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- Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin,Yun Ju Sung, and Carlos Cruchaga. “Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s disease” medRxiv preprint 2023 – DOI: 10.1101/2023.01.05.23284241
- Jara Cárcel-Márquez , Elena Muiño , Cristina Gallego-Fabrega , Natalia Cullell , Miquel Lledós , Laia Llucià-Carol , Tomás Sobrino , Francisco Campos , José Castillo , Marimar Freijo , Juan Francisco Arenillas , Victor Obach , José Álvarez-Sabín , Carlos A Molina , Marc Ribó , Jordi Jiménez-Conde , Jaume Roquer , Lucia Muñoz-Narbona , Elena Lopez-Cancio , Mònica Millán , Rosa Diaz-Navarro , Cristòfol Vives-Bauza , Gemma Serrano-Heras , Tomás Segura , Laura Ibañez , Laura Heitsch , Pilar Delgado , Rajat Dhar , Jerzy Krupinski , Raquel Delgado-Mederos , Luis Prats-Sánchez , Pol Camps-Renom , Natalia Blay , Lauro Sumoy , Rafael de Cid , Joan Montaner , Carlos Cruchaga , Jin-Moo Lee , Joan Martí-Fàbregas , and Israel Férnandez-Cadenas. “A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype” Frontiers in Cardiovascular Medicine 2022; 9:940696 – DOI: 10.3389/fcvm.2022.940696
- Lynn Bitar, Timo Uphaus, Carine Thalman, Muthuraman Muthuraman, Luzia Gyr, Haichao Ji, Micaela Domingues, Heiko Endle, Sergiu Groppa, Falk Steffen, Nabin Koirala, Wei Fan, Laura Ibanez, Laura Heitsch, Carlos Cruchaga, Jin-Moo Lee, Florian Kloss, Stefan Bittner, Robert Nitsch, Frauke Zipp, and Johannes Vogt. “Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke” Science Translational Medicine 2022; 14(641) – DOI: 10.1126/scitranslmed.abk0135
- Hsiang-Han Chen, Abdallah Eteleeb, Ciyang Wang, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, Joanne Norton, Fengxian Wang, Curtis Ebl, John C. Morris, Richard J. Perrin, Randall J. Bateman, Eric McDade, Chengjie Xiong, Alison Goate, Martin Farlow, Jasmeer Chhatwal, Peter R. Schofield, Helena Chui, Oscar Harari, Carlos Cruchaga, Laura Ibanez, and Dominantly Inherited Alzheimer Network. “Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease” Acta Neuropathologica Communications 2022; 10(29) – DOI: 10.1186/s40478-022-01328-5-5
- Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H G Farias, Jorge L Del Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia Ling Phuah, Robin Lemmens, Alessandro A Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, Gemma Serrano-Heras, Jong Won Chung, Jaume Roquer, Carol Soriano-Tarraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Antoni Davalos, Elena Lopez-Cancio, Lucia Muñoz, Turgut Tatlisumak, Carlos Molina, Marc Ribo, Alejandro Bustamante, Tomas Sobrino, Jose Castillo-Sanchez, Francisco Campos, Emilio Rodriguez-Castro, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, Christina Herbosa, Andria L Ford, Alonso Gutierrez-Romero, Rodrigo Uribe-Pacheco, Antonio Arauz, Iscia Lopes-Cendes, Theodore Lowenkopf, Miguel A Barboza, Hajar Amini, Boryana Stamova, Bradley P Ander, Frank R Sharp, Gyeong Moon Kim, Oh Young Bang, Jordi Jimenez-Conde, Agnieszka Slowik, Daniel Stribian, Ellen A Tsai, Linda C Burkly, Joan Montaner, Israel Fernandez-Cadenas, Jin Moo Lee, and Carlos Cruchaga. “Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke” Brain 2022; 145(7):2394–2406 – DOI: 10.1093/brain/awac080
- Laura Ibanez, Carlos Cruchaga, Maria Victoria Fernandez. “Advances in Genetic and Molecular Understanding of Alzheimer’s Disease” Genes 2021;12(8):1247 – DOI: 10.3390/genes12081247
- Laura Heitsch, Laura Ibanez, Caty Carrera, Michael Binkley, Daniel Strbian, Turgut Tatlisumak, Alejandro Bustamante, Marc Ribo, Carlos Molina, Antoni Davalos, Elena Lopez-Cancio, Luci¬a Muñoz-Narbona, Carolina Soriano-Tárraga, Eva Giralt Steinhauer, Victor Obach, Agnieszka Slowik, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Tomas Sobrino, Jose Castillo, Francisco Campos, Emilio Rodríguez-Castro, Susana Arias, Tomas Segura, Gemma Serrano-Heras, Cristofol Vives-Bauza, Rosa Diaz-Navarro, Silvia Tur, Carmen Jiménez, Joan Martí-Fàbregas, Raquel Delgado-Mederos, Juan Arenillas, Jerzy Krupinski, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Carcel-Marquez, Francisco Moniche, Juan Cabezas, Andria Ford, Rajat Dhar, Jaume Roquer, Pooja Khatri, Jordi Jiménez-Conde, Israel Fernandez-Cadenas, Joan Montaner, Jonathan Rosand, Carlos Cruchaga, and Jin-Moo Lee. “Early change in NIH stroke scale after ischemic stroke captures brain injury mechanisms and predicts 90-day outcome” Stroke 2021; 52(1):132-141 – DOI: 10.1161/STROKEAHA.119.028687
