Welcome to the Colonna Lab

Microfold cells in the follicle-associated epithelium overlying a Peyer’s patch

The laboratory is broadly interested in innate immunity, focused on three main areas:
1) Innate lymphoid cells (ILCs) in mucosal immunity

2) Innate immune mechanisms in Alzheimer`s disease and neurodegeneration

3) Plasmacytoid dendritic cells and IFNα/β in host defense and autoimmunity

We are located in the BJC Institute of Health building at Washington University in St. Louis on the School of Medicine campus in the Central West End.

Current lab members

Group 3 innate lymphoid cells in a small intestine cryptopatch

Plaque-associated microglia in the 5xFAD mouse model. Stainings: Iba1 (microglia, green), Abeta1-42 (Abeta plaques, white), DAPI (nuclei, blue).