Pre-prints

We are committed to accessible science and understand the value of pre-prints. The following are a selection of our current manuscripts under review.


Systematic characterization of brain cellular crosstalk signaling networks in Alzheimer’s disease reveals a novel role for SEMA6D in TREM2-dependent microglial activation

Ricardo D’Oliveira Albanus, Gina M. Finan, Logan Brase, Shuo Chen, Qi Guo, Abhirami Kannan, Mariana Acquarone, Shih-Feng You, Brenna C Novotny, Patricia M Ribeiro Pereira, John C Morris, Randall J Bateman, Eric McDade, Carlos Cruchaga, Jasmeer P Chhatwal, Dominantly Inherited Alzheimer Network (DIAN), Emily E Mace, Bruno A Benitez, Laura Piccio, Greg T Sutherland, Qin Ma, Hongjun Fu, Celeste M Karch, Oscar Harari, Tae-Wan Kim

bioRxiv 2022.11.11.516215; doi: https://doi.org/10.1101/2022.11.11.516215


Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaques

Matthew J. Rosene, Simon Hsu, Shih Feng You, Logan Brase, Anthony Verbeck, Rita Martinez, Clare E. Wallace, Zeran Li, Ping Yan, Nina M. Dräger, Sydney M. Sattler, Abhirami K Iyer, Shannon L Macauley, David M. Holtzman, Bruno A. Benitez, Martin Kampmann, Carlos Cruchaga, Oscar Harari, John R. Cirrito, Jin-Moo Lee, Alison M. Goate, Celeste M. Karch
medRxiv 2022.01.31.22270175; doi: https://doi.org/10.1101/2022.01.31.22270175


Cross-omics integration shows cortex-wide synaptic dysfunction at later stages of Alzheimer disease

Abdallah M. Eteleeb, Brenna C. Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A. Davis, John C. Morris, Celeste M. Karch, Richard J. Perrin, Bruno A. Benitez, Oscar Harari

https://www.medrxiv.org/content/10.1101/2022.12.10.22283295v1.full-text