Dr. Culver’s Lab develops neurophotonic technology for mapping brain function in humans and animal models. With the goal of producing high-performance portable brain imaging in humans, his group has been developing a series of innovations for diffuse optical tomography (DOT) instrumentation and algorithms. Recently they presented the first DOT system capable of mapping distributed brain function and networks (Nature Photonics). Applied projects include mapping brain function in infants in the neonatal ICU, and in stroke patients in the Adult ICU. In parallel with human imaging efforts, the Culver lab is also developing mouse equivalent measurements of functional connectivity using optical intrinsic signal imaging (fcOIS) – so as to link human fcMRI with mouse models of disease (e.g., amyloid-beta models of Alzheimer’s, stroke, brain tumors, autism). Recently, to work with faster physiological signals, they have extend fcOIS to mice with genetically encoded calcium indicators and are exploring transitions between awake/sleep and anesthesia.