2018 Lab Members

Elgin lab, fall 2018. Back row: Ben French, Michael Grupe, Jo Wuller, Jacob Cantrell; front row, Alice Herrmann, Gary Huang, Amy Kwan, Wilson Leung, Elena Gracheva, Sophia Bieser, Sarah Elgin. Not pictured: Chris Shaffer, Kendra Woodruff, Ariel Feng, Mikayla Johnson, Caelan Miller.

Current Lab Members

Sarah C.R. Elgin

Professor of Biology

Howard Hughes Medical Institute Professor
Viktor Hamburger Professor Emerita in Arts & Sciences

Ph.D. Biochemistry, California Institute of Technology
Chromatin structure and gene expression in Drosophila; chromosomal proteins; heterochromatin/euchromatin; dot chromosome; RNAi in heterochromatin formation.

Christopher Shaffer

Ph.D. Genetics, Cornell University
Identification and characterization of HP2, a chromosomal protein that interacts with HP1; dot chromosome.

Elena Gracheva

Ph.D. Molecular Genetics, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Medros, St. Louis
Designing a genetic screen for enhancers and suppressors of GAGA factor activity; role of RNAi in heterochromatin formation; VIG2.

Wilson Leung

B.A. in Biology, Washington University.
Computational analysis of the dot chromosome of D. melanogaster and D. virilis.

Lab Technicians

Jo Wuller

Technician

B.S. Economics, St. Louis University
Organization of chromosome four; Drosophila stock-keeper.

Undergraduate Students

Jacob Cantrell

Undergraduate Student

Ben French

Undergraduate Student

Kendra Woodruff

Undergraduate Student

Mikayla Johnson

Undergraduate Student

Amy Kwan

Undergraduate Student

Alice Herrmann

Undergraduate Student

Ariel Feng

Undergraduate Student

Caelan Miller

Undergraduate Student

The Elgin Lab 2010

The Elgin Lab, friends and family, June 2004

The Elgin Lab, friends and family, summer 1998

Postdoctoral Fellows and Research Scientists (current or last known position)

Ann A. Ribolini

1976-1978 (NIH Fellowship); staff member, Biogen.

Kashiyar Javaherian

1979-1980; staff member, Repligen.

Gary Howard

1978-1981; Senior Scientific Editor, J. David Gladstone Institutes, UCSF.

Ky Lowenhaupt

1979-1983 (NIH Fellowship); Senior Research Associate with A. Rich, M.I.T.

Gerhard Fleischmann

1980-1983; teacher and environmental advisor, Künzell, Germany.

Iain L. Cartwright

1979-1985; Associate Professor of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine.

T.C. James

1982-1986; Research Associate, Microbiology, Trinity College, Dublin, Eire.

James Flick

1983-1986; Section Director, Dept Laboratory Medicine, St John Regional Hospital, New Brunswick; Asso. Prof, Dalhousie University, Canada.

Joel Eissenberg

1982-1987 (NIH Fellowship); Professor of Biochemistry and Molecular Biology, Saint Louis University School of Medicine.

Sally Amero

1984-1987; Scientific Review Administrator, Genetic Sciences, NIH.

Graham H. Thomas

1984-1988; Associate Professor of Biology, Pennsylvania State University.

David Gilmour

1985-1989 (NIH Fellowship); Professor of Molecular and Cell Biology, Pennsylvania State University.

Angela van Daal

1986-1989; Professor and Asso. Dean, Research, Faculty of Health Sciences & Medicine, Bond University, Australia.

Quinn Lu

1988-1994; Senior Investigator, Department of Gene Expression and Protein Biochemistry, GlaxoSmithKline, King of Prussia PA

Robert Clark

1988-1992 (NIH Fellowship); Assistant Professor in Psychiatry, Meharry Medical College, Nashville, TN.

John Teare

1990-1993; Principal Scientist, Bayer Pharmaceuticals, Berkeley, CA.

Lori Wallrath

1991-1996 (NIH Fellowship); Professor, Department of Biochemistry, University of Iowa College of Medicine, IA

Boris A Leibovitch

1994-2004; Research Assistant Professor of Medicine, Mount Sinai School of Medicine, New York.

Marci Swede

1994-1996 (NIH Fellowship); Instructor, Biology, Middlesex Community College, Middletown, CT.

Gabrella Farkas

1996-2006; computer illustrator and data management specialist.

Fang-Lin Sun

1997-2001; Professor, School of Life Sciences & Technology, and Dean, Inst of Translational Medical Sciences, Tongji University, Shanghai, China.

Maria Kapatenaki

2001-2003; Research Associate at University of Pittsburgh.

