Discovery of SARM1 Activation by Allosteric Metabolite Sensing Described in New Neuron Paper

SARM1 is the key executioner enzyme for axon degeneration. In a healthy neuron, SARM1 exists in an enzymatically “off” state. Axon injury turns on SARM1’s activity to hydrolyze the important metabolite NAD+, leading to metabolic crisis and axon fragmentation. The mechanism underlying SARM1 activation by axon injury was discovered in a recent study from the […]