EtpA complexed to Fab 1C08
Plos Pathog 2024
Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization Sheikh A, Ganguli D, Vickers TJ, Singer BB, Foulke-Abel J, Akhtar M, Khatoon N, Setu B, Basu S, Harro C, Maier N, Beatty WL, Chakraborty S, Bhuiyan TR, Qadri F, Donowitz M, Fleckenstein JM. Proc Natl Acad Sci USA. 2024. 128(3) e2410679121
Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin Berndsen ZT, Akhtar M, Thapa M, Vickers TJ, Schmitz A, Torres JL, Baboo S, Kumar P, Khatoon N, Sheikh A, Hamrick M, Diedrich JK, Martinez-Bartolome S, Garrett PT, Yates JR, Turner JS, Laird RM, Poly F, Porter CK, Coops J, Ellebedy AH, Ward AB, Fleckenstein JM. Plos Pathog. 2024 20(9):e1012241.
Enterotoxigenic Escherichia coli Degrades the Host MUC2 Mucin Barrier To Facilitate Critical Pathogen-Enterocyte Interactions in Human Small Intestine. Sheikh A, Wangdi T, Vickers TJ, Aaron B, Palmer M, Miller MJ, Kim S, Herring C, Simoes R, Crainic JA, Gildersleeve JC, van der Post S, Hansson GC, Fleckenstein JM.Infect Immun. 2022 Feb 17;90(2):e0057221. doi: 10.1128/IAI.00572-21. Epub 2021 Nov 22.
Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia. Sheikh A, Tumala B, Vickers TJ, Martin JC, Rosa BA, Sabui S, Basu S, Simoes RD, Mitreva M, Storer C, Tyksen E, Head RD, Beatty W, Said HM, Fleckenstein JM. Nature Communications (2022)12:6886.
Changing the locks on intestinal signaling.Fleckenstein JM, Bitoun JP.Cell Host Microbe. 2021 Sep 8;29(9):1335-1337. doi: 10.1016/j.chom.2021.08.005.
Emerging Themes in the Molecular Pathogenesis of Enterotoxigenic Escherichia coli.Fleckenstein JM, Sheikh A.J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S813-S820. doi: 10.1093/infdis/jiab359.
Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli.Kuhlmann FM, Laine RO, Afrin S, Nakajima R, Akhtar M, Vickers T, Parker K, Nizam NN, Grigura V, Goss CW, Felgner PL, Rasko DA, Qadri F, Fleckenstein JM.Infect Immun. 2021 Apr 16;89(5):e00041-21. doi: 10.1128/IAI.00041-21. Print 2021 Apr 16.
CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli.Sheikh A, Tumala B, Vickers TJ, Alvarado D, Ciorba MA, Bhuiyan TR, Qadri F, Singer BB, Fleckenstein JM.Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29055-29062. doi: 10.1073/pnas.2012480117. Epub 2020 Nov 2.
Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection.Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM.NPJ Vaccines. 2019 Aug 28;4:37. doi: 10.1038/s41541-019-0131-7. eCollection 2019.
Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.J Clin Invest. 2018 Aug 1;128(8):3298-3311. doi: 10.1172/JCI97659. Epub 2018 Jun 25.
Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development.Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM.J Infect Dis. 2018 Sep 22;218(9):1436-1446. doi: 10.1093/infdis/jiy312.
Adhesin degradation accelerates delivery of heat-labile toxin by enterotoxigenic Escherichia coli.Roy K, Kansal R, Bartels SR, Hamilton DJ, Shaaban S, Fleckenstein JM.J Biol Chem. 2011 Aug 26;286(34):29771-9. doi: 10.1074/jbc.M111.251546. Epub 2011 Jul 8.
Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells.Roy K, Hilliard GM, Hamilton DJ, Luo J, Ostmann MM, Fleckenstein JM.Nature. 2009 Jan 29;457(7229):594-8. doi: 10.1038/nature07568. Epub 2008 Dec 7.