Hooi Ling Kee

Program Years: 2007

Mentors:

Primary: Dewey Holton

Secondary: Joseph P Culver 

Graduate Thesis Title: 

Publications: 

L. Kee, C. Kirmaier, Q. Tang, J. R. Diers, C. Muthiah, M. Taniguchi, J. K Laha, M. Ptaszek, J. L. Lindsey, D. F. Bocian, and D. Holten Effects of Substituents on Synthetic Analogues of Chlorophylls. Part 1: Synthesis, Vibrational Properties and Excited-State Decay Characteristics. Photochem. Photobiol. 2007 83, 1125-43.

L. Kee, C. Kirmaier, Q. Tang, J. R. Diers, C. Muthiah, M. Taniguchi, J. K Laha, M. Ptaszek, J. S. Lindsey, D. F. Bocian, and D. Holten Effects of Substituents on Synthetic Analogues of Chlorophylls. Part 2: Redox Properties, Optical Spectra and Electronic Structure. Photochem. Photobiol. 2007, 83, 1125-1143.

L. Kee, R. Nothdurft, C. Muthiah, J. R. Diers, D. Fan, M. Ptaszek, D. F. Bocian, J. S. Lindsey, J. P. Culver, and D. Holten Examination of Chlorin-Bacteriochlorin Energy-Transfer Dyads as Prototypes for Near-Infrared Molecular Imaging Probes. Photochem. Photobiol. 2008, 84, 1061-1072.

E. Borbas, H. L. Kee, D. Holten and J. S. Lindsey. A Compact Water-Soluble Porphyrin Bearing an Iodoacetamido Bioconjugatable Site, Org. Biomol. Chem. 2008,6, 187 – 194.

Muthiah, H. L. Kee, J. R. Diers, D. Fan, M. Ptaszek, D. F. Bocian, Holten, and J. S. Lindsey. Synthesis and Excited-State Photodynamics of a Chlorin–Bacteriochlorin Dyad: Through- Space Versus Through-Bond Energy Transfer In Tetrapyrrole Arrays. Photochem. Photobiol. 2008,84, 786-801

E. Borbas, V. Chandrashaker, C. Muthiah, H. L. Kee, D. Holten, J.Lindsey. Design, Synthesis, and Photophysical Characterization of Water-Soluble Chlorins. J. Org. Chem. 2008,73, 3145-3158.

Taniguchi,D. L. Cramer,A. D. Bhise,H. L. Kee,D. F. Bocian, D. Holten, and J. S. Lindsey. Accessing the Near-Infrared Spectral Region with Stable, Synthetic, Wavelength-Tunable Bacteriochlorins, New J. Chem. 2008, 32, 893-1080.

L. Kee, R. Nothdurft, C. Muthiah, J. R. Diers, D. Fan, M. Ptaszek, D. F. Bocian, J. S. Lindsey, J. P. Culver, and D. Holten. Examination of Chlorin-Bacteriochlorin Energy-Transfer Dyads as Prototypes for Near-Infrared Molecular Imaging Probes. Photochem. Photobiol. 2008, 84, 1061-1072

L. Kee, J. Bhaumik, J. R. Diers, P. Mroz, M. R. Hamblin, D. F. Bocian, J. S. Lindsey, and D. Holten. Photophysical Characterization of Imidazolium-Substituted Pd(II), In(III), and Zn(II) Porphyrins as Photosensitizers for Photodynamic Therapy. Journal of Photochem. Photobiol. A: Chemistry 2008, 200, 346-355.

Mroz, J. Bhaumik, Z. Aly, Z. Kamal, L. Khalid, H. L. Kee, D. F. Bocian, D. Holten, J. S. Lindsey, M. R. Hamblin. Imidazole Metalloporphyrins as Photosensitizers for Photodynamic Therapy: Role of Molecular Charge, Central Metal and Hydroxyl Radical Production. Cancer Lett. 2009, 282, 63-76.

L. Kee, J. R. Diers, M. Ptaszek, C. Muthiah, D. Fan, J. S. Lindsey, D. F. Bocian, and D. Holten. ChlorinBacteriochlorin Energy- Transfer Dyads as Prototypes for Near-infrared Molecular Imaging Probes: Controlling Charge-Transfer and Fluorescence Properties in Polar Media. Photochem Photobiol. 2009 85, 909-920

Mass, M. Ptaszek, M. Taniguchi, J. R. Diers, H. L. Kee, D. F. Bocian, D. Holten, and J. S. Lindsey J. Synthesis and Photochemical Properties of 12-Substituted versus 13- Substituted Chlorins, Org. Chem. 2009, 74, 5276-5289.

Mroz, Y.-Y. Huang, S. Janjua, T. Zhiyentayev, A. Szokalska, A-P Nifli, M. Sherwood, C. Ruzié, K. E. Borbas, D. Fan, M. Krayer, T. Balasubramanian, E. Yang, H. L. Kee, C. Kirmaier, J. R. Diers, D. F. Bocian, D. Holten, J. S. Lindsey, and M. R. Hamblin. New stable synthetic bacteriochlorins for photodynamic therapy of melanoma. Proc of SPIE (Photodynamic Therapy: Back to the Future) 2009, 7380, 73802S-3802S-14.

Ptaszek, H. L. Kee, C. Muthiah, R. Nothdurft, W. Akers, S. Achilefu, J. P. Culver, and D. Holten. Near-infrared molecular imaging probes based on chlorin-bacteriochlorin dyads. Proc of SPIE 2010, 7565, 75760E1-11.

Mroz, Y.-Y. Huang, S. Janjua, T. Zhiyentayev, A. Szokalska, A-P Nifli, M. Sherwood, C. Ruziée, K. E. Borbas, D. Fan, M. Krayer, T. Balasubramanian, E. Yang, H. L. Kee, C. Kirmaier, J. R. Diers, D.Bocian, D. Holten, J. S. Lindsey, and M. R. Hamblin. Stable Synthetic Bacteriochlorins Overcome the Resistance of Melanoma to Photodynamic Therapy. FASEB J. 2010, 24, 3610-3170.

Huang, Y. Y., Mroz, P., Zhiyentayev, T., Sharma, S. K., Balasubramanian, T., Ruzié, C., … & Kee, H. L. (2010). In vitro photodynamic therapy and quantitative structure− activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers. Journal of medicinal chemistry, 53(10), 4018-4027.

Huang, Y.-Y. Huang, G. P. Tegos, T. Zhiyentayev, S. K Sharma, T. Balasubramian, M. Krayer, C. Ruzié,  E. Yang, H. L. Kee, C. Kirmaier, J. R. Diers, D. F. Bocian, D. Holten, J. S. Lindsey, and M. R. Hamblin. Stable Synthetic Cationic Bacteriochlorins as Antimicrobial Photosensitizers.  Antimicrobial Agents and Chemotherapy (AAC) 2010, 54, 3834-3841.