Chemistry Core
Principal Investigator: Douglas Covey, PhD
The Chemistry Core synthesizes neurosteroid analogues to be used in all projects in the center.
Targets of Neurosteroid Anti-depressant Action
Principal Investigator: Alex Evers, MD
We aim to identify neurosteroid binding sites on target proteins to assess the functional role of these proteins in anti-depressant physiology and behavior.
Mechanistic Studes of Neurosteroid Analogues
Principal Investigator: Steven Mennerick, PhD
We seek to both understand mechanisms by which AlloP promotes therapeutic benefit and to improve on these benefits with neuroactive steroids that possess additional mechanisms.
Impact of Neuroactive Steroids on Network and Behavioral States
Principal Investigator: Jamie Maguire, PhD
Our project aims to investigate the mechanisms through which neuroactive steroids can influence network and behavioral states, providing insight into their antidepressant effects.