Selected Recent Publications
Fong J, Gardner JG, Andrews JM, Cashen AF, Payton JE, Weinberger KQ, Edwards JR. Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM. Nucleic Acids Research. 2021 June 22; Sep 20;49(16):e93. doi: 10.1093/nar/gkab516. PMID: 34157105; PMCID: PMC8450090.
Boulard M*, Rucli S, Edwards JR*, Bestor TH*. Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14292-14298. doi: 10.1073/pnas.1912074117. Epub 2020 Jun 10. PubMed PMID: 32522876; PubMed Central PMCID: PMC7322000. * Co-corresponding authors.
Schlosberg CE, Wu DY, Gabel HW, Edwards JR. ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine. Nucleic Acids Res. 2019 Mar 18;47(5):e28. doi: 10.1093/nar/gkz001. PubMed PMID: 30649543; PubMed Central PMCID: PMC6412249.
Rajshekar S, Yao J, Arnold PK, Payne SG, Zhang Y, Bowman TV, Schmitz RJ, Edwards JR, Goll M. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Elife. 2018 Nov 28;7. doi: 10.7554/eLife.39658. PubMed PMID: 30484769; PubMed Central PMCID: PMC6261255.
Schlosberg CE, VanderKraats ND, Edwards JR. Modeling complex patterns of differential DNA methylation that associate with gene expression changes. Nucleic Acids Res. 2017 May 19;45(9):5100-5111. doi: 10.1093/nar/gkx078. PubMed PMID: 28168293; PubMed Central PMCID: PMC5435975.
Edwards JR, Yarychkivska O, Boulard M, Bestor TH. DNA methylation and DNA methyltransferases. Epigenetics Chromatin. 2017;10:23. doi: 10.1186/s13072-017-0130-8. eCollection 2017. Review. PubMed PMID: 28503201; PubMed Central PMCID: PMC5422929.
Hiken JF, McDonald JI, Decker KF, Sanchez C, Hoog J, VanderKraats ND, Jung KL, Akinhanmi M, Rois LE, Ellis MJ, Edwards JR. Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer. Oncogene. 2017 Apr 20;36(16):2319-2327. doi: 10.1038/onc.2016.397. Epub 2016 Nov 21. PubMed PMID: 27869171; PubMed Central PMCID: PMC5398938.
McDonald JI, Celik H, Rois LE, Fishberger G, Fowler T, Rees R, Kramer A, Martens A, Edwards JR, Challen GA. Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation. Biol Open. 2016 Jun 15;5(6):866-74. doi: 10.1242/bio.019067. PubMed PMID: 27170255; PubMed Central PMCID: PMC4920199.