Kathryn Huisinga

2005-2011; Asso Professor of Biology, Malone University, Canton OH.

Nicole Riddle

2005-2012; Asst Professor, Biology, University of Alabama, Birmingham AL.

Tingting Gu

2014; Asso Professor at Nanjing Agricultural Universiy, China

April Bauer

2013 – 2015; staff scientist, Sigma-Aldrich, St. Louis MO

Graduate students (current or last known position):

Lee M. Silver

Ph.D. in Biophysics, Harvard University, 1978; Professor of molecular biology and public policy in the Woodrow Wilson School of Public & International Affairs at Princeton University.

Carl E.C. Wu

Ph.D. in Biology, Harvard University, 1979; Laboratory Chief, Head Chromosome Structure & Gene Regulation Section, Lab. Biochem & Molec. Biol., NCI, NIH; currently Professor at Johns Hopkins University.

David W. Miller

Ph.D. in Biochemistry, Harvard University, 1980; Senior Director, Business Development, Synta Pharmaceuticals Corp, Lexington MA.

Yuk Chor Wong

M.A. in Biology, Harvard University, 1980.

Robert DeLorimier

Ph.D. in Biochemistry, Harvard University, 1982.

Michael A. Keene

Ph.D., in Biochemistry, Harvard University, 1983; former State Science Advisor and Director, Centers of Excellence Program, Utah; current Director, MBA-Technology Commercialization Program, Westminster College, Utah.

Esther Siegfriede

Ph.D. in Molecular Biology, Washington University, 1988; Asso Teaching Prof, Biology, University of Pennsylvania – Altoona.

Thomas Dietz

Ph.D. in Molecular Biology and Biochemistry, Washington University, 1990; Chairman & CEO at Waypoint Holdings, LLC, San Francisco.

Barbara Allen

M.A. in Biological Sciences, Washington University, 1991; consultant, writer and publisher on “Conquering Arthritis.”.

Cynthia Wagner

Ph.D. in Biological Sciences, Washington University, 1992; Senior Lecturer, Biological Sciences, University of Maryland – Baltimore County.

Howard Granok

Ph.D. in Biological Sciences, Washington University, 1996; biology teacher, Crossroads School, St. Louis, MO.

Gena Bloth Stephens

Ph.D. in Molecular Cell Biology, Washington University, 2005; Radiation Oncology, Licensing Associate, Washington University, St. Louis, MO.

Karmella Haynes

Graduate Student

Ph.D. in Molecular Genetics, Washington University, 2006; Associate Professor, Coulter Biomedical Engineering Dept, Georgia Tech / Emory University.

Brent Brower-Toland

Graduate Student

Ph.D. in Molecular Genetics, Washington University, 2008; currently a staff scientist with Monsanto.

Deanna Mendez

Graduate Student

Ph.D. in Molecular Biophysics, Washington University, 2012; postdoctoral research with Robert Kranz, Washington University in St Louis.

Monica Sentmanat

Graduate Student

Ph.D. in Molecular Genetics, Washington University, 2012; currently Senior Scientist, Tissue Culture Support Center, Washington University in St. Louis.

Sidney H Wang

Graduate Student

Ph.D. in Molecular Genetics, Washington University, 2012; Assistant Professor, Center for Human Genetics, McGovern Medical School, University of Texas, Houston, TX.

Kiri Ulmschneider

MA in Cell Biology, Washington University, 2017.

Former Lab Technicians

Carolyn Craig

Lab Technician

B.S. Biology, Harding University
Characterization of fourth chromosome inserts; distribution patterns of chromosomal proteins

Lynne Collins

Lab Technician

M.A. in Biology, Washington University; currently a research technician at Washington University Medical School

Sarah Gadel

Lab Technician

B.S. Biochemistry and Biotechnology (cum laude), University of Missouri-St. Louis.
Drosophila stock maintenance, population cage maintenance, and modENCODE Project.

Sarah Marchetti

Lab Technician

B.S. Biology, University of Missouri-St. Louis; M.S. Molecular Biology, St. Louis University.
modENCODE Project

Undergraduates in the Elgin lab  (>90 engaged in research)

Washington University 

Summer 2019:  Jennifer Ferry, Louis Gordon, Prasheil Mandava & Jared Moxley received BioSURF awards to participate in Drosophila genomics.

Lab assistance 18-19: Kevin Doan, Aidan Flynn, Isabelle Palmer Lillian Williams

Ariel Feng, Drosophila genomics summer 2018, continuing AY 18-19.

Amy Kwan, Drosophila genomics summer 2018, continuing AY 18-19.