- Chengran Yang, Fabiana H. G. Farias, Laura Ibanez, Adam Suhy, Brooke Sadler, Maria Victoria Fernandez, Fengxian Wang, Joseph L. Bradley, Brett Eiffert, Jorge A. Bahena, John P. Budde, Zeran Li, Umber Dube, Yun Ju Sung, Kathie A. Mihindukulasuriya, John C. Morris, Anne M. Fagan, Richard J. Perrin, Bruno A. Benitez, Herve Rhinn, Oscar Harari & Carlos Cruchaga. “Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders” Nature Neurosciences 2021 – DOI: 10.1038/s41593-021-00886-6
- Laura Ibanez, Jorge A Bahena, Chengran Yang, Umber Dube, Fabiana G H Farias, John P Budde, Kristy Bergmann, Carol Brenner-Webster, John C Morris, Richard J Perrin, Niger Cairns, John O’Donnell, Ignacio Alvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A Davis, Pau Pastor, Paul Kotzbauer, Meghan C Campbell, Joel S Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga, Bruno A. Benitez. “Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease” Acta Neuropathologica Communications 2020; 8(1):196 – DOI: 10.1186/s40478-020-01072-8
- Laura Ibanez, Laura Heitsch, Umber Dube, Fabiana HG Farias, John Budde, Kristy Bergmann, Rich Davenport, Joseph Bradley, Caty Carrera, Janne Kinnunen, Hanne Sallinen, Daniel Strbian, Agnieszka Slowik, Israel Fernandez-Cadenas, Joan Montaner, Jin-Moo Lee, Carlos Cruchaga, International Stroke Genetics Consortium and the MEGASTROKE Consortium. “Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors” Stroke 2019;50(6):1339-1345 – DOI: 10.1161/STROKEAHA.118.023097
- Laura Ibanez, Fabiana HG Farias, Umber Dube, Kathie A Mihindukulasuriya, Oscar Harari. “Polygenic risk scores in neurodegenerative diseases: A review” Current Genetic Medicine Reports 2019;7(1):22-29 – DOI: 10.1007/s40142-019-0158-0
- Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A Benitez, Celeste M Karch, Laura Piccio, Carlos Cruchaga. “The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk” Science Translational Medicine 2019;14;11(505) – DOI: 10.1126/scitranslmed.aau2291
- Umber Dube, Jorge L Del-Aguila, Zeran Li, John P Budde, Shan Jiang, Simon Hsu, Laura Ibanez, Maria Victoria Fernandez, Fabiana Farias, Joanne Norton, Jen Gentsch, Fengxian Wang, Stephen Salloway, Colin L Masters, Jae-Hong Lee, Neill R Graff-Radford, Jasmeer P Chhatwal, Randall J Bateman, John C Morris, Celeste M Karch, Oscar Harari, Carlos Cruchaga. “An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations” Nature Neuroscience 2019;22(11):1903-1912 – DOI: 10.1038/s41593-019-0501-5
- Laura Ibanez, Umber Dube, Albert A Davis, Maria V Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Sara Ortega-Cubero, Pau Pastor, Joel S Perlmutter, Carlos Cruchaga, Bruno A Benitez. “Pleiotropic effects of variants in dementia genes in Parkinson disease” Frontires in Neuroscience 2018;12:230 – DOI: 10.3389/fnins.2018.00230
- Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L Del-Aguila, Albert A Davis, Joel S Perlmutter, Oscar Harari, Bruno A Benitez, Carlos Cruchaga. “Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels” BMC Neurology 2017;17(1):198 – DOI: 10.1186/s12883-017-0978-z
- Laura Ibanez, Umber Dube, John Budde, Kathleen Black, Alexandra Medvedeva, Albert A Davis, Joel S Perlmutter, Bruno A Benitez, Carlos Cruchaga. “TMEM230 in Parkinson’s disease” Neurobiology of Aging 2017;56:212.e1-212.e3 – DOI: 10.1016/j.neurobiolaging.2017.03.014
- Laura Ibáñez, Pablo Sebastián Velli, Roser Font, Angeles Jaén, Josep Royo, Daniel Irigoyen, Mireia Cairó, Alejandro De la Sierra, María Jesús Arranz, David Gallardo, David Dalmau. “HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population” PLoS One 2014;10;9(11):e112279 – DOI: 10.1371/journal.pone.0112279