
Our Mission
- Decipher the genetic and epigenomic mechanisms regulating photoreceptor gene expression, development, and maintenance.
- Understand the pathogenesis underlying blinding disease linked to mutations in photoreceptor transcription factors, particularly the Cone-Rod-Homeobox protein CRX.
- Develop mechanism-based therapy strategies for treating CRX-associated photoreceptor disease.
- Training the next generation of vision scientists.
What We Do

Shiming Chen, PhD, Dr. Bernard and Janet R. Becker Distinguished Professor in Ophthalmology