Caelan Miller, Drosophila genomics summer 2018, continuing AY 18-19.

Muhammad Mousa, Drosophila genomics summer 2018

Alice Herrman, Drosophila genomics summer 2018, continuing AY 18-19.

Lab assistance 2017-18: Kevin Doan, Aidan Flynn, Isabelle Palmer.

Jon Zilke, Drosophila genomics summer 17, continuing on TSS AY 17-18.

Kendra Wooodruff, Drosophila genomics summer 17; research on repeats summer/fall 18, senior thesis 19.

Frank Chen, Drosophila genomics summer 17, AY 17-18.

Kelly Hartigan, Drosophila genomics summer 17; phage, fall 17.

Mitchell Grinwald, Drosophila genomics summer 17, summer 18.

Margaret Gaggioli, Drosophila genomics summer 17, fall 17.

Lab assistance, 16-17: Kevin Doan, Mikayla Johnson

Emily Chi, Drosophila genomics summer 2016; continued AY 16-17, senior thesis 2017.

Monica Perumattam, Drosophila genomics summer 2016.

Jacob Cantrell, Drosophila genomics summer 2016; fourth chromosome research, AY and summers 17, 18; BioSURF 2017; received WU support to attend Drosophila Research Conference, presented poster 18, 19; senior thesis 2019.

Guanlan Dong, Drosophila genomics summer 2016

Ben French. Drosophila genomics summers 16-18, AY; BioSURF 2017; received WU support to attend Drosophila Research Conference, presented poster 19; senior thesis 2019/

Mikayla Johnson, lab assistance fall 15 – spring 17; Drosophila genomics summer 2017, AY fall 17- spring 19.

Lab assistance 15-16: Mikayla Johnson, Casey Mason

Thomas Pranzatelli, reconciliation summer 2015 & senior thesis, sp 2016; grad school

Sarah Swiezy, work on finishing D. elegans, 4 wks summer 2015

Daniel Cui Zhou; reconciliation of gene models, part-time summer 2015

Sukruth Shashikumar, GAA-induced silencing 15-16; SURF summer 2016, senior thesis; med school WU

Lab assistance 14-15: Daniel Jung, Sukruth Shashikumar

Elizabeth Chen, Drosophila genomics, summer 2014; med school

Thomas Quisenberry, Drosophila genomics, summer 2014; senior thesis, sp 2015

Lab assistance fall 2013: Gary Huang, Jason Kunisaki

Michael Lee, lab asst 12-13; T Gu project fall 13; SURF with A Bauer summer 2014; SURF with E Gracheva, summer 2015 (NSF-REU); senior thesis sp 2016.

Sarah Doan, lab asst 12-13; genetics research 13-14

David Xiong, summer 2012, Bio 500 – Drosophila genomics

Paul Lee:  summer 2012 Drosophila genomics; capstone in Computer Science.

Lab assistance fall 11:  George Rizik, Nishanth Uli, Delia Shen

Kevin Ko, 11-12 – HP1a domains on polytenes; GEP, summer 2013; poster and senior thesis on D. ananassae.

George Rizik, summer 2011, Prefreshman (HP1a/polytenes/new species)

Rebecca Mandt, Grinnell College, summer 2011 (MedRap); HP1a studies w/ D Mendez

William Barshop, summer 2011; GEP; grad school UCLA.

Lab assistance 2010-2011: Viktor Panfil, Ran Annie Wang, Rita Chen, Kevin Ko

Han Yuan summer 2010   – annotation; summer 2011 SURF

Matt DeVries; summer 2010- population cages

Ruth Nan, 08 – 12; analysis of Y chromosome

Hien Nguyen, fall 09 maintenance; HP2 Y2H screen summer 10.

Jeannette Wong, summer 2009- May 11; annotation/genomics; MA Public Health

Anita Hoong, 08-09; screen for good “landing pad” sites

Hao Yang, 07-11; screen for good “landing pad” sites, characterization Invader4; SURF 2010, travel award (to Drosophila meeting); thesis/magna; med school Indiana

Patrick Ng, 09-12: screen for good “landing pad” sites; Y2H screen; SURF 2011; grad school Texas.

Micaela Blank, 08, 09, 10 summer: lab support, genetic test of RNAi lines, screen.

Michelle Wang, 07-08: lab support, genetic test of RNAi lines; genetic screen.

Lab assistance 2007-2008: Cara Kantor, Nikale Pettie, Jacob Vineberg, Sarah Rasmussen.

Greg Gandenberg, summer 07, 08, 09: lab support, genetic test of RNAi lines, screen.

