Dr. Lake’s research focuses on multiscale structure-function relationships of musculoskeletal soft tissues and joints. He uses various imaging techniques (e.g., quantitative polarized light imaging, two-photo microscopy, x-ray microscopy) to quantify structural organization of tissues at various length scales and correlate with region-specific compositional and mechanical properties. His work seeks to understand fundamental principles that govern how soft tissues function […]
Dr. Zhang’s primary research interests include the development of multi-pixel x-ray source, tetrahedron x-ray imaging systems based on scanning x-ray sources. Almost all modern x-ray imaging systems including x-ray radiography, fluoroscopy, mammography and cone beam CT, to name only a few, utilize a single x-ray source and a 2D detector to acquire 2D images. Dr. Zhang’s […]
Dr. Tai’s team conceived and demonstrated the feasibility of the virtual-pinhole PET insert technology for improving the image resolution of existing human and animal PET scanners. This technology is currently being evaluated for whole-body cancer staging to improve the sensitivity of metastatic cancer detection. Additionally, Tai’s lab has developed several high resolution PET and multimodality […]
Dr. Shokeen’s lab has expertise in the development and evaluation of molecularly targeted small molecule and multi-functional macromolecular bio-conjugates for nuclear and optical imaging of cancer and cardiovascular diseases. Her group aspires to utilize the translational capabilities of quantitative imaging modalities (PET, SPECT, FMT and MRI) to bring the bench side discoveries into patient care. […]
Dr. Achilefu is interested in molecular optical imaging, the design and development of new molecular probes and nanomaterials, specific delivery of imaging agents and drugs to target cells or tissues, development of tissue-specific multi-modal imaging molecules, and tumor-specific photodynamic therapy agents. He is co-leader of the oncologic imaging program for the NCI-designated Siteman Cancer Center, […]
Dr. Hershey’s research is in the fields of neuroimaging and cognitive and clinical neuroscience. Her lab uses a range of neuroimaging, pharmacological and cognitive techniques to understand the impact of metabolic and neurodegenerative conditions on the brain, particularly during development. For example, her lab explores the neural underpinnings of cognitive and mood dysfunction in disorders […]
Dr. Taghert’s research focuses on (i) how peptidergic neurons differentiate and (ii) how neural circuits are controlled by the circadian clock to generate rhythmic behaviors. Both areas of study rely heavily on imaging methods, including standard epifluorescent and confocal microscopy, low light level imaging methods, and use of bioluminesent reporters to interrogate pacemaker neuron function […]
Dr. Bruchas’ lab is largely focused on optogenetic techniques and the neurobiology of stress and motivation, as it relates to neuromodulatory circuits, addiction, and GPCR signaling. In particular, a strong theme of the lab is the use of in vivo optogenetics to dissect affective behavioral circuits in reward, aversion, and anxiety (Science, Cell, Neuron, Nature Communications). […]
Dr. Peterson pioneered the use of brain imaging (PET and fMRI) to identify brain regions that contribute to attention, learning, memory and language. He also investigates the effects of disease and brain damage on these cognitive processes. Currently, he has two main areas of interest. The first focus is the development of neural mechanisms underlying […]
Dr. Nehorai’s research deals with analysis of space-time data in a number of biomedical areas. In biomedicine, he is developing methods for locating electrical sources in the brain using arrays of electrodes (EEG) or magnetometers (MEG) placed around the head. His solutions are important for clinical applications such as finding origins of seizures, or in […]
