Christina Ambrosi

Program Years: 2007-2008

Mentors:

Primary: Igor Efimov

Secondary: Rollins

Graduate Thesis Title: Atrial Arrhythmogenic Substrates: The Role of Structure and Molecular Remodeling

Publications: 

Ambrosi CM, Moazami N, Rollins AM, Efimov IR.  Virtual histology of the human heart using optical coherence tomography.  J Biomed Opt. 2009 Sep-Oct;14(5):054002.  PMC2774972

Ambrosi CM, Ripplinger CM, Efimov IR, Fedorov VV. Termination of sustained atrial flutter and fibrillation using low-voltage multiple- shock therapy. Heart Rhythm. 2011 8(1):101-108.

Ambrosi, C. M., Yamada, K. A., Nerbonne, J. M., & Efimov, I. R. (2013). Gender differences in electrophysiological gene expression in failing and non-failing human hearts. PLoS One, 8(1), e54635.

Ambrosi, C. M., Fedorov, V. V., Schuessler, R. B., Rollins, A. M., & Efimov, I. R. (2012). Quantification of fiber orientation in the canine atrial pacemaker complex using optical coherence tomography. Journal of biomedical optics, 17(7), 071309-071309.

Ambrosi, C. M., Klimas, A., Yu, J., & Entcheva, E. (2014). Cardiac applications of optogenetics. Progress in biophysics and molecular biology, 115(2), 294-304.

Ambrosi, C. M., Ripplinger, C. M., Efimov, I. R., & Fedorov, V. V. (2009). Multiple Low-Energy Shock Therapy Terminates Atrial Flutter and Fibrillation More Effectively than ATP. Heart Rhythm, 6(11), 1686-1687.

Ambrosi, C. M., Fedorov, V. V., Schuessler, R. B., Rollins, A. M., & Efimov, I. R. (2012). Special Section on Selected Topics in Biophotonics: Optical Coherence Tomography and Medical Imaging Using Diffuse Optics: Quantification of fiber orientation in the canine atrial pacemaker complex using optical coherence tomography. Journal of Biomedical Optics, 17(7).

Efimov IR, Fedorov VV, Glukhov A, Lou Q, Ambrosi C, Janks D, Hucker WJ, Kurian T, Schuessler RB, Moazami N.  Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine. Conf Proc IEEE Eng Med Biol Soc. 2010, 1:5177-5180.

Fedorov VV, Schuessler RB, Hemphill M, Ambrosi CM, Chang R, Voloshina AS, Brown K, Hucker WJ, Efimov IR. Structural and functional evidence for discrete exit pathways that connect the canine sinoatrial node and atria.  Circ Res. 2009 104:915-923.PMC2740656

Fedorov, V. V., Glukhov, A. V., Ambrosi, C. M., Kostecki, G., Chang, R., Janks, D., … & Efimov, I. R. (2011). Effects of K ATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. Journal of molecular and cellular cardiology, 51(2), 215-225.

Fedorov, V.V., Ambrosi, C.M., Kostecki, G., Hucker, W.J., Glukhov, A.V., Wuskell, J.P., Loew, L.M., Moazami, N. and Efimov, I.R., 2011. Anatomic localization and autonomic modulation of atrioventricular junctional rhythm in failing human hearts. Circulation: Arrhythmia and Electrophysiology, 4(4), pp.515-525.

Fedorov, V. V., Ambrosi, C. M., Hucker, W. J., Glukhov, A. V., Foyil, K. V., Wuskell, J., … & Efimov, I. R. (2008). Human AV junctional pacemaker shift due to cholinergic and adrenergic stimulations: optical imaging with a novel long wavelength voltage-sensitive dye. Circulation, 118(18 Supplement), S_520.

Kurian T, Ambrosi C, Hucker W, Fedorov VV, Efimov IR.  Anatomy and Electrophysiology of the Human AV Node.  Pacing Clin Electrophysiol. 33(6):754-762.  PMC2889145

Lou, Q., Janks, D. L., Holzem, K. M., Lang, D., Onal, B., Ambrosi, C. M., … & Efimov, I. R. (2012). Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling. American Journal of Physiology-Heart and Circulatory Physiology, 303(12), H1426-H1434.