Andrew Nylander, GEP

William Dirkes, 07-09; analysis of dot chromosomes (bioinformatics approach).  Senior thesis: Computational prediction of sequence-specific genomic elements influencing heterochromatin formation in D. melanogaster. Medical school.

Perry Morroco, 07-11; WU/HHMI Prefreshman Fellow; evolution of heterochromatin proteins; testing RNAi lines; Pc investigation WU/HHMI Fellowship 2010, travel award (Drosophila); thesis/summa; med school Northwestern.

Hongwei (David) Liu, 07-08, lab support, testing RNAi lines.

Elizabeth Messer, 07-09. Expression of fourth chromosome genes.  WU/HHMI Fellowship summer 08. Senior thesis: To what degree do P element reporters reflect the expression state of the genes near their insertion site?  Medical school.

Mathew Dorthager, 06-09.  Analysis of 1360 variegating lines; chromosome 4 genomics (GEP).  WU/HHMI Fellowship 08.  Technician Univ Texas Southwestern Medical School, Dallas, TX, then med school (Carribean)

Albert Wu, 06-08.  Lab support, screen and analysis of 1360 variegating lines.

Iboro Umana, 06-07; WU/HHMI Prefreshman Fellow; evolution of heterochromatin proteins.

Stephen McDaniel, 06-08; (WU/HHMI Fellowship ’07) role of 1360 in heterochromatin; tech then grad school UNC.

Shachar Shimonovich, 05-08; (WU/HHMI Fellowship ’07) screen to analyze 1360 role; tech, then med school Tel Aviv Sackler Am Prog.

Alejandra Figueroa-Clarevega, 05-07; role of 1360 in heterochromatin.  Tech at the Stowers Institute; planning grad school thereafter; Gilliam Fellowship, HHMI, 2008.  PhD student, UC Berkeley.

Wilson Leung, ’05-present; analysis of Drosophila dot chromosomes.

Michelle Itano, 05-06:  sequencing & analysis of D. virilis dot chromosome (WU/HHMI Fellow, ’05).  Ph.D. student, University of North Carolina.

Amy Wu, 04-07; screen to analyze 1360 role.  Attending law school 9/07.

Miriam Wiegand, 04-06:  heterochromatin elements on chromosome 4 (screen).

Kelli Grim, 04-06:  heterochromatin elements on chromosome 4 (screen); mutation in VIG2 (WU/HHMI Fellow, ’05).  MD student at Baylor.

Gladys Mensah, 03-06:  heterochromatin elements on chromosome 4 (screen, DNA analysis) (WU/HHMI Fellow, ’05).  Post-bac studies, University of Houston.

Kwame Adu-Wusu, 03-05:  Analysis of mutations in HP2 (WU/HHMI Fellow, ’04). MD student at Case-Western Reserve.

Laila Saied, 03-05:  Analysis of RNAi components affecting heterochromatin formation in tissue culture cells (Biomed Eng NIH fellowship, ’04).  MD student at Indiana (Internal Medicine).

Adrian Baudy, summer 03; participation in screen, 4th chromosome.

Alissa Anderson, 02- 03 :  Screen for GAGA factor-interacting loci (WU/HHMI Fellow, ’02). Lab Technician with Doug Chalker;  PhD program, Chicago

Rachel Shevchek, 02- 04:  Comparison of dot chromosome sequences (Biomed Eng NIH fellowship, ’02).  MD from Baylor.

Noelle Holmes, summer 02:  impact of HP2 mutations on chromosome morphology (WU/HHMI Prefreshman Fellow).

Laura Ruhl, 00 – 01:  HP2 of Drosophila virilis; current year in Africa, then to medical school.

Ann Beckert, summer 00, 01, 02: Screening for new insertions into chromosome 4; environmental sciences, Tulane. 

Elizabeth Slawson, 99 – 03:  Mutations in HP2; HP2 of Drosophila virilis (WU/HHMI Fellow                  ’02; travel award).  Technician and TA, Elgin lab, 03-05; PhD program at UC Berkeley.

Cory Simpson, 99 -03:  Organization of chromosome 4, mutations in HP2 (WU/HHMI Fellow    ’02; travel award; senior thesis, Spector Prize).  MD/PhD student, Northwestern University.

Brandi Thompson*, 98-02:  Mutations in HP2 (WU/HHMI Fellow ’00); PhD student, University of Michigan.

William Wooten, summer 99:  Interaction of HP1 and HP2 in Drosophila (WU/HHMI      Prefreshman Fellow).

Liza Colclazier, summers 98, 99:  Screening for new insertions into chromosome 4.

Shinkai Hakimi, spring 98:  Characterization of the trl gene in D. virilis.

