This project focused monitoring for signs of organ failure and rejection in Type I diabetic patients who have received a simultaneous pancreas-kidney (SPK) transplant from both living and deceased donors. The goal of our project is to monitor signs of organ failure and rejection in patients who have received transplants using an implantable, wireless sensor that will detect specific factors such as blood oxygenation levels and inflammatory factors that correspond to organ failure or rejection. The patient would need a minimally impactful sensor that could effectively monitor their organ following transplant. The clinician would want to know specific indicators for organ rejection or failure and potentially provide immediate mitigation of the rejection while notifying the clinician of these signs, which would inform potential treatment plans. The project would be considered complete when the implantable sensor effectively and efficiently detects the relevant indicators for organ failure or rejection in rat models.