Our program spans from bench to bedside across labs to clinical research team to 3D printing lab at WUSM. We have ongoing work in unraveling the mucosal immunology and microbiome in perianal Crohn’s disease. Additional projects are focused on image segmentation techniques for 3D volume rendered images and printed anatomical models funded by AGA Pilot and Mallinckrodt Institute of Radiology Pilot Awards Additional ongoing work with Dr. David Ballard funded by the Radiological Society of North America and the Litwin Grant from the Crohn’s and Colitis Foundation, focuses on exploring PET-MR as a novel tool for disease activity and response assessment in perianal fistulizing Crohn’s disease.
- Cao S, Deepak P, Colonna M. Pathogenesis of Perianal Fistulizing Crohn’s Disease: Current knowledge, gaps in understanding and future research direction. J Crohns Colitis. 2023 Jun 16;17(6):1010-1022. PMID: 36655753
- Ganapathy A, Navale P, Mutch MG, Kim H, Ballard DH, Deepak P. Long-Standing Symptomatic Fistulizing Perianal Crohn’s Disease: Progression Beyond Inflammation. Gastroenterology. 2023 Sep 12:S0016-5085(23)04997-1. PMID: 37709172
- McCurdy JD, Stwalley D, Olsen MA, Deepak P. Comparative Effectiveness of Biologic Therapies in Preventing Penetrating Complications in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2023 Sep 4:S1542-3565(23)00664-X. PMID: 37673348
- Huang K, Garuba F, Ganapathy A, Bishop G, Zhang H, Lovato A, Itani M, Viswanath SE, Fraum TJ, Deepak P, Ballard DH. Quantifying 18F-Fluorodeoxyglucose Uptake in Perianal Fistulas on PET/CT: A Retrospective Analysis. Academic Radiology 2024; [Ahead of print]. PubMed PMID: 38177032
- Cao S, Nguyen KM, Ma K, Yao X, Liu TC, Ayoub M, Devi J, Liu Y, Smith R, Silviera M, Hunt SR, Wise PE, Mutch MG, Glasgow SC, Chapman WC Jr, Cowan M, Ciorba MA, Colonna M, Deepak P. Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn’s Disease. bioRxiv [Preprint]. 2024 Nov 10:2024.11.08.620717. PMID: 39574705
- Kong, M.F., DeSilvio, T., Elumalai, A., George, A., Devi, J., Lovato, A., Ganapathy, A.K., Deepak, P.,Ballard, D.H. and Viswanath, S.E., 2024. Tu1994 AUTOMATED DEEP LEARNING SEGMENTATION OF ANAL SPHINCTER COMPLEX AND PERIANAL FISTULAS ON PELVIC MRI OF PERIANAL FISTULIZING CROHN’S DISEASE. Gastroenterology, 166(5), pp.S-1483.
- Schroeder MK, Abushamma S, George AT, Ravella B, Hickman J, Elumalai A, Wise P, Zulfiqar M, Ludwig DR, Shetty A, Viswanath SE, Luo C, Sebastian S, Ballard DH, Deepak P. TOpCLASS Expert Consensus Classification of Perianal Fistulising Crohn’s Disease: A Real-world Application in a Serial Fistula MRI Cohort. J Crohns Colitis. 2024 Sep 3;18(9):1430-1439. PMID: 38642332