John Bernat, 95-99:  Interactions of chromosomal proteins in gene silencing: towards a test of spatial organization in the Drosophila nucleus  (Stalker Prize, ’99; WU/HHMI Fellow ’98;      WU/HHMI Prefreshman Fellow, ’95);  MD/PhD, U Michigan.

Peter Weitzel, summers 96-99:  Mapping chromatin domains in the fourth chromosome of D.      melanogaster (WU/HHMI Fellow, ’99); high school teacher.

Dora Basu, summer 96:  Interactions between heterochromatin proteins (WU/HHMI Prefreshman Fellow).

Matt Cuaycong, 95-99 (BA/MA):  Chromatin structure of silenced genes (WU/HHMI Fellow,             ’96); MD program, UMDNJ- The New Jersey Medical School, Newark, NJ

Levi Funches*, 95-98:  HP1-HP2 interactions tested in yeast (NIH Minority Supplement, WU/HHMI Fellow ’97);  MD, Johns Hopkins; resident in pediatrics in Chicago.

Deepti Talwar, 94-95:  Yeast two-hybrid screen for proteins interacting with HP1;  Technician,   Baylor

Vamsi Guntur, 93-95:  Characterization of variegating transgenes in Drosophila; St. George’s    University School of Medicine

Jon Gibbons, summer 1993: Screen for variegating transgenic lines; MD from the Uniformed      Services University of the Health Sciences, 1999.

Mara Wilderspin, 92-94:  Mutations in HP1 (WU/HHMI Fellow, ’94).

Lisa Rosman, 92-94:  Characterization of variegating transgenes in Drosophila; MD from Rush   Medical College, Chicago, 2000.      

Andrea Holmes, 92-94:  GAGA factor binding and DNA bending (WU/HHMI Fellow, ’93);         Outreach Director, Human Genome Project, WU

Sandeep Pulim (91-95):  Characterization of the regulatory region of the hsp26  gene in D. virilis;  St. George’e University School of Medicine

Kevin Mitchell, summer 91:  Constructing mutations in hsp26;  PhD program, Biology, Stanford.

Otobia Dimson*, 90-92:  Distribution studies of HP1 (NSF REU; WU/HHMI Fellow); Medical   College of Wisconsin.

Benjamin Abella, 90-91:  Drosophila telomeres; MD, Johns Hopkins.

Tim Wescott, 89-91:  Purification of Drosophila H2AvD (NSF REU); PhD program, Chemistry, Rutgers.

Audrey Hobson, summer 88:  Distribution of HP1; PhD program, Genetics, Trinity, Dublin       

Scott Fretzin, 88- 89:  Cloning of the H3.3 gene of D. melanogaster;  MD program, U Chicago

Christina Lee, 85-86:  Investigations of Drosophila histone H1; PhD program, UCSF.

Santa Suryaraman, 84-86: Sites of topoisomerase II activity and matrix attachment at the 67B1 l  ocus of D. melanogaster. MD from UCSF.

Jorge Giraldo, 84-85.

Jacalyn Weissman, 84-85: S1 sensitive site in Drosophila locus 67B; entered medical school.

Fred Gross, 83-84: Bleomycin as a probe for DNA sequence organization and chromatin structure.

Harvard

Abram Gabriel, 76-77:  On the relationship between chromosomal proteins and gene expression.

Thomas Ashley, 75-76: The role of histones in transcription.

Caltech

Flora C. Wu, 72-73: Comparative studies of nonhistone chromosomal proteins; currently practicing MD.

James Garrels, 70-71:  A histone protease of rat liver chromatin; received PhD; Incyte Genomics.

Todd Reynales*, summer ’71:  Template activity of chromatin.

Robin Dore, summer ’70:  Chromatin fractionation.

Jeffrey Selzer, summer ’69: Nonhistone chromosomal proteins of chick liver and erythrocyte.

High school students and teachers (8)

Elmer Kellman, summer 2003, 2004:  cloning from the dot chromosome of Drosophila littoralis (teacher, Parkway)

Karman Mak, summer 95, AY 95-96:  analysis of chromosomal proteins on polytene chromosomes  (student, Parkway Central High School)

Todd Gienke, summer 95 (teacher, Whittfield High School)

Kathy Moreno, summer 94 (teacher, Wentzville High School)

Isey White*, AY 93-94 (student, Rosati Kain High School)

Tara Killebrew, summers 92, 93: distribution of HP1 in different Drosophila species (student, University City High School)

Michael Roberson*, summer (student, University City High School)

Mara Wilderspin, summer ’91 (student, University City High School)