BioRxiv. link

Chen S., Puri A., Bell B., Fritsche J., Palacios H.H., Balch M., Sprunger M.L., Howard M.K., Ryan J.J., Haines J.N., Patti G.J., Davis A.A., and Jackrel M.E. (2024). HTRA1 disaggregates α-synuclein amyloid fibrils and coverts them into non-toxic and seeding incompetent species. Nat. Commun. 15: 2436. link

Shrimali, P.C., Chen S.*, Dreher R.D.*, Howard M.K.*, Buck J., Kim D., Rudra J.S.^, and M.E. Jackrel^ (2022). Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines. Biorxiv.
(*equal contributions, ^Co-corresponding author) pdf file link

Salazar, M.D., N.B. Zelt, R. Saldivar, C.P. Kuntz, S. Chen, W.D. Penn, R. Bonneau, J. Koehler Leman, and J.P. Schlebach. (2020). Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter. Biochemistry, 59 (13), 1367–1377.